EBVB9:RTA

Species (Taxon ID)	Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4). (10377)
Gene Name(s)	No Information Provided.
Protein Name(s)	Replication and transcription activator Rta Immediate-early protein Rta
External Links
UniProt	P03209
EMBL	V01555 AJ507799
PIR	A43043
RefSeq	YP_401674.1
IntAct	P03209
GeneID	3783727
Proteomes	UP000007640
GO	GO:0003677 GO:0006355 GO:0006351 GO:0016032
InterPro	IPR004998
Pfam	PF03326

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010628	positive regulation of gene expression	PMID:23135711	ECO:0000314			P		Figure 5A & 5C. BRLF1 can bind to both methylated and unmethylated promoters to activate lytic gene expression.	complete CACAO 7440
	GO:0019046	release from viral latency	PMID:1	ECO:0000315			P		BRLF1 is a transcriptional activator that mediates the switch from latent to lytic viral replication. Figure 1 A-C: Three different cell lines were transfected with plasmids for the over-expression of Na (which is the product of gene BRRF1) as well as control plasmids with no over-expression of Na. To see if Na initiated lysis in the cells in which Na was overproduced, immunoassays were performed to search for lytic cell products. The proteins searched for include BMRF1, Z protein, R protein, Na (through FLAG), and β-actin. In all three types of cells with plasmids over-expressing BRRF1, these lytic proteins were found in a greater amount than in the cells without the over-expression plasmids. Expression of BRRF1 leads to a product that affects maintenance of viral latency. The evidence code is IMP because there is over-expression of the gene. Presence of the gene product resulted in an increase in specific lytic proteins measured by an immunoblot assay.	complete CACAO 9654
	GO:0019046	release from viral latency	PMID:21325409	ECO:0000315			P		BRLF1 is a transcriptional activator that mediates the switch from latent to lytic viral replication. Figure 1 A-C: Three different cell lines were transfected with plasmids for the over-expression of Na (which is the product of gene BRRF1) as well as control plasmids with no over-expression of Na. To see if Na initiated lysis in the cells in which Na was overproduced, immunoassays were performed to search for lytic cell products. The proteins searched for include BMRF1, Z protein, R protein, Na (through FLAG), and β-actin. In all three types of cells with plasmids over-expressing BRRF1, these lytic proteins were found in a greater amount than in the cells without the over-expression plasmids. Expression of BRRF1 leads to a product that affects maintenance of viral latency. The evidence code is IMP because there is over-expression of the gene. Presence of the gene product resulted in an increase in specific lytic proteins measured by an immunoblot assay.	complete CACAO 9655
	GO:0019046	release from viral latency	PMID:21325409	ECO:0000315			P		Figure 1 A-C: Three different cell lines were transfected with plasmids for the over-expression of Na (which is the product of gene BRRF1) as well as control plasmids with no over-expression of Na. To see if Na initiated lysis in the cells in which Na was overproduced, immunoassays were performed to search for lytic cell products. The proteins searched for include BMRF1, Z protein, R protein, Na (through FLAG), and β-actin. In all three types of cells with plasmids over-expressing BRRF1, these lytic proteins were found in a greater amount than in the cells without the over-expression plasmids. Expression of BRRF1 leads to a product that affects maintenance of viral latency. The evidence code is IMP because there is over-expression of the gene. Presence of the gene product resulted	complete CACAO 9669
	GO:0050434	positive regulation of viral transcription	PMID:17446270	ECO:0000314			P		Figure 2: Rta causes 6 to 33 fold increase in the actively of four target EBV gene promoters.	complete CACAO 9689
involved_in	GO:0050434	positive regulation of viral transcription	PMID:17446270	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004998	P		Seeded From UniProt	complete
involved_in	GO:0019042	viral latency	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1251	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0019046	release from viral latency	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1272	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
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