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ECOLI:UVRC

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) uvrC
Protein Name(s) UvrABC system protein C

Protein UvrC Excinuclease ABC subunit C

External Links
UniProt P0A8G0
EMBL X03691
U00096
AP009048
M24615
X05398
M12299
PIR F64954
RefSeq NP_416423.4
YP_490170.1
PDB 1KFT
PDBsum 1KFT
ProteinModelPortal P0A8G0
SMR P0A8G0
DIP DIP-47875N
IntAct P0A8G0
MINT MINT-1221235
STRING 511145.b1913
PaxDb P0A8G0
PRIDE P0A8G0
EnsemblBacteria AAC74980
BAA15733
GeneID 12931385
947203
KEGG ecj:Y75_p1884
eco:b1913
PATRIC 32119159
EchoBASE EB1056
EcoGene EG11063
eggNOG COG0322
HOGENOM HOG000279961
InParanoid P0A8G0
KO K03703
OMA RCPGVCQ
OrthoDB EOG6K13R9
PhylomeDB P0A8G0
BioCyc EcoCyc:EG11063-MONOMER
ECOL316407:JW1898-MONOMER
MetaCyc:EG11063-MONOMER
EvolutionaryTrace P0A8G0
PRO PR:P0A8G0
Proteomes UP000000318
UP000000625
Genevestigator P0A8G0
GO GO:0005737
GO:0009380
GO:0003677
GO:0009381
GO:0006289
GO:0009432
Gene3D 3.40.1440.10
4.10.860.10
HAMAP MF_00203
InterPro IPR027299
IPR000305
IPR000445
IPR003583
IPR010994
IPR001943
IPR004791
IPR001162
Pfam PF01541
PF00633
PF02151
PF08459
SMART SM00465
SM00278
SUPFAM SSF46600
SSF47781
SSF82771
TIGRFAMs TIGR00194
PROSITE PS50164
PS50151
PS50165

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006289

nucleotide-excision repair

PMID:1387639[1]

ECO:0000315

P

Fig2, show mutations in His,Asp,Glu residues in catalytic domain affects ability to make a 5' incision

complete
CACAO 4590

part_of

GO:0009380

excinuclease repair complex

PMID:12145219[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009380

excinuclease repair complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11063
PANTHER:PTN000778007

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13993
PANTHER:PTN000778007

P

Seeded From UniProt

complete

involved_in

GO:0009314

response to radiation

PMID:27718375[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003583

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003583

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004791

P

Seeded From UniProt

complete

part_of

GO:0009380

excinuclease repair complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004791

C

Seeded From UniProt

complete

enables

GO:0009381

excinuclease ABC activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004791

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163512

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163512

C

Seeded From UniProt

complete

involved_in

GO:0009432

SOS response

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163512

P

Seeded From UniProt

complete

involved_in

GO:0006289

nucleotide-excision repair

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163512

P

Seeded From UniProt

complete

enables

GO:0009381

excinuclease ABC activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163512

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163512

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0228
UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

involved_in

GO:0009432

SOS response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0742

P

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0267

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lin, JJ & Sancar, A (1992) Active site of (A)BC excinuclease. I. Evidence for 5' incision by UvrC through a catalytic site involving Asp399, Asp438, Asp466, and His538 residues. J. Biol. Chem. 267 17688-92 PubMed GONUTS page
  2. Verhoeven, EE et al. (2002) The presence of two UvrB subunits in the UvrAB complex ensures damage detection in both DNA strands. EMBO J. 21 4196-205 PubMed GONUTS page
  3. 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Sargentini, NJ et al. () Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database. Mutat. Res. 793-794 1-14 PubMed GONUTS page