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ECO57:HHA

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Species (Taxon ID) Escherichia coli O157:H7. (83334)
Gene Name(s) hha
Protein Name(s) Hemolysin expression-modulating protein Hha
External Links
UniProt P0ACE5
EMBL AE005174
BA000007
PIR A99693
E85543
RefSeq NP_286201.1
NP_308540.1
ProteinModelPortal P0ACE5
SMR P0ACE5
STRING 155864.Z0573
EnsemblBacteria AAG54809
BAB33936
GeneID 914617
957434
KEGG ece:Z0573
ecs:ECs0513
PATRIC 18349997
eggNOG NOG06626
HOGENOM HOG000219358
KO K05839
OMA YDKIPTA
OrthoDB EOG6CZQR6
BioCyc ECOL386585:GJFA-508-MONOMER
ECOO157:HHA-MONOMER
Proteomes UP000000558
UP000002519
GO GO:0003677
GO:1900191
GO:0006355
GO:0006351
Gene3D 1.20.1280.40
InterPro IPR007985
Pfam PF05321
SUPFAM SSF68989

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:1900191

negative regulation of single-species biofilm formation

PMID:23377937[1]

ECO:0000315

P

Figure 2 shows when you have a hha mutant, biofilm formation increases but when you complement the mutant with hha+, biofilm formation goes down, as hha is a negative regulator of biofilm production

complete
CACAO 7511

GO:2000147

positive regulation of cell motility

PMID:24465756[2]

ECO:0000315

P

Figure 1 shows that mutant strains without the hha gene exhibited significantly less motility than the wild-type parental strains.

complete
CACAO 10088

involved_in

GO:2000147

positive regulation of cell motility

PMID:24465756[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900191

negative regulation of single-species biofilm formation

PMID:23377937[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Sharma, VK & Bearson, BL (2013) Hha controls Escherichia coli O157:H7 biofilm formation by differential regulation of global transcriptional regulators FlhDC and CsgD. Appl. Environ. Microbiol. 79 2384-96 PubMed GONUTS page
  2. 2.0 2.1 Sharma, VK & Casey, TA (2014) Determining the relative contribution and hierarchy of hha and qseBC in the regulation of flagellar motility of Escherichia coli O157:H7. PLoS ONE 9 e85866 PubMed GONUTS page