ECOLI:MCP1

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	tsr (synonyms: cheD)
Protein Name(s)	Methyl-accepting chemotaxis protein I MCP-I Serine chemoreceptor protein
External Links
UniProt	P02942
EMBL	V00373 U14003 U00096 AP009048 S56952
PIR	E65250
RefSeq	NP_418775.1 YP_492486.1
PDB	1QU7 2D4U 3ATP 3ZX6
PDBsum	1QU7 2D4U 3ATP 3ZX6
DisProt	DP00300
ProteinModelPortal	P02942
SMR	P02942
DIP	DIP-11046N
IntAct	P02942
MINT	MINT-1306492
STRING	511145.b4355
PaxDb	P02942
PRIDE	P02942
EnsemblBacteria	AAC77311 BAE78345
GeneID	12932750 948884
KEGG	ecj:Y75_p4240 eco:b4355
PATRIC	32124316
EchoBASE	EB1027
EcoGene	EG11034
eggNOG	COG0840
HOGENOM	HOG000148074
InParanoid	P02942
KO	K05874
OMA	NALKHDK
OrthoDB	EOG6G4VQG
PhylomeDB	P02942
BioCyc	EcoCyc:TSR-MONOMER ECOL316407:JW4318-MONOMER
EvolutionaryTrace	P02942
PRO	PR:P02942
Proteomes	UP000000318 UP000000625
Genevestigator	P02942
GO	GO:0005887 GO:0043424 GO:0004888 GO:0048870 GO:0006935 GO:0043200 GO:0007165
Gene3D	1.20.120.30
InterPro	IPR004090 IPR003122 IPR004091 IPR003660 IPR004089
Pfam	PF00672 PF00015 PF02203
PRINTS	PR00260
SMART	SM00304 SM00283 SM00319
SUPFAM	SSF47170
PROSITE	PS00538 PS50111 PS50885

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005886	plasma membrane	PMID:334749^[1]	ECO:0000314			C	table 4 and fig 2,3,4	complete
	GO:0008984	protein-glutamate methylesterase activity	PMID:21803986^[2]	ECO:0000315			F	Fig 1 shows methylation sites indicating glutamine residues that must be deamidated to glutamates	complete CACAO 5043
	GO:0007165	signal transduction	PMID:21803986^[2]	ECO:0000315			P	Fig. 4 shows examples of tsr control cable mutants signaling defects. See also Fig 7.	complete CACAO 5840
	GO:0006935	chemotaxis	PMID:21803986^[2]	ECO:0000315			P	Figure 2: shows mutant chemotaxis phenotypes	complete CACAO 5841
	GO:0060286	flagellar cell motility	PMID:21803986^[2]	ECO:0000315			P	Figure 3	complete CACAO 5842
	GO:0048870	cell motility	PMID:21803986^[2]	ECO:0000315			P	Figure 2 and 5 show motility through chemotaxis	complete CACAO 5906
involved_in	GO:0071230	cellular response to amino acid stimulus	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032110	regulation of protein histidine kinase activity	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043113	receptor clustering	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007172	signal complex assembly	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050920	regulation of chemotaxis	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009593	detection of chemical stimulus	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0098561	methyl accepting chemotaxis protein complex	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1902021	regulation of bacterial-type flagellum-dependent cell motility	PMID:18931127^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	PMID:21803986^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21803986^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:21803986^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10987 EcoGene:EG10988 EcoGene:EG11018 EcoGene:EG11034 PANTHER:PTN002079588	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10988 EcoGene:EG11018 EcoGene:EG11034 PANTHER:PTN002460933	C	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10987 EcoGene:EG10988 EcoGene:EG11018 EcoGene:EG11034 PANTHER:PTN002460933	F	Seeded From UniProt	complete
enables	GO:0043424	protein histidine kinase binding	PMID:1326408^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	PMID:3029028^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:333433^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:333434^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:334749^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:6402709^[9]	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17309111^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15919996^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15911532^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:333433^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004090	F	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003122 InterPro:IPR004090	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003122 InterPro:IPR003660 InterPro:IPR004089 InterPro:IPR004090	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004089 InterPro:IPR004090	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003660	C	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0997 UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0037	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ridgway, HG et al. (1977) Localization of proteins controlling motility and chemotaxis in Escherichia coli. J. Bacteriol. 132 657-65 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Kitanovic, S et al. (2011) Mutational analysis of the control cable that mediates transmembrane signaling in the Escherichia coli serine chemoreceptor. J. Bacteriol. 193 5062-72 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Mowery, P et al. (2008) Different signaling roles of two conserved residues in the cytoplasmic hairpin tip of Tsr, the Escherichia coli serine chemoreceptor. J. Bacteriol. 190 8065-74 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Gegner, JA et al. (1992) Assembly of an MCP receptor, CheW, and kinase CheA complex in the bacterial chemotaxis signal transduction pathway. Cell 70 975-82 PubMed GONUTS page
↑ Callahan, AM et al. (1987) Chemotaxis in Escherichia coli: construction and properties of lambda tsr transducing phage. J. Bacteriol. 169 1246-53 PubMed GONUTS page
↑ ^7.0 ^7.1 Springer, MS et al. (1977) Sensory transduction in Escherichia coli: two complementary pathways of information processing that involve methylated proteins. Proc. Natl. Acad. Sci. U.S.A. 74 3312-6 PubMed GONUTS page
↑ Silverman, M & Simon, M (1977) Chemotaxis in Escherichia coli: methylation of che gene products. Proc. Natl. Acad. Sci. U.S.A. 74 3317-21 PubMed GONUTS page
↑ Boyd, A et al. () Structure of the serine chemoreceptor in Escherichia coli. Nature 301 623-6 PubMed GONUTS page
↑ Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page
↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page

