DROME:VND

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	vnd (synonyms: NK2)
Protein Name(s)	Homeobox protein vnd Homeobox protein NK-2 Protein ventral nervous system defective
External Links
UniProt	P22808
EMBL	X87141 S78691 AE014298 AL031883 M27290
PIR	S57246
RefSeq	NP_476786.2
PDB	1NK2 1NK3 1QRY 1VND
PDBsum	1NK2 1NK3 1QRY 1VND
ProteinModelPortal	P22808
SMR	P22808
BioGrid	57572
DIP	DIP-60882N
IntAct	P22808
MINT	MINT-283656
EnsemblMetazoa	FBtr0070110
GeneID	31003
KEGG	dme:Dmel_CG6172
CTD	31003
FlyBase	FBgn0261930
eggNOG	NOG310976
GeneTree	ENSGT00760000118779
InParanoid	P22808
KO	K08029
OMA	PILLPPW
OrthoDB	EOG769ZK0
PhylomeDB	P22808
Reactome	REACT_249175
EvolutionaryTrace	P22808
GenomeRNAi	31003
NextBio	771420
Proteomes	UP000000803
Bgee	P22808
ExpressionAtlas	P22808
GO	GO:0005634 GO:0043565 GO:0000981 GO:0008134 GO:0007420 GO:0007417 GO:0009953 GO:0007398 GO:0021782 GO:0010629 GO:0000122 GO:0014019 GO:0007400 GO:0007389 GO:0045944 GO:0006357 GO:0006366 GO:0007419
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR009057
Pfam	PF00046
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004110 FB:FBgn0004862 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:97347 MGI:MGI:97348 MGI:MGI:97350 PANTHER:PTN000678271 RGD:3866 UniProtKB:A6NCS4 UniProtKB:A6NJ46 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801 WB:WBGene00000445 WB:WBGene00000450	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0004110 FB:FBgn0004862 MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:1310629 RGD:3866 RGD:620520 RGD:69318 UniProtKB:A6NCS4 UniProtKB:A6NJ46 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801 WB:WBGene00000445	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0002941 FB:FBgn0004110 FB:FBgn0028993 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1206039 MGI:MGI:1270158 MGI:MGI:1352738 MGI:MGI:1921811 MGI:MGI:97347 MGI:MGI:97348 MGI:MGI:97350 MGI:MGI:97351 PANTHER:PTN000678271 RGD:620520 RGD:69318 UniProtKB:P52952 WB:WBGene00000445 WB:WBGene00000584 ZFIN:ZDB-GENE-030328-42 ZFIN:ZDB-GENE-040718-178 ZFIN:ZDB-GENE-050217-3 ZFIN:ZDB-GENE-070626-1 ZFIN:ZDB-GENE-980526-321 ZFIN:ZDB-GENE-980526-403 ZFIN:ZDB-GENE-990415-179	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000576 FB:FBgn0002941 FB:FBgn0004110 FB:FBgn0004862 FB:FBgn0040318 FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:1206039 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:1308443 RGD:1310629 RGD:3866 RGD:620520 RGD:69318 UniProtKB:F1NC42 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q90788 UniProtKB:Q99801 WB:WBGene00000445	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261930 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97347 MGI:MGI:97350 MGI:MGI:97352 PANTHER:PTN000678271 RGD:3866 RGD:69318 UniProtKB:A6NCS4 UniProtKB:O15522 UniProtKB:P43699 UniProtKB:P52952 UniProtKB:Q99801	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108015 MGI:MGI:108067 MGI:MGI:1352738 MGI:MGI:97350 PANTHER:PTN000678271 RGD:69318 UniProtKB:O15522 UniProtKB:P52952 UniProtKB:Q99801	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21764853^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:20673828^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17646657^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0014019	neuroblast development	PMID:17038517^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0021782	glial cell development	PMID:17038517^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:17038518^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:17360441^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17360441^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17360441^[7]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0000411	F	Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:15266339^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:15266339^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007419	ventral cord development	PMID:12027434^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9832510^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:9832510^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007400	neuroblast fate determination	PMID:8050360^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
involved_in	GO:0007400	neuroblast fate determination	PMID:15221856^[12] PMID:12593977^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007398	ectoderm development	PMID:15221856^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	PMID:15221856^[12] PMID:12593977^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:15221856^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007419	ventral cord development	PMID:12593977^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0371 UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Weake, VM et al. (2011) Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. Genes Dev. 25 1499-509 PubMed GONUTS page
↑ Seibert, J & Urbach, R (2010) Role of en and novel interactions between msh, ind, and vnd in dorsoventral patterning of the Drosophila brain and ventral nerve cord. Dev. Biol. 346 332-45 PubMed GONUTS page
↑ Sharma, SK & Nirenberg, M (2007) Silencing of genes in cultured Drosophila neurons by RNA interference. Proc. Natl. Acad. Sci. U.S.A. 104 12925-30 PubMed GONUTS page
↑ ^5.0 ^5.1 Urbach, R et al. (2006) Segment-specific requirements for dorsoventral patterning genes during early brain development in Drosophila. Development 133 4315-30 PubMed GONUTS page
↑ Sprecher, SG et al. (2006) The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila. Development 133 4331-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Zhao, G et al. (2007) Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS. Proc. Natl. Acad. Sci. U.S.A. 104 3847-52 PubMed GONUTS page
↑ ^8.0 ^8.1 Ball, EE et al. (2004) A simple plan--cnidarians and the origins of developmental mechanisms. Nat. Rev. Genet. 5 567-77 PubMed GONUTS page
↑ Stathopoulos, A & Levine, M (2002) Dorsal gradient networks in the Drosophila embryo. Dev. Biol. 246 57-67 PubMed GONUTS page
↑ ^10.0 ^10.1 Weiss, JB et al. (1998) Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity. Genes Dev. 12 3591-602 PubMed GONUTS page
↑ Skeath, JB et al. (1994) The ventral nervous system defective gene controls proneural gene expression at two distinct steps during neuroblast formation in Drosophila. Development 120 1517-24 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Urbach, R & Technau, GM (2004) Neuroblast formation and patterning during early brain development in Drosophila. Bioessays 26 739-51 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Skeath, JB & Thor, S (2003) Genetic control of Drosophila nerve cord development. Curr. Opin. Neurobiol. 13 8-15 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21764853-2] Weake, VM et al. (2011) Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. Genes Dev. 25 1499-509 PubMed GONUTS page

