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ECOLI:FUR

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) fur
Protein Name(s) Ferric uptake regulation protein

Ferric uptake regulator

External Links
UniProt P0A9A9
EMBL X02589
U00096
AP009048
PIR S07308
RefSeq NP_415209.1
YP_488963.1
PDB 2FU4
PDBsum 2FU4
ProteinModelPortal P0A9A9
SMR P0A9A9
BioGrid 849672
DIP DIP-31858N
IntAct P0A9A9
MINT MINT-1312814
STRING 511145.b0683
SWISS-2DPAGE P0A9A9
PaxDb P0A9A9
PRIDE P0A9A9
EnsemblBacteria AAC73777
BAA35331
GeneID 12933116
945295
KEGG ecj:Y75_p0662
eco:b0683
PATRIC 32116559
EchoBASE EB0354
EcoGene EG10359
eggNOG COG0735
HOGENOM HOG000014144
InParanoid P0A9A9
KO K03711
OMA DERSDIG
OrthoDB EOG6J48SS
PhylomeDB P0A9A9
BioCyc EcoCyc:PD00260
ECOL316407:JW0669-MONOMER
EvolutionaryTrace P0A9A9
PRO PR:P0A9A9
Proteomes UP000000318
UP000000625
Genevestigator P0A9A9
GO GO:0005737
GO:0003677
GO:0003700
GO:0008270
GO:0006351
Gene3D 1.10.10.10
InterPro IPR002481
IPR011991
Pfam PF01475

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:20015147[1]

ECO:0001204

in vitro transcription assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:20015147[1]

ECO:0000279

western blot evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:11466300[2]

ECO:0005657

primer extension assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:10833520[3]

ECO:0005643

hydroxyl-radical footprinting evidence used in manual assertion

RefSeq:NC_000913.2

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:8107138[4]

ECO:0005633

ferric uptake regulator titration assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:10833520[3]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.2

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:8806672[5]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:17921503[6]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:11466300[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:10833520[3]

ECO:0005643

hydroxyl-radical footprinting evidence used in manual assertion

RefSeq:NC_000913.2

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:8107138[4]

ECO:0005633

ferric uptake regulator titration assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:2644221[7]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.2

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:20015147[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.3

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:11466300[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_011333.1

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:10833520[3]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.2

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:8806672[5]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:2644221[7]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:20015147[1]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:17921503[6]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032993

protein-DNA complex

PMID:11466300[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:11466300[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:2644221[7]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.2

F

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:11466300[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_011333.1

F

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:2644221[7]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:11466300[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:20015147[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.3

F

Seeded From UniProt

complete

enables

GO:0001216

DNA-binding transcription activator activity

PMID:20015147[1]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:11466300[2]

ECO:0005667

site-directed mutagenesis phenotypic evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:2644221[7]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.2

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:20015147[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.3

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:11466300[2]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_011333.1

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:2644221[7]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:20015147[1]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:11466300[2]

ECO:0001807

electrophoretic mobility shift assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1900705

negative regulation of siderophore biosynthetic process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002112483
UniProtKB:Q03456

P

Seeded From UniProt

complete

involved_in

GO:1900376

regulation of secondary metabolite biosynthetic process

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002112386
UniProtKB:Q9HT74

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10359
PANTHER:PTN002112386
UniProtKB:P0A0S8
UniProtKB:P0C6C8
UniProtKB:P54479
UniProtKB:P54574
UniProtKB:P74739
UniProtKB:P9WN85
UniProtKB:Q03456
UniProtKB:Q7BR72
UniProtKB:Q7CQY3
UniProtKB:Q8EFN3
UniProtKB:Q8PAL3
UniProtKB:Q8Y5U9
UniProtKB:Q9HT74
UniProtKB:Q9L2H5

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002112386
UniProtKB:Q03456

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10359
PANTHER:PTN002112386
UniProtKB:P9WN85

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10359
PANTHER:PTN002112441

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002112386
UniProtKB:P9WN87

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002112386
UniProtKB:Q9HT74

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:11985624[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15911532[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002481

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002481

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Nandal, A et al. (2010) Induction of the ferritin gene (ftnA) of Escherichia coli by Fe(2+)-Fur is mediated by reversal of H-NS silencing and is RyhB independent. Mol. Microbiol. 75 637-57 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Delany, I et al. (2001) Iron-dependent transcription of the frpB gene of Helicobacter pylori is controlled by the Fur repressor protein. J. Bacteriol. 183 4932-7 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Escolar, L et al. (2000) Evidence of an unusually long operator for the fur repressor in the aerobactin promoter of Escherichia coli. J. Biol. Chem. 275 24709-14 PubMed GONUTS page
  4. 4.0 4.1 Stojiljkovic, I et al. (1994) Fur regulon in gram-negative bacteria. Identification and characterization of new iron-regulated Escherichia coli genes by a fur titration assay. J. Mol. Biol. 236 531-45 PubMed GONUTS page
  5. 5.0 5.1 Polack, B et al. (1996) The Pseudomonas aeruginosa fumc and soda genes belong to an iron-responsive operon. Biochem. Biophys. Res. Commun. 226 555-60 PubMed GONUTS page
  6. 6.0 6.1 Chen, Z et al. (2007) Discovery of Fur binding site clusters in Escherichia coli by information theory models. Nucleic Acids Res. 35 6762-77 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Griggs, DW & Konisky, J (1989) Mechanism for iron-regulated transcription of the Escherichia coli cir gene: metal-dependent binding of fur protein to the promoters. J. Bacteriol. 171 1048-54 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. Katayama, A et al. (2002) Systematic search for zinc-binding proteins in Escherichia coli. Eur. J. Biochem. 269 2403-13 PubMed GONUTS page
  10. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  11. Lopez-Campistrous, A et al. (2005) Localization, annotation, and comparison of the Escherichia coli K-12 proteome under two states of growth. Mol. Cell Proteomics 4 1205-9 PubMed GONUTS page