ECOLI:3MG2

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	alkA (synonyms: aidA)
Protein Name(s)	DNA-3-methyladenine glycosylase 2 3-methyladenine-DNA glycosylase II, inducible TAG II DNA-3-methyladenine glycosidase II DNA-3-methyladenine glycosylase II
External Links
UniProt	P04395
EMBL	K02498 U00096 AP009048 M13827
PIR	A00904
RefSeq	NP_416572.1 YP_490310.1
PDB	1DIZ 1MPG 1PVS 3CVS 3CVT 3CW7 3CWA 3CWS 3CWT 3CWU 3D4V 3OGD 3OH6 3OH9
PDBsum	1DIZ 1MPG 1PVS 3CVS 3CVT 3CW7 3CWA 3CWS 3CWT 3CWU 3D4V 3OGD 3OH6 3OH9
ProteinModelPortal	P04395
SMR	P04395
DIP	DIP-9084N
IntAct	P04395
MINT	MINT-1227621
STRING	511145.b2068
EnsemblBacteria	AAC75129 BAA15926
GeneID	12930687 947371
KEGG	ecj:Y75_p2031 eco:b2068
PATRIC	32119469
EchoBASE	EB1204
EcoGene	EG11222
eggNOG	COG0122
HOGENOM	HOG000221908
InParanoid	P04395
KO	K01247
OMA	LHIWYTD
OrthoDB	EOG61VZ6W
PhylomeDB	P04395
BioCyc	EcoCyc:EG11222-MONOMER ECOL316407:JW2053-MONOMER MetaCyc:EG11222-MONOMER
EvolutionaryTrace	P04395
PRO	PR:P04395
Proteomes	UP000000318 UP000000625
Genevestigator	P04395
GO	GO:0005737 GO:0003905 GO:0008725 GO:0052822 GO:0052821 GO:0043916 GO:0006284 GO:0006974 GO:0006307 GO:0006281
Gene3D	1.10.1670.10 1.10.340.30 3.30.310.20
InterPro	IPR010316 IPR000035 IPR011257 IPR003265 IPR023170
Pfam	PF06029 PF00730
SMART	SM01009 SM00478
SUPFAM	SSF48150
PROSITE	PS00516

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0043916	DNA-7-methylguanine glycosylase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002452908 PomBase:SPAPB24D3.04c	F	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002452908 PomBase:SPAPB24D3.04c	C	Seeded From UniProt	complete
enables	GO:0032131	alkylated DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002452908 PomBase:SPAPB24D3.04c	F	Seeded From UniProt	complete
enables	GO:0008725	DNA-3-methyladenine glycosylase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002452908 PomBase:SPAPB24D3.04c SGD:S000000944	F	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11222 PANTHER:PTN002452908 PomBase:SPAPB24D3.04c SGD:S000000944 UniProtKB:P9WJW3	P	Seeded From UniProt	complete
involved_in	GO:0006285	base-excision repair, AP site formation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002452908 PomBase:SPAPB24D3.04c PomBase:SPBC23G7.11 SGD:S000000944	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11222 PANTHER:PTN001614559	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:3536857^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006307	DNA dealkylation involved in DNA repair	PMID:3536857^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:7982966^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:7982966^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7982966^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003905	alkylbase DNA N-glycosylase activity	PMID:7982966^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003905	alkylbase DNA N-glycosylase activity	PMID:3536857^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011257	F	Seeded From UniProt	complete
enables	GO:0003905	alkylbase DNA N-glycosylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000035	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000035 InterPro:IPR011257	P	Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003265	P	Seeded From UniProt	complete
enables	GO:0003905	alkylbase DNA N-glycosylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.2.21	F	Seeded From UniProt	complete
enables	GO:0052822	DNA-3-methylguanine glycosylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.2.21	F	Seeded From UniProt	complete
enables	GO:0008725	DNA-3-methyladenine glycosylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.2.21	F	Seeded From UniProt	complete
enables	GO:0043916	DNA-7-methylguanine glycosylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.2.21	F	Seeded From UniProt	complete
enables	GO:0052821	DNA-7-methyladenine glycosylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.2.21	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Kaasen, I et al. (1986) Amplified expression of the tag+ and alkA+ genes in Escherichia coli: identification of gene products and effects on alkylation resistance. J. Bacteriol. 168 642-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Bjelland, S et al. (1994) DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli. J. Biol. Chem. 269 30489-95 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:3536857-2] 2.0 ^2.1 ^2.2 Kaasen, I et al. (1986) Amplified expression of the tag+ and alkA+ genes in Escherichia coli: identification of gene products and effects on alkylation resistance. J. Bacteriol. 168 642-7 PubMed GONUTS page

[PMID:7982966-3] 3.0 ^3.1 ^3.2 ^3.3 Bjelland, S et al. (1994) DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli. J. Biol. Chem. 269 30489-95 PubMed GONUTS page

[1]

[2]

[3]

ECOLI:3MG2

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

p

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools