ECOLI:FADR

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	fadR (ECO:0000255 with HAMAP-Rule:MF_00696) (synonyms: oleR, thdB)
Protein Name(s)	Fatty acid metabolism regulator protein (ECO:0000255 with HAMAP-Rule:MF_00696)
External Links
UniProt	P0A8V6
EMBL	X08087 U00096 AP009048
PIR	H64864
RefSeq	NP_415705.1 YP_489454.1
PDB	1E2X 1H9G 1H9T 1HW1 1HW2
PDBsum	1E2X 1H9G 1H9T 1HW1 1HW2
ProteinModelPortal	P0A8V6
SMR	P0A8V6
DIP	DIP-9564N
IntAct	P0A8V6
MINT	MINT-1264978
STRING	511145.b1187
PaxDb	P0A8V6
PRIDE	P0A8V6
EnsemblBacteria	AAC74271 BAA36042
GeneID	12931108 948652
KEGG	ecj:Y75_p1159 eco:b1187
PATRIC	32117620
EchoBASE	EB0277
EcoGene	EG10281
eggNOG	COG2186
HOGENOM	HOG000278467
InParanoid	P0A8V6
KO	K03603
OMA	INNFWET
OrthoDB	EOG6D8B86
PhylomeDB	P0A8V6
BioCyc	EcoCyc:PD01520 ECOL316407:JW1176-MONOMER
EvolutionaryTrace	P0A8V6
PRO	PR:P0A8V6
Proteomes	UP000000318 UP000000625
Genevestigator	P0A8V6
GO	GO:0005737 GO:0003677 GO:0000062 GO:0003700 GO:0019395 GO:0045892 GO:0045723 GO:0045893 GO:0019217 GO:0006351
Gene3D	1.10.10.10 1.20.120.530
HAMAP	MF_00696
InterPro	IPR014178 IPR028374 IPR008920 IPR000524 IPR011991
Pfam	PF07840 PF00392
PRINTS	PR00035
SMART	SM00345
SUPFAM	SSF48008
TIGRFAMs	TIGR02812
PROSITE	PS50949

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0019217	regulation of fatty acid metabolic process	PMID:11566998	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P0A6Q3 UniProtKB:P0A953	P		Seeded From UniProt	complete
involved_in	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:11566998	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0019217	regulation of fatty acid metabolic process	PMID:11566998	ECO:0000316		UniProtKB:P0A6Q3 UniProtKB:P0A953	P		Table 3: fabA mutants compromised in catalytic efficiency are synthetically lethal with null fadR mutations. fabB mutants compromised in catalytic efficiency are also synthetically lethal with null fadR mutations.	complete CACAO 5269
involved_in	GO:0019217	regulation of fatty acid metabolic process	PMID:11566998	ECO:0000316	genetic interaction evidence used in manual assertion		P		Seeded From UniProt	Missing: with/from
	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:11566998	ECO:0000315			P		Figure 1: fadR null mutants were shown to be significantly more susceptible than wild-type strains to cerulenin, a specific 3-ketoacyl-ACP synthase inhibitor. The fatty acid biosynthetic genes fabB and fabF both code for 3-ketoacyl-ACP synthases, but FabB (synthase I) is sevenfold more sensitive than FabF (synthase II) to cerulenin in vitro.	complete CACAO 5416
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11279025	ECO:0000250	sequence similarity evidence used in manual assertion	PDB:1CGP PDB:1QPI	P		Seeded From UniProt	complete
	GO:0045723	positive regulation of fatty acid biosynthetic process	PMID:11566998	ECO:0000315			P		Results under heading "Decreased expression of fabB in fadR strains": The promoter of the fatty acid biosynthetic gene fabB was transcriptionally fused with a promoterless CAT gene. CAT confers resistance to chloramphenicol. A strain with the transcriptional fusion and a fadR null mutation tolerated significantly lower levels of chloramphenicol than the strain with the transcriptional fusion and a functional fadR gene.	complete CACAO 5417
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11279025	ECO:0000250	sequence similarity evidence used in manual assertion	PDB:1CGP PDB:1QPI	P		Seeded From UniProt	complete
involved_in	GO:0019395	fatty acid oxidation	PMID:11279025	ECO:0000269	experimental evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18304323	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11279025	ECO:0000250	sequence similarity evidence used in manual assertion	PDB:1CGP PDB:1QPI	F		Seeded From UniProt	complete
enables	GO:0000062	fatty-acyl-CoA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014178 InterPro:IPR028374	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014178	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000524 InterPro:IPR014178	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000524	P		Seeded From UniProt	complete
involved_in	GO:0019217	regulation of fatty acid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014178 InterPro:IPR028374	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000065677	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000065677	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000065677	C		Seeded From UniProt	complete
involved_in	GO:0019217	regulation of fatty acid metabolic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000065677	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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References

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