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ECOLI:HFQ

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) hfq (ECO:0000255 with HAMAP-Rule:MF_00436)
Protein Name(s) RNA-binding protein Hfq (ECO:0000255 with HAMAP-Rule:MF_00436)

HF-1 Host factor-I protein HF-I

External Links
UniProt P0A6X3
EMBL D00743
U14003
U00096
AP009048
M63655
U00005
PIR S26832
RefSeq NP_418593.1
YP_492314.1
PDB 1HK9
1M7C
1OOU
1OOV
2Y90
2YHT
3GIB
3QHS
3QO3
3RER
3RES
3VU3
4JRI
4JRK
4JUV
PDBsum 1HK9
1M7C
1OOU
1OOV
2Y90
2YHT
3GIB
3QHS
3QO3
3RER
3RES
3VU3
4JRI
4JRK
4JUV
ProteinModelPortal P0A6X3
SMR P0A6X3
DIP DIP-36047N
IntAct P0A6X3
MINT MINT-8200668
STRING 511145.b4172
PaxDb P0A6X3
PRIDE P0A6X3
EnsemblBacteria AAC77129
BAE78173
GeneID 12932256
948689
KEGG ecj:Y75_p4058
eco:b4172
PATRIC 32123917
EchoBASE EB0433
EcoGene EG10438
eggNOG COG1923
HOGENOM HOG000004931
InParanoid P0A6X3
KO K03666
OMA RRDGHAQ
OrthoDB EOG68SW3W
PhylomeDB P0A6X3
BioCyc EcoCyc:EG10438-MONOMER
ECOL316407:JW4130-MONOMER
EvolutionaryTrace P0A6X3
PRO PR:P0A6X3
Proteomes UP000000318
UP000000625
Genevestigator P0A6X3
GO GO:0003681
GO:0003723
GO:0040033
GO:0045975
GO:0006355
HAMAP MF_00436
InterPro IPR005001
IPR010920
IPR001163
Pfam PF01423
SUPFAM SSF50182
TIGRFAMs TIGR02383

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0061157

mRNA destabilization

PMID:16352828[1]

ECO:0000314

P

Fig 5.Hfq specifically binds to traJ 5' UTR.

complete

GO:0010529

negative regulation of transposition

PMID:20815820[2]

ECO:0000315

P

tables 1 and 2

complete

involved_in

GO:0045974

regulation of translation, ncRNA-mediated

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002164223
UniProtKB:Q9HUM0

P

Seeded From UniProt

complete

involved_in

GO:0043487

regulation of RNA stability

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002164223
UniProtKB:Q9HUM0

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10438
PANTHER:PTN002164223

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10438
PANTHER:PTN002164223

F

Seeded From UniProt

complete

involved_in

GO:0040033

negative regulation of translation, ncRNA-mediated

PMID:19118351[4]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003681

bent DNA binding

PMID:10551881[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045975

positive regulation of translation, ncRNA-mediated

PMID:8654929[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:9774349[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005001

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005001

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000030788

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Will, WR & Frost, LS (2006) Hfq is a regulator of F-plasmid TraJ and TraM synthesis in Escherichia coli. J. Bacteriol. 188 124-31 PubMed GONUTS page
  2. Ross, JA et al. (2010) Tn10/IS10 transposition is downregulated at the level of transposase expression by the RNA-binding protein Hfq. Mol. Microbiol. 78 607-21 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. Pulvermacher, SC et al. (2009) Role of the sRNA GcvB in regulation of cycA in Escherichia coli. Microbiology (Reading, Engl.) 155 106-14 PubMed GONUTS page
  5. Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed GONUTS page
  6. Muffler, A et al. (1996) The RNA-binding protein HF-I, known as a host factor for phage Qbeta RNA replication, is essential for rpoS translation in Escherichia coli. Genes Dev. 10 1143-51 PubMed GONUTS page
  7. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  8. Zhang, A et al. (1998) The OxyS regulatory RNA represses rpoS translation and binds the Hfq (HF-I) protein. EMBO J. 17 6061-8 PubMed GONUTS page