[PMID:334749-1] 1.0 ^1.1 Ridgway, HG et al. (1977) Localization of proteins controlling motility and chemotaxis in Escherichia coli. J. Bacteriol. 132 657-65 PubMed GONUTS page

[PMID:21803986-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Kitanovic, S et al. (2011) Mutational analysis of the control cable that mediates transmembrane signaling in the Escherichia coli serine chemoreceptor. J. Bacteriol. 193 5062-72 PubMed GONUTS page

[PMID:18931127-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 Mowery, P et al. (2008) Different signaling roles of two conserved residues in the cytoplasmic hairpin tip of Tsr, the Escherichia coli serine chemoreceptor. J. Bacteriol. 190 8065-74 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1326408-5] Gegner, JA et al. (1992) Assembly of an MCP receptor, CheW, and kinase CheA complex in the bacterial chemotaxis signal transduction pathway. Cell 70 975-82 PubMed GONUTS page

[PMID:3029028-6] Callahan, AM et al. (1987) Chemotaxis in Escherichia coli: construction and properties of lambda tsr transducing phage. J. Bacteriol. 169 1246-53 PubMed GONUTS page

[PMID:333433-7] 7.0 ^7.1 Springer, MS et al. (1977) Sensory transduction in Escherichia coli: two complementary pathways of information processing that involve methylated proteins. Proc. Natl. Acad. Sci. U.S.A. 74 3312-6 PubMed GONUTS page

[PMID:333434-8] Silverman, M & Simon, M (1977) Chemotaxis in Escherichia coli: methylation of che gene products. Proc. Natl. Acad. Sci. U.S.A. 74 3317-21 PubMed GONUTS page

[PMID:6402709-9] Boyd, A et al. () Structure of the serine chemoreceptor in Escherichia coli. Nature 301 623-6 PubMed GONUTS page

[PMID:17309111-10] Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page

[PMID:15919996-11] Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

[PMID:15911532-12] Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

ECOLI:MCP1

Contents

Annotations

Notes

References

b

c

d

e

g

i

m

o

p

r

s

t

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools