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PMID:6374379

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Citation

Lloyd, RG, Benson, FE and Shurvinton, CE (1984) Effect of ruv mutations on recombination and DNA repair in Escherichia coli K12. Mol. Gen. Genet. 194:303-9

Abstract

Mutation of the ruv gene of E. coli is associated with sensitivity to radiation, and filamentous growth after transient inhibition of DNA synthesis. The filamentation of ruv strains is abolished by mutations in sfiA or sfiB that prevent SOS induced inhibition of cell division, but this does not restore resistance to UV radiation. Double mutants carrying both ruv and uvr mutations are considerably more sensitive to UV radiation than the single mutants, but there is no additive effect of ruv with recA, recF, recB, or recC mutations. ruv mutations have little effect on conjugal recombination in wild-type strains but confer recombination deficiency and extreme sensitivity to ionizing radiation in recBC sbcB strains. These results, together with the fact that ruv strains are excision proficient and mutable by UV light, are interpreted to suggest that the ruv + product is involved in recombinational repair of damaged DNA rather than in cell division as suggested by Otsuji et al. (1974).

Links

PubMed

Keywords

Bacterial Proteins/metabolism; DNA Ligases/metabolism; DNA Repair; DNA, Bacterial/metabolism; DNA, Bacterial/radiation effects; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Regulation; Genes, Bacterial; Recombination, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:RUVA

acts_upstream_of_or_within

GO:0000725: recombinational repair

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:RUVB

acts_upstream_of_or_within

GO:0000725: recombinational repair

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:RUVC

acts_upstream_of_or_within

GO:0000725: recombinational repair

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:RUVC

involved_in

GO:0000725: recombinational repair

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:RUVB

involved_in

GO:0000725: recombinational repair

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ECOLI:RUVA

involved_in

GO:0000725: recombinational repair

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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