[PMID:20673828-3] Seibert, J & Urbach, R (2010) Role of en and novel interactions between msh, ind, and vnd in dorsoventral patterning of the Drosophila brain and ventral nerve cord. Dev. Biol. 346 332-45 PubMed GONUTS page

[PMID:17646657-4] Sharma, SK & Nirenberg, M (2007) Silencing of genes in cultured Drosophila neurons by RNA interference. Proc. Natl. Acad. Sci. U.S.A. 104 12925-30 PubMed GONUTS page

[PMID:17038517-5] 5.0 ^5.1 Urbach, R et al. (2006) Segment-specific requirements for dorsoventral patterning genes during early brain development in Drosophila. Development 133 4315-30 PubMed GONUTS page

[PMID:17038518-6] Sprecher, SG et al. (2006) The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila. Development 133 4331-9 PubMed GONUTS page

[PMID:17360441-7] 7.0 ^7.1 ^7.2 Zhao, G et al. (2007) Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS. Proc. Natl. Acad. Sci. U.S.A. 104 3847-52 PubMed GONUTS page

[PMID:15266339-8] 8.0 ^8.1 Ball, EE et al. (2004) A simple plan--cnidarians and the origins of developmental mechanisms. Nat. Rev. Genet. 5 567-77 PubMed GONUTS page

[PMID:12027434-9] Stathopoulos, A & Levine, M (2002) Dorsal gradient networks in the Drosophila embryo. Dev. Biol. 246 57-67 PubMed GONUTS page

[PMID:9832510-10] 10.0 ^10.1 Weiss, JB et al. (1998) Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity. Genes Dev. 12 3591-602 PubMed GONUTS page

[PMID:8050360-11] Skeath, JB et al. (1994) The ventral nervous system defective gene controls proneural gene expression at two distinct steps during neuroblast formation in Drosophila. Development 120 1517-24 PubMed GONUTS page

[PMID:15221856-12] 12.0 ^12.1 ^12.2 ^12.3 Urbach, R & Technau, GM (2004) Neuroblast formation and patterning during early brain development in Drosophila. Bioessays 26 739-51 PubMed GONUTS page

[PMID:12593977-13] 13.0 ^13.1 ^13.2 Skeath, JB & Thor, S (2003) Genetic control of Drosophila nerve cord development. Curr. Opin. Neurobiol. 13 8-15 PubMed GONUTS page

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DROME:VND

Contents

Annotations

Notes

References

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