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ECOLI:HLDD

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) hldD (synonyms: htrM, rfaD, waaD)
Protein Name(s) ADP-L-glycero-D-manno-heptose-6-epimerase

ADP-L-glycero-beta-D-manno-heptose-6-epimerase ADP-glyceromanno-heptose 6-epimerase ADP-hep 6-epimerase AGME

External Links
UniProt P67910
EMBL M33577
X54492
U00039
U00096
AP009048
PIR JU0299
RefSeq NP_418076.1
YP_491814.1
PDB 1EQ2
2X6T
PDBsum 1EQ2
2X6T
ProteinModelPortal P67910
SMR P67910
DIP DIP-35958N
IntAct P67910
STRING 511145.b3619
SWISS-2DPAGE P67910
PaxDb P67910
PRIDE P67910
EnsemblBacteria AAC76643
BAE77673
GeneID 12934299
948134
KEGG ecj:Y75_p3555
eco:b3619
PATRIC 32122725
EchoBASE EB0831
EcoGene EG10838
eggNOG COG0451
HOGENOM HOG000167987
InParanoid P67910
KO K03274
OMA YIPFPEK
OrthoDB EOG6384GP
PhylomeDB P67910
BioCyc EcoCyc:EG10838-MONOMER
ECOL316407:JW3594-MONOMER
MetaCyc:EG10838-MONOMER
SABIO-RK P67910
UniPathway UPA00356
UPA00958
EvolutionaryTrace P67910
PRO PR:P67910
Proteomes UP000000318
UP000000625
Genevestigator P67910
GO GO:0005829
GO:0016020
GO:0008712
GO:0070401
GO:0097171
GO:0009244
Gene3D 3.40.50.720
HAMAP MF_01601
InterPro IPR001509
IPR011912
IPR016040
PANTHER PTHR10366:SF29
Pfam PF01370
TIGRFAMs TIGR02197

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0016020

membrane

PMID:16858726[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16858726[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0070401

NADP+ binding

PMID:11313358[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009244

lipopolysaccharide core region biosynthetic process

PMID:383699[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008712

ADP-glyceromanno-heptose 6-epimerase activity

PMID:7929099[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15911532[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001509

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011912

P

Seeded From UniProt

complete

enables

GO:0008712

ADP-glyceromanno-heptose 6-epimerase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011912

F

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011912

F

Seeded From UniProt

complete

enables

GO:0050662

coenzyme binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001509

F

Seeded From UniProt

complete

enables

GO:0008712

ADP-glyceromanno-heptose 6-epimerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.1.3.20

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000079203

P

Seeded From UniProt

complete

enables

GO:0008712

ADP-glyceromanno-heptose 6-epimerase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000079203

F

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0119

P

Seeded From UniProt

complete

involved_in

GO:0009103

lipopolysaccharide biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0448

P

Seeded From UniProt

complete

involved_in

GO:0097171

ADP-L-glycero-beta-D-manno-heptose biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00356

P

Seeded From UniProt

complete

involved_in

GO:0009244

lipopolysaccharide core region biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00958

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed GONUTS page
  2. Ni, Y et al. (2001) Evidence that NADP+ is the physiological cofactor of ADP-L-glycero-D-mannoheptose 6-epimerase. J. Biol. Chem. 276 27329-34 PubMed GONUTS page
  3. Coleman, WG Jr & Leive, L (1979) Two mutations which affect the barrier function of the Escherichia coli K-12 outer membrane. J. Bacteriol. 139 899-910 PubMed GONUTS page
  4. Ding, L et al. (1994) Purification and properties of the Escherichia coli K-12 NAD-dependent nucleotide diphosphosugar epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase. J. Biol. Chem. 269 24384-90 PubMed GONUTS page
  5. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  6. Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page