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ECOLI:PARC
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | parC (ECO:0000255 with HAMAP-Rule:MF_00936) | |
| Protein Name(s) | DNA topoisomerase 4 subunit A (ECO:0000255 with HAMAP-Rule:MF_00936)
Topoisomerase IV subunit A (ECO:0000255 with HAMAP-Rule:MF_00936) | |
| External Links | ||
| UniProt | P0AFI2 | |
| EMBL | M58408 M63491 U28377 U00096 AP009048 L22025 | |
| PIR | A65089 | |
| RefSeq | NP_417491.1 YP_491211.1 | |
| PDB | 1ZVT 1ZVU 4MN4 | |
| PDBsum | 1ZVT 1ZVU 4MN4 | |
| ProteinModelPortal | P0AFI2 | |
| SMR | P0AFI2 | |
| DIP | DIP-36030N | |
| IntAct | P0AFI2 | |
| MINT | MINT-1227290 | |
| STRING | 511145.b3019 | |
| BindingDB | P0AFI2 | |
| ChEMBL | CHEMBL2363076 | |
| DrugBank | DB00817 | |
| PaxDb | P0AFI2 | |
| PRIDE | P0AFI2 | |
| EnsemblBacteria | AAC76055 BAE77075 | |
| GeneID | 12933371 947499 | |
| KEGG | ecj:Y75_p2945 eco:b3019 | |
| PATRIC | 32121452 | |
| EchoBASE | EB0680 | |
| EcoGene | EG10686 | |
| eggNOG | COG0188 | |
| HOGENOM | HOG000076277 | |
| InParanoid | P0AFI2 | |
| KO | K02621 | |
| OMA | YILETRL | |
| OrthoDB | EOG661H5V | |
| PhylomeDB | P0AFI2 | |
| BioCyc | EcoCyc:EG10686-MONOMER ECOL316407:JW2987-MONOMER | |
| EvolutionaryTrace | P0AFI2 | |
| PRO | PR:P0AFI2 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P0AFI2 | |
| GO | GO:0005694 GO:0005737 GO:0009330 GO:0019897 GO:0009295 GO:0005524 GO:0003677 GO:0003918 GO:0006200 GO:0007059 GO:0006265 GO:0006268 GO:0030541 GO:0007062 | |
| Gene3D | 3.30.1360.40 3.90.199.10 | |
| HAMAP | MF_00936 | |
| InterPro | IPR024946 IPR006691 IPR002205 IPR013758 IPR013760 IPR005742 | |
| Pfam | PF03989 PF00521 | |
| SMART | SM00434 | |
| SUPFAM | SSF56719 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0003918 |
DNA topoisomerase (ATP-hydrolyzing) activity |
ECO:0000314 |
F |
Topoisomerase assay in Fig 3. ATP dependent decatenation means it is a Type II from Fig 4 |
complete | |||||
|
part_of |
GO:0009330 |
DNA topoisomerase complex (ATP-hydrolyzing) |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10686 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10686 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10423 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10423 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001607041 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0003918 |
DNA topoisomerase type II (ATP-hydrolyzing) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10423 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10423 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030541 |
plasmid partitioning |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019897 |
extrinsic component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009330 |
DNA topoisomerase complex (ATP-hydrolyzing) |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007062 |
sister chromatid cohesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002205 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003918 |
DNA topoisomerase type II (ATP-hydrolyzing) activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002205 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002205 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006259 |
DNA metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR002205 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0019897 |
extrinsic component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000165615 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006265 |
DNA topological change |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000165615 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000165615 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003918 |
DNA topoisomerase type II (ATP-hydrolyzing) activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000165615 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000165615 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003916 |
DNA topoisomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Peng, H & Marians, KJ (1993) Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions. J. Biol. Chem. 268 24481-90 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Peng, H & Marians, KJ (1993) Decatenation activity of topoisomerase IV during oriC and pBR322 DNA replication in vitro. Proc. Natl. Acad. Sci. U.S.A. 90 8571-5 PubMed GONUTS page
- ↑ 4.0 4.1 Kato, J et al. (1992) Purification and characterization of DNA topoisomerase IV in Escherichia coli. J. Biol. Chem. 267 25676-84 PubMed GONUTS page
- ↑ Wang, X et al. (2008) Modulation of Escherichia coli sister chromosome cohesion by topoisomerase IV. Genes Dev. 22 2426-33 PubMed GONUTS page
- ↑ Kato, J et al. (1988) Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli. J. Bacteriol. 170 3967-77 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Corbett, KD et al. (2005) The structural basis for substrate specificity in DNA topoisomerase IV. J. Mol. Biol. 351 545-61 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
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c
d
- GO:0003677 ! DNA binding
- GO:0006259 ! DNA metabolic process
- GO:0009330 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
- GO:0003916 ! DNA topoisomerase activity
- GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
- GO:0006265 ! DNA topological change
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