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ECO57:Q7DI68

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Species (Taxon ID) Escherichia coli O157:H7. (83334)
Gene Name(s) stx2 A-subunit (ECO:0000313 with EMBL:BAB33306.1)
Protein Name(s) Shiga toxin 2 A-subunit (ECO:0000313 with EMBL:BAB33306.1)

Shiga toxin 2 subunit A (ECO:0000313 with EMBL:BAB34628.1) Shiga-like toxin II A subunit encoded by bacteriophage BP-933W (ECO:0000313 with EMBL:AAG55587.1)

External Links
UniProt Q7DI68
EMBL AE005174
AB048836
AB048837
BA000007
RefSeq NP_286976.1
NP_309232.1
PDB 4M1U
PDBsum 4M1U
SMR Q7DI68
STRING 155864.Z1464
EnsemblBacteria AAG55587
BAB34628
GeneID 912807
959106
KEGG ece:Z1464
ecs:ECs1205
PATRIC 18351653
HOGENOM HOG000010102
KO K11006
OMA HISVPDV
OrthoDB EOG6BGNXJ
BioCyc ECOL386585:GJFA-1199-MONOMER
Proteomes UP000000558
UP000002519
GO GO:0030598
GO:0017148
Gene3D 3.40.420.10
4.10.470.10
InterPro IPR001574
IPR017988
IPR016138
IPR016139
IPR016331
Pfam PF00161
PIRSF PIRSF001924
SUPFAM SSF56371
PROSITE PS00275

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0017148

negative regulation of translation

PMID:19139230[1]

ECO:0000314

P

Figure 2 shows a decrease level of protein synthesis in presence of shiga toxin 2 (Stx2).

complete
CACAO 4385

GO:0031640

killing of cells of other organism

PMID:21567317[2]

ECO:0000314

P

Figure 1.

complete
CACAO 4388

involved_in

GO:0017148

negative regulation of translation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001574
InterPro:IPR016138
InterPro:IPR016331
InterPro:IPR017988
InterPro:IPR036041

P

Seeded From UniProt

complete

enables

GO:0030598

rRNA N-glycosylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001574
InterPro:IPR016138
InterPro:IPR016331
InterPro:IPR017988
InterPro:IPR036041

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Quiñones, B et al. (2009) Novel cell-based method to detect Shiga toxin 2 from Escherichia coli O157:H7 and inhibitors of toxin activity. Appl. Environ. Microbiol. 75 1410-6 PubMed GONUTS page
  2. Massey, S et al. (2011) A cell-based fluorescent assay to detect the activity of Shiga toxin and other toxins that inhibit protein synthesis. Methods Mol. Biol. 739 49-59 PubMed GONUTS page