GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
ECO57:EAE
Contents
| Species (Taxon ID) | Escherichia coli O157:H7. (83334) | |
| Gene Name(s) | eae (synonyms: eaeA) | |
| Protein Name(s) | Intimin
Attaching and effacing protein Eae protein Gamma-intimin | |
| External Links | ||
| UniProt | P43261 | |
| EMBL | Z11541 X60439 AF071034 AF081182 AF081183 AE005174 BA000007 U32312 L08095 | |
| PIR | C86045 G91198 I41193 | |
| RefSeq | NP_290259.1 NP_312586.1 | |
| PDB | 2ZQK 2ZWK 4E1S | |
| PDBsum | 2ZQK 2ZWK 4E1S | |
| ProteinModelPortal | P43261 | |
| SMR | P43261 | |
| STRING | 155864.Z5110 | |
| TCDB | 1.B.54.1.1 | |
| EnsemblBacteria | AAG58823 BAB37982 | |
| GeneID | 915471 960862 | |
| KEGG | ece:Z5110 ecs:ECs4559 | |
| PATRIC | 18358741 | |
| eggNOG | NOG12793 | |
| HOGENOM | HOG000217915 | |
| KO | K12790 | |
| OMA | FFLPENM | |
| OrthoDB | EOG6M9DRK | |
| BioCyc | ECOL386585:GJFA-4525-MONOMER ECOO157:EAE-MONOMER | |
| EvolutionaryTrace | P43261 | |
| Proteomes | UP000000558 UP000002519 | |
| GO | GO:0009279 GO:0016021 GO:0007155 GO:0009405 | |
| Gene3D | 2.60.40.920 3.10.100.10 | |
| InterPro | IPR003344 IPR003343 IPR016186 IPR016187 IPR024519 IPR003535 IPR013117 IPR008964 IPR018392 | |
| Pfam | PF02369 PF02368 PF11924 PF07979 PF01476 | |
| PRINTS | PR01369 | |
| SMART | SM00634 SM00635 SM00257 | |
| SUPFAM | SSF49373 SSF56436 | |
| PROSITE | PS51127 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Figure 4. shows largely intact host cells with a normal microvillus border of piglet when treated with eae mutant strain UMD619. There is no observed intimate attachment of bacteria to epithelial cells and no visible effacing of microvilli. |
complete | |||||
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Table 1. shows that eaeA negative strains were nonadherent in vitro to HEp-2 cells and unable to cause A/E lesions. |
complete | |||||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0009405 |
pathogenesis |
ECO:0000315 |
P |
Table 1. shows that pigs innoculated with UMD619 eaeA deletion strain had no observable A-E lesions in any of the animals. |
complete | |||||
|
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0009279 |
cell outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Donnenberg, MS et al. (1993) The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model. J. Clin. Invest. 92 1418-24 PubMed GONUTS page
- ↑ McKee, ML et al. (1995) Enterohemorrhagic Escherichia coli O157:H7 requires intimin to colonize the gnotobiotic pig intestine and to adhere to HEp-2 cells. Infect. Immun. 63 3739-44 PubMed GONUTS page
- ↑ Tzipori, S et al. (1995) The role of the eaeA gene in diarrhea and neurological complications in a gnotobiotic piglet model of enterohemorrhagic Escherichia coli infection. Infect. Immun. 63 3621-7 PubMed GONUTS page
