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DROME:TORS

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Torsin (synonyms: torp4a)
Protein Name(s) Torsin-like protein
External Links
UniProt O77277
EMBL AM999060
AM999061
AM999062
AM999063
AM999064
AM999065
AM999066
AM999067
AM999068
AM999069
FM246173
FM246174
FM246175
FM246176
FM246177
FM246178
FM246179
FM246180
FM246181
FM246182
FM246183
FM246184
AF236156
AE014298
AL031766
AY069592
BT003553
RefSeq NP_001284866.1
NP_572178.1
UniGene Dm.19668
ProteinModelPortal O77277
BioGrid 57916
PaxDb O77277
PRIDE O77277
EnsemblMetazoa FBtr0070690
GeneID 31399
KEGG dme:Dmel_CG3024
UCSC CG3024-RA
CTD 31399
FlyBase FBgn0025615
eggNOG NOG283963
GeneTree ENSGT00390000001920
InParanoid O77277
OMA YFPREER
OrthoDB EOG7TF791
PhylomeDB O77277
GenomeRNAi 31399
NextBio 773452
Proteomes UP000000803
Bgee O77277
ExpressionAtlas O77277
GO GO:0005788
GO:0005524
GO:0048085
GO:0051085
GO:0040011
GO:0043104
GO:0042053
Gene3D 3.40.50.300
InterPro IPR027417
IPR010448
IPR017378
PANTHER PTHR10760
Pfam PF06309
PIRSF PIRSF038079
SUPFAM SSF52540

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007504

larval fat body development

PMID:27453503[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044255

cellular lipid metabolic process

PMID:27453503[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070328

triglyceride homeostasis

PMID:27453503[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903741

negative regulation of phosphatidate phosphatase activity

PMID:27453503[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030307

positive regulation of cell growth

PMID:27453503[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010883

regulation of lipid storage

PMID:27453503[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046467

membrane lipid biosynthetic process

PMID:27453503[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:23583177[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071426

ribonucleoprotein complex export from nucleus

PMID:23583177[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:23583177[2]

ECO:0000255

match to sequence model evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

enables

GO:0016887

ATPase activity

PMID:23583177[2]

ECO:0000255

match to sequence model evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

involved_in

GO:0040011

locomotion

PMID:22022556[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043104

positive regulation of GTP cyclohydrolase I activity

PMID:22022556[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042053

regulation of dopamine metabolic process

PMID:22022556[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048085

adult chitin-containing cuticle pigmentation

PMID:22022556[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:16967506[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008057

eye pigment granule organization

PMID:16967506[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070050

neuron cellular homeostasis

PMID:16967506[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:16967506[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010448
InterPro:IPR017378
InterPro:IPR030553

F

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030553

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017378
InterPro:IPR030553

C

Seeded From UniProt

complete

involved_in

GO:0051085

chaperone cofactor-dependent protein refolding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017378

P

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0096

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Grillet, M et al. (2016) Torsins Are Essential Regulators of Cellular Lipid Metabolism. Dev. Cell 38 235-47 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Jokhi, V et al. (2013) Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope. Cell Rep 3 988-95 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Wakabayashi-Ito, N et al. (2011) Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism. PLoS ONE 6 e26183 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Muraro, NI & Moffat, KG (2006) Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. J. Neurobiol. 66 1338-53 PubMed GONUTS page