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ECOLI:MLTA

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) mltA (synonyms: mlt, ygdM)
Protein Name(s) Membrane-bound lytic murein transglycosylase A

Mlt38 Murein hydrolase A

External Links
UniProt P0A935
EMBL U32224
U29581
U00096
AP009048
PIR A65064
RefSeq NP_417293.1
WP_000678646.1
PDB 2AE0
2GAE
2PI8
2PIC
2PJJ
PDBsum 2AE0
2GAE
2PI8
2PIC
2PJJ
ProteinModelPortal P0A935
SMR P0A935
BioGrid 4261126
DIP DIP-51238N
IntAct P0A935
STRING 511145.b2813
CAZy GH102
PaxDb P0A935
PRIDE P0A935
EnsemblBacteria AAC75855
BAE76885
GeneID 944964
KEGG ecj:JW2784
eco:b2813
PATRIC 32121044
EchoBASE EB2894
EcoGene EG13085
eggNOG ENOG4105CA3
COG2821
HOGENOM HOG000278098
InParanoid P0A935
KO K08304
OMA KREDMSM
OrthoDB EOG6D2KR5
PhylomeDB P0A935
BioCyc EcoCyc:G7457-MONOMER
ECOL316407:JW2784-MONOMER
MetaCyc:G7457-MONOMER
EvolutionaryTrace P0A935
PRO PR:P0A935
Proteomes UP000000318
UP000000625
GO GO:0009279
GO:0005829
GO:0016021
GO:0005887
GO:0016837
GO:0004553
GO:0008933
GO:0071555
GO:0009252
GO:0009254
Gene3D 2.40.40.10
InterPro IPR010611
IPR005300
IPR009009
Pfam PF06725
PF03562
SMART SM00925
SUPFAM SSF50685
PROSITE PS51257

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009279

cell outer membrane

PMID:9287002[1]

ECO:0000314

C

Figure 4 Membrane fractionation by sucrose gradient centrifugation shows that the MltA protein is also localized in the outer membrane

complete
CACAO 12190

enables

GO:0008933

lytic transglycosylase activity

PMID:8288527[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8288527[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

PMID:9287002[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009253

peptidoglycan catabolic process

PMID:8288527[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009253

peptidoglycan catabolic process

PMID:23421439[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008933

lytic transglycosylase activity

PMID:8288527[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008933

lytic transglycosylase activity

PMID:23421439[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

PMID:8288527[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004553

hydrolase activity, hydrolyzing O-glycosyl compounds

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005300
InterPro:IPR010611

F

Seeded From UniProt

complete

involved_in

GO:0009254

peptidoglycan turnover

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010611

P

Seeded From UniProt

complete

part_of

GO:0019867

outer membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010611

C

Seeded From UniProt

complete

part_of

GO:0030288

outer membrane-bounded periplasmic space

PMID:15174130[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0998
UniProtKB-SubCell:SL-0040

C

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0071555

cell wall organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0961

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Lommatzsch, J et al. (1997) Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli. J. Bacteriol. 179 5465-70 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Ursinus, A & Höltje, JV (1994) Purification and properties of a membrane-bound lytic transglycosylase from Escherichia coli. J. Bacteriol. 176 338-43 PubMed GONUTS page
  3. 3.0 3.1 Lee, M et al. (2013) Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. J. Am. Chem. Soc. 135 3311-4 PubMed GONUTS page
  4. Gonnet, P et al. (2004) Fine-tuning the prediction of sequences cleaved by signal peptidase II: a curated set of proven and predicted lipoproteins of Escherichia coli K-12. Proteomics 4 1597-613 PubMed GONUTS page