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ECOLI:LUXS
Contents
| Species (Taxon ID) | Escherichia coli (strain K12). (83333) | |
| Gene Name(s) | luxS (synonyms: ygaG) | |
| Protein Name(s) | S-ribosylhomocysteine lyase
AI-2 synthesis protein Autoinducer-2 production protein LuxS | |
| External Links | ||
| UniProt | P45578 | |
| EMBL | U00096 AP009048 U83186 M86657 | |
| PIR | H65048 | |
| RefSeq | NP_417172.1 YP_490901.1 | |
| ProteinModelPortal | P45578 | |
| SMR | P45578 | |
| DIP | DIP-10131N | |
| IntAct | P45578 | |
| STRING | 511145.b2687 | |
| BindingDB | P45578 | |
| ChEMBL | CHEMBL3496 | |
| SWISS-2DPAGE | P45578 | |
| PaxDb | P45578 | |
| PRIDE | P45578 | |
| EnsemblBacteria | AAC75734 BAA16549 | |
| GeneID | 12934186 947168 | |
| KEGG | ecj:Y75_p2630 eco:b2687 | |
| PATRIC | 32120768 | |
| EchoBASE | EB2573 | |
| EcoGene | EG12712 | |
| eggNOG | COG1854 | |
| HOGENOM | HOG000040371 | |
| InParanoid | P45578 | |
| KO | K07173 | |
| OMA | KQPNQDH | |
| OrthoDB | EOG68WRBM | |
| PhylomeDB | P45578 | |
| BioCyc | EcoCyc:EG12712-MONOMER ECOL316407:JW2662-MONOMER MetaCyc:EG12712-MONOMER | |
| BRENDA | 4.4.1.21 | |
| SABIO-RK | P45578 | |
| PRO | PR:P45578 | |
| Proteomes | UP000000318 UP000000625 | |
| Genevestigator | P45578 | |
| GO | GO:0005506 GO:0043768 GO:0010699 GO:0019284 | |
| Gene3D | 3.30.1360.80 | |
| HAMAP | MF_00091 | |
| InterPro | IPR011249 IPR003815 | |
| Pfam | PF02664 | |
| PIRSF | PIRSF006160 | |
| PRINTS | PR01487 | |
| ProDom | PD013172 | |
| SUPFAM | SSF63411 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0071977 |
bacterial-type flagellum-dependent swimming motility |
ECO:0000315 |
P |
Figure 1- E. coli LuxS mutant strain shows increased swimming motility compared to WT E. coli strain in motility buffer. Figure 3- E.coli LuxS mutant strain shows complete formation of functional flagella whereas WT e. coli do not in motility buffer. |
complete | |||||
|
enables |
GO:0043768 |
S-ribosylhomocysteine lyase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043768 |
S-ribosylhomocysteine lyase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019284 |
L-methionine salvage from S-adenosylmethionine |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010699 |
cell-cell signaling involved in quorum sensing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009372 |
quorum sensing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043768 |
S-ribosylhomocysteine lyase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043768 |
S-ribosylhomocysteine lyase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009372 |
quorum sensing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000076351 |
P |
Seeded From UniProt |
complete | ||
| GO:0043768 |
S-ribosylhomocysteine lyase activity |
ECO:0000314 |
F |
LuxS does not act in the SAM catabolism pathway (figure:2B) |
complete | |||||
|
enables |
GO:0043768 |
S-ribosylhomocysteine lyase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000076351 |
F |
Seeded From UniProt |
complete | ||
| GO:0009372 |
quorum sensing |
ECO:0000315 |
P |
Autoinducer-production phenotypes of V. harveyi and S. typhimurium strains. Cell-free culture fluids from V. harveyi and S. typhimurium strains were prepared and tested for AI-2 activity in the V. harveyi BB170 bioassay. (A) AI-2 production phenotypes of the wild-type V. harveyi strain MM28, which contains a Tn5 insertion outside of luxSV.h. (denoted WT) and the luxSV.h.∷Tn5 mutant strain MM30 (denoted luxS−). (B) AI-2-production phenotypes of wild-type S. typhimurium LT2 (denoted WT) and the ygaG∷MudJ insertion mutant strain CS132 (denoted ygaG−). Activity is reported as fold-induction of luminescence expression of the V. harveyi BB170 reporter strain over that when sterile medium was added. |
complete | |||||
|
enables |
GO:0016829 |
lyase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009372 |
quorum sensing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ling, H et al. (2010) The absence of the luxS gene increases swimming motility and flagella synthesis in Escherichia coli K12. Biochem. Biophys. Res. Commun. 401 521-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Schauder, S et al. (2001) The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol. Microbiol. 41 463-76 PubMed GONUTS page
- ↑ 3.0 3.1 Surette, MG et al. (1999) Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proc. Natl. Acad. Sci. U.S.A. 96 1639-44 PubMed GONUTS page
- ↑ DeLisa, MP et al. (2001) DNA microarray-based identification of genes controlled by autoinducer 2-stimulated quorum sensing in Escherichia coli. J. Bacteriol. 183 5239-47 PubMed GONUTS page
- ↑ Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
- ↑ Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page
