ECOLI:ALKB

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	alkB (synonyms: aidD)
Protein Name(s)	Alpha-ketoglutarate-dependent dioxygenase AlkB Alkylated DNA repair protein AlkB DNA oxidative demethylase AlkB
External Links
UniProt	P05050
EMBL	J02607 U00008 U00096 AP009048 M10315
PIR	A24605
RefSeq	NP_416716.1 YP_490450.1
PDB	2FD8 2FDF 2FDG 2FDH 2FDI 2FDJ 2FDK 3BI3 3BIE 3BKZ 3I2O 3I3M 3I3Q 3I49 3KHB 3KHC 3O1M 3O1O 3O1P 3O1R 3O1S 3O1T 3O1U 3O1V 3T3Y 3T4H 3T4V 4JHT 4NID 4NIG 4NIH 4NII
PDBsum	2FD8 2FDF 2FDG 2FDH 2FDI 2FDJ 2FDK 3BI3 3BIE 3BKZ 3I2O 3I3M 3I3Q 3I49 3KHB 3KHC 3O1M 3O1O 3O1P 3O1R 3O1S 3O1T 3O1U 3O1V 3T3Y 3T4H 3T4V 4JHT 4NID 4NIG 4NIH 4NII
ProteinModelPortal	P05050
SMR	P05050
DIP	DIP-9085N
IntAct	P05050
MINT	MINT-1258339
STRING	511145.b2212
EnsemblBacteria	AAC75272 BAA15995
GeneID	12932924 946708
KEGG	ecj:Y75_p2173 eco:b2212
PATRIC	32119783
EchoBASE	EB0036
EcoGene	EG10037
eggNOG	COG3145
HOGENOM	HOG000122276
InParanoid	P05050
KO	K03919
OMA	SDPLQRI
OrthoDB	EOG62G5PV
PhylomeDB	P05050
BioCyc	EcoCyc:EG10037-MONOMER ECOL316407:JW2200-MONOMER MetaCyc:EG10037-MONOMER
EvolutionaryTrace	P05050
PRO	PR:P05050
Proteomes	UP000000318 UP000000625
Genevestigator	P05050
GO	GO:0051747 GO:0051213 GO:0043734 GO:0008198 GO:0035515 GO:0006307 GO:0080111 GO:0006281 GO:0070989 GO:0035552 GO:0035553 GO:0042245
Gene3D	2.60.120.590
InterPro	IPR004574 IPR027450 IPR005123
Pfam	PF13532
TIGRFAMs	TIGR00568
PROSITE	PS51471

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0080111	DNA demethylation	PMID:16482161^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070989	oxidative demethylation	PMID:16482161^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043734	DNA-N1-methyladenine dioxygenase activity	PMID:21068844^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0043734	DNA-N1-methyladenine dioxygenase activity	PMID:12594517^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0043734	DNA-N1-methyladenine dioxygenase activity	PMID:16482161^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0042245	RNA repair	PMID:12594517^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035553	oxidative single-stranded RNA demethylation	PMID:12594517^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035552	oxidative single-stranded DNA demethylation	PMID:12594517^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035515	oxidative RNA demethylase activity	PMID:12594517^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	PMID:16482161^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	PMID:12594517^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	PMID:16482161^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10037 PANTHER:PTN001819089	F	Seeded From UniProt	complete
enables	GO:0043734	DNA-N1-methyladenine dioxygenase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10037 PANTHER:PTN000421934	F	Seeded From UniProt	complete
involved_in	GO:0042245	RNA repair	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10037 PANTHER:PTN000421934	P	Seeded From UniProt	complete
involved_in	GO:0035552	oxidative single-stranded DNA demethylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10037 PANTHER:PTN000421934	P	Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10037 PANTHER:PTN001819089 UniProtKB:Q13686	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10037 PANTHER:PTN000421934	P	Seeded From UniProt	complete
involved_in	GO:0070989	oxidative demethylation	PMID:12226668^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	PMID:12226667^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	PMID:12226667^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	PMID:12226667^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	PMID:12226667^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:6337994^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005123	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004574 InterPro:IPR005123	P	Seeded From UniProt	complete
enables	GO:0103053	1-ethyladenine demethylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.11.33	F	Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0223	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Yu, B et al. (2006) Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature 439 879-84 PubMed GONUTS page
↑ Yi, C et al. (2010) Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature 468 330-3 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Aas, PA et al. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature 421 859-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Falnes, PØ et al. (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419 178-82 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Trewick, SC et al. (2002) Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419 174-8 PubMed GONUTS page
↑ Kataoka, H et al. (1983) A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate. J. Bacteriol. 153 1301-7 PubMed GONUTS page

[PMID:16482161-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Yu, B et al. (2006) Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature 439 879-84 PubMed GONUTS page

[PMID:21068844-2] Yi, C et al. (2010) Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature 468 330-3 PubMed GONUTS page

[PMID:12594517-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Aas, PA et al. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature 421 859-63 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12226668-5] Falnes, PØ et al. (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419 178-82 PubMed GONUTS page

[PMID:12226667-6] 6.0 ^6.1 ^6.2 ^6.3 Trewick, SC et al. (2002) Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419 174-8 PubMed GONUTS page

[PMID:6337994-7] Kataoka, H et al. (1983) A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate. J. Bacteriol. 153 1301-7 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

ECOLI:ALKB

Contents

Annotations

Notes

References

1

b

d

e

f

g

m

o

p

r

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools