ECO44:PIC

Species (Taxon ID)	Escherichia coli O44:H18 (strain 042 / EAEC). (216592)
Gene Name(s)	pic (synonyms: she)
Protein Name(s)	Serine protease pic autotransporter Serine protease pic Serine protease pic translocator
External Links
UniProt	Q7BS42
EMBL	AF097644 FN554766
RefSeq	YP_006098864.1
MEROPS	N04.002
TCDB	1.B.12.4.5
GeneID	12885516
KEGG	elo:EC042_4593
PATRIC	36691007
eggNOG	COG3468
KO	K12684
OMA	ADNSHIA
BioCyc	ECOL216592:GCV7-4660-MONOMER
Proteomes	UP000001407
GO	GO:0009279 GO:0009986 GO:0005576 GO:0016021 GO:0042597 GO:0004252 GO:0009405
Gene3D	2.160.20.20 2.40.128.130
InterPro	IPR005546 IPR024973 IPR006315 IPR012332 IPR011050 IPR000710 IPR030396
Pfam	PF03797 PF13018 PF02395
PRINTS	PR00921
SMART	SM00869
SUPFAM	SSF103515 SSF51126
TIGRFAMs	TIGR01414
PROSITE	PS51208 PS51691

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0004175	endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030396	F		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000710	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000710	P		Seeded From UniProt	complete
	GO:0045916	negative regulation of complement activation	PMID:25583166	ECO:0000314			P		Figure 1 shows that Pic inhibits all three complement cascades, as shown by the decrease in deposition of C4b with anti-C4 antibodies. Figure 2 shows that Pic cleaves complement proteins. Figure 3 shows that Pic present in the supernatant of E.coli is also able to cleave purified complement proteins. Figure 4 shows that it cleaves complement proteins found in human serum	complete CACAO 10542
part_of	GO:0019867	outer membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006315	C		Seeded From UniProt	complete
enables	GO:0008236	serine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0720	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0042597	periplasmic space	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0574 UniProtKB-SubCell:SL-0200	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0009405	pathogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0843	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0009279	cell outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0998 UniProtKB-SubCell:SL-0040	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0310	C		Seeded From UniProt	complete
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References

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