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ECOLI:RUVC

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) ruvC
Protein Name(s) Crossover junction endodeoxyribonuclease RuvC

Holliday junction nuclease RuvC Holliday junction resolvase RuvC

External Links
UniProt P0A814
EMBL X59551
D10165
U00096
AP009048
PIR D38113
RefSeq NP_416377.1
YP_490125.1
PDB 1HJR
PDBsum 1HJR
ProteinModelPortal P0A814
SMR P0A814
DIP DIP-35952N
IntAct P0A814
STRING 511145.b1863
PaxDb P0A814
PRIDE P0A814
EnsemblBacteria AAC74933
BAA15674
GeneID 12934241
946378
KEGG ecj:Y75_p1839
eco:b1863
PATRIC 32119049
EchoBASE EB0918
EcoGene EG10925
eggNOG COG0817
HOGENOM HOG000012181
InParanoid P0A814
KO K01159
OMA YTALQMK
OrthoDB EOG6RG044
PhylomeDB P0A814
BioCyc EcoCyc:EG10925-MONOMER
ECOL316407:JW1852-MONOMER
MetaCyc:EG10925-MONOMER
EvolutionaryTrace P0A814
PRO PR:P0A814
Proteomes UP000000318
UP000000625
Genevestigator P0A814
GO GO:0005737
GO:0048476
GO:0008821
GO:0000287
GO:0003676
GO:0000737
GO:0000725
GO:0071932
Gene3D 3.30.420.10
HAMAP MF_00034
InterPro IPR012337
IPR020563
IPR002176
Pfam PF02075
PRINTS PR00696
SUPFAM SSF53098
TIGRFAMs TIGR00228
PROSITE PS01321

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0048476

Holliday junction resolvase complex

PMID:16895921[1]

ECO:0000315

C

Figure 4. "Following UV irradiation, ruvC mutants exhibited a loss of genomic integrity...Holliday structures and higher order intermediates persisted on the plasmids following replication."

complete
CACAO 3815

involved_in

GO:0071932

replication fork reversal

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10925
PANTHER:PTN001249669

P

Seeded From UniProt

complete

part_of

GO:0048476

Holliday junction resolvase complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10925
PANTHER:PTN001249669

C

Seeded From UniProt

complete

enables

GO:0008821

crossover junction endodeoxyribonuclease activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10925
PANTHER:PTN001249669

F

Seeded From UniProt

complete

involved_in

GO:0000725

recombinational repair

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10925
PANTHER:PTN001249669

P

Seeded From UniProt

complete

part_of

GO:0048476

Holliday junction resolvase complex

PMID:9160752[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009314

response to radiation

PMID:27718375[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008821

crossover junction endodeoxyribonuclease activity

PMID:1829835[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008821

crossover junction endodeoxyribonuclease activity

PMID:1661673[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000725

recombinational repair

PMID:6374379[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR036397

F

Seeded From UniProt

complete

enables

GO:0004520

endodeoxyribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002176

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002176

P

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002176

P

Seeded From UniProt

complete

enables

GO:0008821

crossover junction endodeoxyribonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020563

F

Seeded From UniProt

complete

enables

GO:0008821

crossover junction endodeoxyribonuclease activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.22.4

F

Seeded From UniProt

complete

enables

GO:0008821

crossover junction endodeoxyribonuclease activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163880

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163880

P

Seeded From UniProt

complete

enables

GO:0000287

magnesium ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163880

F

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000163880

P

Seeded From UniProt

complete

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

involved_in

GO:0006310

DNA recombination

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0233

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Donaldson, JR et al. (2006) RuvABC is required to resolve holliday junctions that accumulate following replication on damaged templates in Escherichia coli. J. Biol. Chem. 281 28811-21 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Eggleston, AK et al. (1997) In vitro reconstitution of the late steps of genetic recombination in E. coli. Cell 89 607-17 PubMed GONUTS page
  4. ↑ Sargentini, NJ et al. () Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database. Mutat. Res. 793-794 1-14 PubMed GONUTS page
  5. ↑ Connolly, B et al. (1991) Resolution of Holliday junctions in vitro requires the Escherichia coli ruvC gene product. Proc. Natl. Acad. Sci. U.S.A. 88 6063-7 PubMed GONUTS page
  6. ↑ Iwasaki, H et al. (1991) Escherichia coli RuvC protein is an endonuclease that resolves the Holliday structure. EMBO J. 10 4381-9 PubMed GONUTS page
  7. ↑ Lloyd, RG et al. (1984) Effect of ruv mutations on recombination and DNA repair in Escherichia coli K12. Mol. Gen. Genet. 194 303-9 PubMed GONUTS page
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