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ECOLI:LOLC

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) lolC (synonyms: ycfU)
Protein Name(s) Lipoprotein-releasing system transmembrane protein LolC
External Links
UniProt P0ADC3
EMBL U00096
AP009048
PIR A64856
RefSeq NP_415634.1
YP_489384.1
ProteinModelPortal P0ADC3
DIP DIP-58651N
STRING 511145.b1116
TCDB 3.A.1.125.1
PaxDb P0ADC3
PRIDE P0ADC3
EnsemblBacteria AAC74200
BAA35936
GeneID 12932917
945673
KEGG ecj:Y75_p1086
eco:b1116
PATRIC 32117479
EchoBASE EB3213
EcoGene EG13439
eggNOG COG4591
HOGENOM HOG000218040
InParanoid P0ADC3
KO K09808
OMA YVKHVTF
OrthoDB EOG68SVTW
PhylomeDB P0ADC3
BioCyc EcoCyc:YCFU-MONOMER
ECOL316407:JW5161-MONOMER
PRO PR:P0ADC3
Proteomes UP000000318
UP000000625
Genevestigator P0ADC3
GO GO:0005887
GO:0043234
GO:0042954
GO:0042953
InterPro IPR003838
IPR011925
IPR025857
Pfam PF02687
PF12704
TIGRFAMs TIGR02212

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0089705

protein localization to outer membrane

PMID:12823819[1]

ECO:0000315

P

Figure 6, panel B. Mutant LolC(A40P)DE results in AcrA (an inner membrane protein) being localized to the outer membrane.

complete
CACAO 10141

involved_in

GO:0089705

protein localization to outer membrane

PMID:12823819[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:10783239[2]

ECO:0000314

C

Fig2C

complete
CACAO 10458

part_of

GO:0098797

plasma membrane protein complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13439
EcoGene:EG13441
PANTHER:PTN002524722

C

Seeded From UniProt

complete

involved_in

GO:0044874

lipoprotein localization to outer membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13439
EcoGene:EG13441
PANTHER:PTN002524722
UniProtKB:Q9HZL6
UniProtKB:Q9HZL8

P

Seeded From UniProt

complete

involved_in

GO:0042953

lipoprotein transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002524722
UniProtKB:Q9HZL8

P

Seeded From UniProt

complete

part_of

GO:0098797

plasma membrane protein complex

PMID:10783239[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0044874

lipoprotein localization to outer membrane

PMID:11844772[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044874

lipoprotein localization to outer membrane

PMID:10783239[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:17309111[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:15919996[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003838

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011925

C

Seeded From UniProt

complete

involved_in

GO:0042953

lipoprotein transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011925

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0997
UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0037

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Narita, S et al. (2003) A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals. Mol. Microbiol. 49 167-77 PubMed GONUTS page
  2. 2.0 2.1 2.2 Yakushi, T et al. (2000) A new ABC transporter mediating the detachment of lipid-modified proteins from membranes. Nat. Cell Biol. 2 212-8 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Narita, S et al. (2002) Disruption of lolCDE, encoding an ATP-binding cassette transporter, is lethal for Escherichia coli and prevents release of lipoproteins from the inner membrane. J. Bacteriol. 184 1417-22 PubMed GONUTS page
  5. Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
  6. Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page