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EBVB9:BZLF1
Contents
| Species (Taxon ID) | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4). (10377) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | Trans-activator protein BZLF1
EB1 Zebra | |
| External Links | ||
| UniProt | P03206 | |
| EMBL | V01555 AJ507799 M17547 | |
| RefSeq | YP_401673.1 | |
| PDB | 1ZSD 2AK4 2AXF 2AXG 2C9L 2C9N 2NX5 3KWW 3KXF 3SPV 3VFN 3VFO 3VFP 3VFR | |
| PDBsum | 1ZSD 2AK4 2AXF 2AXG 2C9L 2C9N 2NX5 3KWW 3KXF 3SPV 3VFN 3VFO 3VFP 3VFR | |
| ProteinModelPortal | P03206 | |
| SMR | P03206 | |
| IntAct | P03206 | |
| MINT | MINT-6768270 | |
| BindingDB | P03206 | |
| ChEMBL | CHEMBL1293280 | |
| GeneID | 3783744 | |
| EvolutionaryTrace | P03206 | |
| Proteomes | UP000007640 | |
| GO | GO:0042025 GO:0043565 GO:0003700 GO:0039646 GO:0039557 GO:0006351 | |
| InterPro | IPR004827 IPR017339 | |
| Pfam | PF00170 | |
| PIRSF | PIRSF037966 | |
| SMART | SM00338 | |
| PROSITE | PS00036 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
P |
Fig 1: DNA methylation enhances BZLF1 transactivation of most early lytic EBV promoters. This proves BZLF1 has a major affect on EBV entering the lytic cycle. |
complete | |||||
|
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019042 |
viral latency |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060153 |
modulation by virus of host cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039557 |
suppression by virus of host IRF7 activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019046 |
release from viral latency |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039646 |
modulation by virus of host G0/G1 transition checkpoint |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Wille, CK et al. (2013) Viral genome methylation differentially affects the ability of BZLF1 versus BRLF1 to activate Epstein-Barr virus lytic gene expression and viral replication. J. Virol. 87 935-50 PubMed GONUTS page
- ↑ Farrell, PJ et al. (1989) Epstein-Barr virus BZLF1 trans-activator specifically binds to a consensus AP-1 site and is related to c-fos. EMBO J. 8 127-32 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Schelcher, C et al. (2007) Atypical bZIP domain of viral transcription factor contributes to stability of dimer formation and transcriptional function. J. Virol. 81 7149-55 PubMed GONUTS page
- ↑ Packham, G et al. (1990) Structure and function of the Epstein-Barr virus BZLF1 protein. J. Virol. 64 2110-6 PubMed GONUTS page
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