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ECOLI:MAO1

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) maeA (synonyms: sfcA)
Protein Name(s) NAD-dependent malic enzyme

NAD-ME

External Links
UniProt P26616
EMBL U00096
AP009048
X55956
PIR B64901
RefSeq NP_415996.2
YP_489744.1
ProteinModelPortal P26616
SMR P26616
IntAct P26616
STRING 511145.b1479
PaxDb P26616
PRIDE P26616
EnsemblBacteria AAC74552
BAA15127
GeneID 12931214
946031
KEGG ecj:Y75_p1455
eco:b1479
PATRIC 32118252
EchoBASE EB0941
EcoGene EG10948
eggNOG COG0281
HOGENOM HOG000042487
InParanoid P26616
KO K00027
OMA IQDNNET
OrthoDB EOG6QVRGM
PhylomeDB P26616
BioCyc EcoCyc:MALIC-NAD-MONOMER
ECOL316407:JW5238-MONOMER
MetaCyc:MALIC-NAD-MONOMER
SABIO-RK P26616
PRO PR:P26616
Proteomes UP000000318
UP000000625
Genevestigator P26616
GO GO:0004471
GO:0046872
GO:0051287
GO:0008948
GO:0006094
GO:0006108
Gene3D 3.40.50.10380
3.40.50.720
HAMAP MF_01619
InterPro IPR015884
IPR012301
IPR012302
IPR001891
IPR016040
IPR023667
Pfam PF00390
PF03949
PIRSF PIRSF000106
PRINTS PR00072
SMART SM00919
PROSITE PS00331

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006108

malate metabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002719
PANTHER:PTN000601050
PomBase:SPCC794.12c
TAIR:locus:2017854
TAIR:locus:2052045
TAIR:locus:2054085
TAIR:locus:2127038
TAIR:locus:2180547
TAIR:locus:2181980
UniProtKB:P48163
UniProtKB:Q16798

P

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000601050
PomBase:SPCC794.12c
SGD:S000001512
UniProtKB:Q16798

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10948
PANTHER:PTN002361249
UniProtKB:P9WK25

C

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000601050
RGD:3074
SGD:S000001512
UniProtKB:P23368
UniProtKB:P48163
UniProtKB:Q16798

F

Seeded From UniProt

complete

involved_in

GO:0006094

gluconeogenesis

PMID:11815613[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004471

malate dehydrogenase (decarboxylating) (NAD+) activity

PMID:9212416[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001891

F

Seeded From UniProt

complete

enables

GO:0004471

malate dehydrogenase (decarboxylating) (NAD+) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001891
InterPro:IPR012301
InterPro:IPR015884
InterPro:IPR023667
InterPro:IPR037062

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012302

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012301
InterPro:IPR015884
InterPro:IPR023667
InterPro:IPR037062

P

Seeded From UniProt

complete

enables

GO:0004471

malate dehydrogenase (decarboxylating) (NAD+) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.38

F

Seeded From UniProt

complete

enables

GO:0008948

oxaloacetate decarboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.38

F

Seeded From UniProt

complete

enables

GO:0004471

malate dehydrogenase (decarboxylating) (NAD+) activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000080051

F

Seeded From UniProt

complete

enables

GO:0008948

oxaloacetate decarboxylase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000080051

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Oh, MK et al. (2002) Global expression profiling of acetate-grown Escherichia coli. J. Biol. Chem. 277 13175-83 PubMed GONUTS page
  3. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  4. Stols, L & Donnelly, MI (1997) Production of succinic acid through overexpression of NAD(+)-dependent malic enzyme in an Escherichia coli mutant. Appl. Environ. Microbiol. 63 2695-701 PubMed GONUTS page