ECOLI:SECE

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	secE (ECO:0000255 with HAMAP-Rule:MF_00422) (synonyms: prlG)
Protein Name(s)	Protein translocase subunit SecE (ECO:0000255 with HAMAP-Rule:MF_00422)
External Links
UniProt	P0AG96
EMBL	M30610 U00006 U00096 AP009048
PIR	A35139
RefSeq	NP_418408.1 YP_491480.1
PDB	2AKH 2AKI 3J01 3J45 3J46
PDBsum	2AKH 2AKI 3J01 3J45 3J46
ProteinModelPortal	P0AG96
SMR	P0AG96
DIP	DIP-59303N
IntAct	P0AG96
STRING	511145.b3981
TCDB	3.A.5.1.1
PaxDb	P0AG96
PRIDE	P0AG96
EnsemblBacteria	AAC76955 BAE77339
GeneID	12930517 948486
KEGG	ecj:Y75_p3216 eco:b3981
PATRIC	32123483
EchoBASE	EB0932
EcoGene	EG10939
eggNOG	COG0690
HOGENOM	HOG000219148
InParanoid	P0AG96
KO	K03073
OMA	TRPEATQ
OrthoDB	EOG6DRPR4
BioCyc	EcoCyc:SECE ECOL316407:JW3944-MONOMER
EvolutionaryTrace	P0AG96
PRO	PR:P0AG96
Proteomes	UP000000318 UP000000625
Genevestigator	P0AG96
GO	GO:0031522 GO:0016021 GO:0005887 GO:0005622 GO:0005886 GO:0015450 GO:0065002 GO:0006886 GO:0009306 GO:0006605 GO:0043952
HAMAP	MF_00422
InterPro	IPR022943 IPR005807 IPR001901
Pfam	PF00584
PRINTS	PR01650
TIGRFAMs	TIGR00964
PROSITE	PS01067

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0065002	intracellular protein transmembrane transport	PMID:3284784^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043952	protein transport by the Sec complex	PMID:3284784^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:2673920^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:9180258^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	PMID:3284784^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:2673920^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0065002	intracellular protein transmembrane transport	PMID:7650029^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0065002	intracellular protein transmembrane transport	PMID:2167176^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0065002	intracellular protein transmembrane transport	PMID:1531482^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043952	protein transport by the Sec complex	PMID:7650029^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043952	protein transport by the Sec complex	PMID:2167176^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043952	protein transport by the Sec complex	PMID:1531482^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032978	protein insertion into membrane from inner side	PMID:9564033^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032978	protein insertion into membrane from inner side	PMID:10397756^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031522	cell envelope Sec protein transport complex	PMID:2167176^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031522	cell envelope Sec protein transport complex	PMID:1531482^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008320	protein transmembrane transporter activity	PMID:7650029^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006616	SRP-dependent cotranslational protein targeting to membrane, translocation	PMID:9564033^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006616	SRP-dependent cotranslational protein targeting to membrane, translocation	PMID:10397756^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2673920^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:2673920^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17309111^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15919996^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001901	P	Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001901	P	Seeded From UniProt	complete
involved_in	GO:0009306	protein secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005807	P	Seeded From UniProt	complete
enables	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005807	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001901	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005807	C	Seeded From UniProt	complete
enables	GO:0008565	obsolete protein transporter activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000368547	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000368547	C	Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000368547	P	Seeded From UniProt	complete
involved_in	GO:0009306	protein secretion	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000368547	P	Seeded From UniProt	complete
involved_in	GO:0043952	protein transport by the Sec complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000368547	P	Seeded From UniProt	complete
involved_in	GO:0065002	intracellular protein transmembrane transport	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000368547	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0997 UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0037	C	Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653 UniProtKB-KW:KW-0811	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Riggs, PD et al. (1988) A mutation affecting the regulation of a secA-lacZ fusion defines a new sec gene. Genetics 118 571-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Schatz, PJ et al. (1989) The secE gene encodes an integral membrane protein required for protein export in Escherichia coli. Genes Dev. 3 1035-44 PubMed GONUTS page
↑ Homma, T et al. (1997) Subunit interactions in the Escherichia coli protein translocase: SecE and SecG associate independently with SecY. FEBS Lett. 408 11-5 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Douville, K et al. (1995) SecYEG and SecA are the stoichiometric components of preprotein translocase. J. Biol. Chem. 270 20106-11 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Brundage, L et al. (1990) The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation. Cell 62 649-57 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Brundage, L et al. (1992) SecY, SecE, and band 1 form the membrane-embedded domain of Escherichia coli preprotein translocase. J. Biol. Chem. 267 4166-70 PubMed GONUTS page
↑ ^7.0 ^7.1 Valent, QA et al. (1998) The Escherichia coli SRP and SecB targeting pathways converge at the translocon. EMBO J. 17 2504-12 PubMed GONUTS page
↑ ^8.0 ^8.1 Koch, HG et al. (1999) In vitro studies with purified components reveal signal recognition particle (SRP) and SecA/SecB as constituents of two independent protein-targeting pathways of Escherichia coli. Mol. Biol. Cell 10 2163-73 PubMed GONUTS page
↑ Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

[PMID:3284784-1] 1.0 ^1.1 ^1.2 Riggs, PD et al. (1988) A mutation affecting the regulation of a secA-lacZ fusion defines a new sec gene. Genetics 118 571-9 PubMed GONUTS page

[PMID:2673920-2] 2.0 ^2.1 ^2.2 ^2.3 Schatz, PJ et al. (1989) The secE gene encodes an integral membrane protein required for protein export in Escherichia coli. Genes Dev. 3 1035-44 PubMed GONUTS page

[PMID:9180258-3] Homma, T et al. (1997) Subunit interactions in the Escherichia coli protein translocase: SecE and SecG associate independently with SecY. FEBS Lett. 408 11-5 PubMed GONUTS page

[PMID:7650029-4] 4.0 ^4.1 ^4.2 Douville, K et al. (1995) SecYEG and SecA are the stoichiometric components of preprotein translocase. J. Biol. Chem. 270 20106-11 PubMed GONUTS page

[PMID:2167176-5] 5.0 ^5.1 ^5.2 Brundage, L et al. (1990) The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation. Cell 62 649-57 PubMed GONUTS page

[PMID:1531482-6] 6.0 ^6.1 ^6.2 Brundage, L et al. (1992) SecY, SecE, and band 1 form the membrane-embedded domain of Escherichia coli preprotein translocase. J. Biol. Chem. 267 4166-70 PubMed GONUTS page

[PMID:9564033-7] 7.0 ^7.1 Valent, QA et al. (1998) The Escherichia coli SRP and SecB targeting pathways converge at the translocon. EMBO J. 17 2504-12 PubMed GONUTS page

[PMID:10397756-8] 8.0 ^8.1 Koch, HG et al. (1999) In vitro studies with purified components reveal signal recognition particle (SRP) and SecA/SecB as constituents of two independent protein-targeting pathways of Escherichia coli. Mol. Biol. Cell 10 2163-73 PubMed GONUTS page

[PMID:17309111-9] Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page

[PMID:15919996-10] Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

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ECOLI:SECE

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