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ECOLI:PRC

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) prc (synonyms: tsp)
Protein Name(s) Tail-specific protease

C-terminal-processing peptidase PRC protein Protease Re

External Links
UniProt P23865
EMBL D00674
D00674
M75634
U00096
AP009048
S49803
L48409
PIR A41798
RefSeq NP_416344.1
YP_490092.1
ProteinModelPortal P23865
SMR P23865
DIP DIP-10557N
IntAct P23865
MINT MINT-1283244
STRING 511145.b1830
MEROPS S41.001
PaxDb P23865
PRIDE P23865
EnsemblBacteria AAC74900
BAA15638
GeneID 12934469
946096
KEGG ecj:Y75_p1806
eco:b1830
PATRIC 32118981
EchoBASE EB0753
EcoGene EG10760
eggNOG COG0793
HOGENOM HOG000277886
InParanoid P23865
KO K03797
OMA AFAHEID
OrthoDB EOG6D5FZF
PhylomeDB P23865
BioCyc EcoCyc:EG10760-MONOMER
ECOL316407:JW1819-MONOMER
MetaCyc:EG10760-MONOMER
RETL1328306-WGS:GSTH-5958-MONOMER
PRO PR:P23865
Proteomes UP000000318
UP000000625
Genevestigator P23865
GO GO:0030288
GO:0005886
GO:0004175
GO:0008236
GO:0030163
GO:0006508
GO:0042493
Gene3D 2.30.42.10
3.90.226.10
InterPro IPR029045
IPR001478
IPR004447
IPR005151
IPR020992
Pfam PF11818
PF00595
PF03572
SMART SM00228
SM00245
SUPFAM SSF50156
SSF52096
TIGRFAMs TIGR00225
PROSITE PS50106

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0030288

outer membrane-bounded periplasmic space

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10760
PANTHER:PTN001279639

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001279639
UniProtKB:O35002
UniProtKB:Q9HU50
UniProtKB:Q9HYY3

P

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10760
PANTHER:PTN000786001

F

Seeded From UniProt

complete

involved_in

GO:0030163

protein catabolic process

PMID:8520476[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:8520476[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:8520476[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

PMID:1447154[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030288

outer membrane-bounded periplasmic space

PMID:1856173[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:25426869[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004447
InterPro:IPR005151

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004447
InterPro:IPR005151

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0997
UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0037

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 Keiler, KC et al. (1995) C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease. Protein Sci. 4 1507-15 PubMed GONUTS page
  3. Seoane, A et al. (1992) Multiple antibiotic susceptibility associated with inactivation of the prc gene. J. Bacteriol. 174 7844-7 PubMed GONUTS page
  4. Hara, H et al. (1991) Cloning, mapping, and characterization of the Escherichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3. J. Bacteriol. 173 4799-813 PubMed GONUTS page
  5. Lykkemark, S et al. (2014) Degradation of C-terminal tag sequences on domain antibodies purified from E. coli supernatant. MAbs 6 1551-9 PubMed GONUTS page