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ECOLI:PRPC

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) prpC (synonyms: yahS, yzzD)
Protein Name(s) 2-methylcitrate synthase

Citrate synthase 2 Methylcitrate synthase

External Links
UniProt P31660
EMBL U73857
U00096
AP009048
PIR E64760
RefSeq NP_414867.1
YP_488627.1
ProteinModelPortal P31660
SMR P31660
DIP DIP-10579N
IntAct P31660
STRING 511145.b0333
EnsemblBacteria AAC73436
BAE76115
GeneID 12930815
947528
KEGG ecj:Y75_p0322
eco:b0333
PATRIC 32115797
EchoBASE EB1706
EcoGene EG11756
eggNOG COG0372
HOGENOM HOG000021225
InParanoid P31660
KO K01659
OMA IKGWSKK
OrthoDB EOG6P8TP4
PhylomeDB P31660
BioCyc EcoCyc:G6198-MONOMER
ECOL316407:JW0324-MONOMER
MetaCyc:G6198-MONOMER
BRENDA 2.3.3.5
UniPathway UPA00946
PRO PR:P31660
Proteomes UP000000318
UP000000625
Genevestigator P31660
GO GO:0005737
GO:0050440
GO:0004108
GO:0044262
GO:0019679
GO:0006099
Gene3D 1.10.230.10
1.10.580.10
InterPro IPR011278
IPR016142
IPR016143
IPR002020
IPR016141
IPR019810
IPR024176
PANTHER PTHR11739
Pfam PF00285
PIRSF PIRSF001369
PRINTS PR00143
SUPFAM SSF48256
TIGRFAMs TIGR01800
PROSITE PS00480

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050440

2-methylcitrate synthase activity

PMID:9579066[1]

ECO:0000314

F

Table 1 shows a significant increase in 2-methylcitrate synthase activity when the carbon source in the growth medium was propionate.

complete
CACAO 4449

involved_in

GO:0019679

propionate metabolic process, methylcitrate cycle

PMID:9579066[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

PMID:9325432[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050440

2-methylcitrate synthase activity

PMID:9579066[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050440

2-methylcitrate synthase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11756
PANTHER:PTN002621568
UniProtKB:Q56063
UniProtKB:Q8EJW2

F

Seeded From UniProt

complete

involved_in

GO:0019679

propionate metabolic process, methylcitrate cycle

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11756
PANTHER:PTN002621568
UniProtKB:Q56063

P

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201223
PomBase:SPAC6C3.04
RGD:620330
SGD:S000006205
UniProtKB:Q9I5E3

P

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000201223
UniProtKB:O75390

P

Seeded From UniProt

complete

part_of

GO:0005759

mitochondrial matrix

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88529
PANTHER:PTN000201222
UniProtKB:O75390

C

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11756
FB:FBgn0261955
PANTHER:PTN000201223
PomBase:SPAC6C3.04
RGD:620330
SGD:S000000598
SGD:S000005284
SGD:S000006205
TAIR:locus:2050554
TAIR:locus:2052379
TAIR:locus:2098989
UniProtKB:O00098
UniProtKB:O75390
UniProtKB:Q9TEM3
dictyBase:DDB_G0267426

F

Seeded From UniProt

complete

enables

GO:0050440

2-methylcitrate synthase activity

PMID:9325432[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019679

propionate metabolic process, methylcitrate cycle

PMID:9325432[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050440

2-methylcitrate synthase activity

PMID:9325432[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

PMID:25564669[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P0ABH7

F

Seeded From UniProt

complete

enables

GO:0004108

citrate (Si)-synthase activity

PMID:9579066[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011278

C

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019810

P

Seeded From UniProt

complete

enables

GO:0046912

transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002020
InterPro:IPR011278
InterPro:IPR019810
InterPro:IPR036969

F

Seeded From UniProt

complete

enables

GO:0050440

2-methylcitrate synthase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.3.5

F

Seeded From UniProt

complete

involved_in

GO:0006099

tricarboxylic acid cycle

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0816
UniPathway:UPA00223

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Gerike, U et al. (1998) Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships. Microbiology (Reading, Engl.) 144 ( Pt 4) 929-35 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Textor, S et al. (1997) Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria. Arch. Microbiol. 168 428-36 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Guzmán, GI et al. (2015) Model-driven discovery of underground metabolic functions in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 112 929-34 PubMed GONUTS page
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