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ECO27:EAE

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Species (Taxon ID) Escherichia coli O127:H6 (strain E2348/69 / EPEC). (574521)
Gene Name(s) eae (synonyms: eaeA)
Protein Name(s) Intimin

Attaching and effacing protein Eae protein

External Links
UniProt P19809
EMBL M58154
AF022236
FM180568
PIR I41197
RefSeq YP_002331401.1
PDB 1E5U
1F00
1F02
2MPW
PDBsum 1E5U
1F00
1F02
2MPW
ProteinModelPortal P19809
SMR P19809
IntAct P19809
STRING 574521.E2348C_3939
EnsemblBacteria CAS11487
GeneID 7063868
KEGG ecg:E2348C_3939
PATRIC 18347094
eggNOG NOG266450
KO K12790
OMA FFLPENM
BioCyc ECOL574521:GJAO-4082-MONOMER
EvolutionaryTrace P19809
Proteomes UP000008205
GO GO:0009279
GO:0016021
GO:0007155
GO:0009405
Gene3D 2.60.40.920
3.10.100.10
InterPro IPR003344
IPR003343
IPR016186
IPR016187
IPR024519
IPR003535
IPR013117
IPR008964
IPR018392
Pfam PF02369
PF02368
PF11924
PF07979
PF01476
PRINTS PR01369
SMART SM00634
SM00635
SM00257
SUPFAM SSF49373
SSF56436
PROSITE PS51127

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0009405

pathogenesis

PMID:2172966[1]

ECO:0000315

P

Figure 2. shows reduced lesions and presence of bacteria in sections treated with mutant strains.

complete
CACAO 6012

GO:0009405

pathogenesis

PMID:8376594[2]

ECO:0000315

P

Table 1. shows that lower frequency of developing diarrhea, vomiting, malaise, and anorexia for individuals who received eaeA deletion mutant in comparison to wild-type.

complete
CACAO 6021

involved_in

GO:0009405

pathogenesis

PMID:8376594[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

PMID:2172966[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003535

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0009279

cell outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0998
UniProtKB-SubCell:SL-0040

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0843

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Jerse, AE et al. (1990) A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc. Natl. Acad. Sci. U.S.A. 87 7839-43 PubMed GONUTS page
  2. 2.0 2.1 Donnenberg, MS et al. (1993) Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection. J. Clin. Invest. 92 1412-7 PubMed GONUTS page