ECOHS:A8A1T9

Species (Taxon ID)	Escherichia coli O9:H4 (strain HS). (331112)
Gene Name(s)	alkA (ECO:0000313 with EMBL:ABV06493.1)
Protein Name(s)	DNA-3-methyladenine glycosylase 2 (ECO:0000313 with EMBL:ABV06493.1)
External Links
UniProt	A8A1T9
EMBL	CP000802
RefSeq	YP_001458876.1
ProteinModelPortal	A8A1T9
SMR	A8A1T9
STRING	331112.EcHS_A2209
EnsemblBacteria	ABV06493
GeneID	5592491
KEGG	ecx:EcHS_A2209
PATRIC	18314394
eggNOG	COG0122
HOGENOM	HOG000221908
KO	K01247
OMA	LHIWYTD
OrthoDB	EOG61VZ6W
BioCyc	ECOL331112:GHHI-2193-MONOMER
Proteomes	UP000001123
GO	GO:0008725 GO:0052822 GO:0052821 GO:0043916 GO:0006284
Gene3D	1.10.1670.10 1.10.340.30 3.30.310.20
InterPro	IPR010316 IPR000035 IPR011257 IPR003265 IPR023170
Pfam	PF06029 PF00730
SMART	SM01009 SM00478
SUPFAM	SSF48150
PROSITE	PS00516

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003905	alkylbase DNA N-glycosylase activity	PMID:24098441	IMP: Inferred from Mutant Phenotype		F	Figure 4. Promoter induction based on fluorescence intensities of GFP protein for the P. putida wt (A, B), P. putida.	complete CACAO 8966
	GO:0003905	alkylbase DNA N-glycosylase activity	PMID:24098441	IMP: Inferred from Mutant Phenotype		F	Figure 6. Survival of P. putida (A, C) and E. coli (B, D) mutants defective in alkA, alkB, and ada genes treated with 20 mM MMS (A, B) or 5 µg/ml MNNG (C, D) for the indicated time.	complete CACAO 8967
	GO:0003905	alkylbase DNA N-glycosylase activity	PMID:24098441	IMP: Inferred from Mutant Phenotype		F	Figure 9. Dependence of 3meC repair by PpAlkB on the reaction temperature.. From: Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA - In Vivo, In Vitro, and In Silico Studies.	complete CACAO 8968
	GO:0003905	alkylbase DNA N-glycosylase activity	PMID:24098441	IMP: Inferred from Mutant Phenotype		F	Figure 7. Frequency of MMS (A, B) or MNNG (C, D)-induced RifR mutations in P. putida (A, C) and E. coli (B, D) strains.. From: Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA - In Vivo, In Vitro, and In Silico Studies.	complete CACAO 8969
	GO:0003905	alkylbase DNA N-glycosylase activity	PMID:24098441	IMP: Inferred from Mutant Phenotype		F	Figure 10. The pH dependence of repair rates of the studied adducts by PpAlkB protein.. From: Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA - In Vivo, In Vitro, and In Silico Studies.	complete CACAO 8970
	GO:0003905	alkylbase DNA N-glycosylase activity	PMID:24098441	IDA: Inferred from Direct Assay		F	Figure 8. Complementation assay for EcAlkB protein.. From: Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA - In Vivo, In Vitro, and In Silico Studies.	complete CACAO 8971
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011257	F	Seeded From UniProt	complete
	GO:0003905	alkylbase DNA N-glycosylase activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000035	F	Seeded From UniProt	complete
	GO:0003905	alkylbase DNA N-glycosylase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.2.2.21	F	Seeded From UniProt	complete
	GO:0006281	DNA repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000035 InterPro:IPR011257	P	Seeded From UniProt	complete
	GO:0006284	base-excision repair	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003265	P	Seeded From UniProt	complete
	GO:0008152	metabolic process	GO_REF:0000038	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0326	P	Seeded From UniProt	complete
	GO:0008725	DNA-3-methyladenine glycosylase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.2.2.21	F	Seeded From UniProt	complete
	GO:0016787	hydrolase activity	GO_REF:0000038	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000038	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0326	F	Seeded From UniProt	complete
	GO:0043916	DNA-7-methylguanine glycosylase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.2.2.21	F	Seeded From UniProt	complete
	GO:0052821	DNA-7-methyladenine glycosylase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.2.2.21	F	Seeded From UniProt	complete
	GO:0052822	DNA-3-methylguanine glycosylase activity	GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.2.2.21	F	Seeded From UniProt	complete
edit table

References

See Help:References for how to manage references in GONUTS.