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ECOLI:SECA

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) secA (synonyms: azi, pea, prlD)
Protein Name(s) Protein translocase subunit SecA
External Links
UniProt P10408
EMBL M20791
M19211
X55034
U00096
AP009048
PIR B64732
RefSeq NP_414640.1
YP_488403.1
PDB 1TM6
2FSF
2FSG
2FSH
2FSI
2VDA
3BXZ
PDBsum 1TM6
2FSF
2FSG
2FSH
2FSI
2VDA
3BXZ
ProteinModelPortal P10408
SMR P10408
BioGrid 849222
DIP DIP-10840N
IntAct P10408
MINT MINT-1224866
STRING 511145.b0098
TCDB 3.A.5.1.1
PaxDb P10408
PRIDE P10408
EnsemblBacteria AAC73209
BAB96666
GeneID 12932123
944821
KEGG ecj:Y75_p0097
eco:b0098
PATRIC 32115301
EchoBASE EB0929
EcoGene EG10936
eggNOG COG0653
HOGENOM HOG000218168
InParanoid P10408
KO K03070
OMA ERFFILQ
OrthoDB EOG654P48
PhylomeDB P10408
BioCyc EcoCyc:SECA
ECOL316407:JW0096-MONOMER
EvolutionaryTrace P10408
PRO PR:P10408
Proteomes UP000000318
UP000000625
Genevestigator P10408
GO GO:0031522
GO:0005737
GO:0005829
GO:0005887
GO:0005886
GO:0005524
GO:0042802
GO:0046872
GO:0015462
GO:0061077
GO:0065002
GO:0017038
GO:0006605
GO:0015031
GO:0043952
Gene3D 1.10.3060.10
3.40.50.300
3.90.1440.10
HAMAP MF_01382
InterPro IPR027417
IPR004027
IPR000185
IPR020937
IPR011115
IPR014018
IPR011130
IPR011116
Pfam PF02810
PF07517
PF01043
PF07516
PRINTS PR00906
SMART SM00957
SM00958
SUPFAM SSF52540
SSF81767
SSF81886
TIGRFAMs TIGR00963
PROSITE PS01312
PS51196

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043952

protein transport by the Sec complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10936
PANTHER:PTN000770133
UniProtKB:P9WGP3
UniProtKB:P9WGP5

P

Seeded From UniProt

complete

part_of

GO:0031522

cell envelope Sec protein transport complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10936
PANTHER:PTN000770133
UniProtKB:P9WGP5

C

Seeded From UniProt

complete

enables

GO:0015462

ATPase-coupled protein transmembrane transporter activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10936
PANTHER:PTN000770123

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10936
PANTHER:PTN000770133

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10936
PANTHER:PTN000770133
UniProtKB:P9WGP5

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000770123
UniProtKB:P9WGP5

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21037004[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10408

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18022369[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10408

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16079137[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10408

F

Seeded From UniProt

complete

involved_in

GO:0065002

intracellular protein transmembrane transport

PMID:6279567[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043952

protein transport by the Sec complex

PMID:6279567[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

PMID:6279567[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006605

protein targeting

PMID:6279567[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:1837021[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:1837021[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061077

chaperone-mediated protein folding

PMID:14597695[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043952

protein transport by the Sec complex

PMID:2167176[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031522

cell envelope Sec protein transport complex

PMID:2167176[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031522

cell envelope Sec protein transport complex

PMID:2139227[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0015462

ATPase-coupled protein transmembrane transporter activity

PMID:2542029[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:7968527[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:1837021[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:7968527[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:1837021[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000185
InterPro:IPR011115

F

Seeded From UniProt

complete

involved_in

GO:0006605

protein targeting

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000185
InterPro:IPR020937

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000185
InterPro:IPR020937

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011115
InterPro:IPR011116
InterPro:IPR011130
InterPro:IPR020937
InterPro:IPR036670

C

Seeded From UniProt

complete

involved_in

GO:0017038

protein import

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011115
InterPro:IPR011116
InterPro:IPR011130
InterPro:IPR036670

P

Seeded From UniProt

complete

involved_in

GO:0006605

protein targeting

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000076237

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000076237

F

Seeded From UniProt

complete

involved_in

GO:0065002

intracellular protein transmembrane transport

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000076237

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000076237

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0997
UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0037

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0811
UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Suo, Y et al. (2011) Orientation of SecA and SecB in complex, derived from disulfide cross-linking. J. Bacteriol. 193 190-6 PubMed GONUTS page
  3. ↑ Gelis, I et al. (2007) Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR. Cell 131 756-69 PubMed GONUTS page
  4. ↑ Stenberg, F et al. (2005) Protein complexes of the Escherichia coli cell envelope. J. Biol. Chem. 280 34409-19 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Oliver, DB & Beckwith, J (1982) Identification of a new gene (secA) and gene product involved in the secretion of envelope proteins in Escherichia coli. J. Bacteriol. 150 686-91 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Cabelli, RJ et al. (1991) Characterization of membrane-associated and soluble states of SecA protein from wild-type and SecA51(TS) mutant strains of Escherichia coli. J. Biol. Chem. 266 24420-7 PubMed GONUTS page
  7. ↑ Eser, M & Ehrmann, M (2003) SecA-dependent quality control of intracellular protein localization. Proc. Natl. Acad. Sci. U.S.A. 100 13231-4 PubMed GONUTS page
  8. ↑ 8.0 8.1 Brundage, L et al. (1990) The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation. Cell 62 649-57 PubMed GONUTS page
  9. ↑ Driessen, AJ & Wickner, W (1990) Solubilization and functional reconstitution of the protein-translocation enzymes of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 87 3107-11 PubMed GONUTS page
  10. ↑ Lill, R et al. (1989) SecA protein hydrolyzes ATP and is an essential component of the protein translocation ATPase of Escherichia coli. EMBO J. 8 961-6 PubMed GONUTS page
  11. ↑ 11.0 11.1 Mitchell, C & Oliver, D (1993) Two distinct ATP-binding domains are needed to promote protein export by Escherichia coli SecA ATPase. Mol. Microbiol. 10 483-97 PubMed GONUTS page
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