EBVB9:EAR

Species (Taxon ID)	Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4). (10377)
Gene Name(s)	No Information Provided.
Protein Name(s)	Apoptosis regulator BHRF1 Early antigen protein R EA-R Nuclear antigen
External Links
UniProt	P03182
EMBL	M17416 V01555 M17293 AJ507799 EF192979
PIR	C93065
RefSeq	YP_401646.1
PDB	1Q59 2XPX
PDBsum	1Q59 2XPX
ProteinModelPortal	P03182
SMR	P03182
DIP	DIP-39168N
IntAct	P03182
MINT	MINT-199358
GeneID	3783706
EvolutionaryTrace	P03182
Proteomes	UP000007640
GO	GO:0033644 GO:0033650 GO:0016021 GO:0006915 GO:0033668 GO:0090201
InterPro	IPR002475 IPR020726 IPR026298
Pfam	PF00452
PROSITE	PS50062 PS01258

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	PMID:18084238	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0042981	regulation of apoptotic process	PMID:12270148	ECO:0000314			P		Fig. 2 shows that in the presence of BHRF1 apoptosis is inhibited.	complete CACAO 4736
involved_in	GO:0033668	negative regulation by symbiont of host apoptotic process	PMID:18084238	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0033668	negative regulation by symbiont of host apoptotic process	PMID:18084238	ECO:0000314			P		Figure 4 shows significantly lower %apoptosis in cells with the BHRF-1 regulator.	complete CACAO 5034
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020726 InterPro:IPR026298 InterPro:IPR036834	P		Seeded From UniProt	complete
	GO:0090201	negative regulation of release of cytochrome c from mitochondria	PMID:18084238	ECO:0000314			P		Figure 6C shows the measurements of release of cytochrome C. When BHRF-1 and KSHV BCL-2 were introduced, cytochrome c release was reduced.	complete CACAO 5154
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0033650	host cell mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1045 UniProtKB-SubCell:SL-0407	C		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043 UniProtKB-SubCell:SL-0380	C		Seeded From UniProt	complete
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References

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