DROME:TORS

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Torsin (synonyms: torp4a)
Protein Name(s)	Torsin-like protein
External Links
UniProt	O77277
EMBL	AM999060 AM999061 AM999062 AM999063 AM999064 AM999065 AM999066 AM999067 AM999068 AM999069 FM246173 FM246174 FM246175 FM246176 FM246177 FM246178 FM246179 FM246180 FM246181 FM246182 FM246183 FM246184 AF236156 AE014298 AL031766 AY069592 BT003553
RefSeq	NP_001284866.1 NP_572178.1
UniGene	Dm.19668
ProteinModelPortal	O77277
BioGrid	57916
PaxDb	O77277
PRIDE	O77277
EnsemblMetazoa	FBtr0070690
GeneID	31399
KEGG	dme:Dmel_CG3024
UCSC	CG3024-RA
CTD	31399
FlyBase	FBgn0025615
eggNOG	NOG283963
GeneTree	ENSGT00390000001920
InParanoid	O77277
OMA	YFPREER
OrthoDB	EOG7TF791
PhylomeDB	O77277
GenomeRNAi	31399
NextBio	773452
Proteomes	UP000000803
Bgee	O77277
ExpressionAtlas	O77277
GO	GO:0005788 GO:0005524 GO:0048085 GO:0051085 GO:0040011 GO:0043104 GO:0042053
Gene3D	3.40.50.300
InterPro	IPR027417 IPR010448 IPR017378
PANTHER	PTHR10760
Pfam	PF06309
PIRSF	PIRSF038079
SUPFAM	SSF52540

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0007504	larval fat body development	PMID:27453503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044255	cellular lipid metabolic process	PMID:27453503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070328	triglyceride homeostasis	PMID:27453503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1903741	negative regulation of phosphatidate phosphatase activity	PMID:27453503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:27453503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010883	regulation of lipid storage	PMID:27453503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046467	membrane lipid biosynthetic process	PMID:27453503^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:23583177^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0071426	ribonucleoprotein complex export from nucleus	PMID:23583177^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:23583177^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
enables	GO:0016887	ATPase activity	PMID:23583177^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
involved_in	GO:0040011	locomotion	PMID:22022556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043104	positive regulation of GTP cyclohydrolase I activity	PMID:22022556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042053	regulation of dopamine metabolic process	PMID:22022556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048085	adult chitin-containing cuticle pigmentation	PMID:22022556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:16967506^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0008057	eye pigment granule organization	PMID:16967506^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070050	neuron cellular homeostasis	PMID:16967506^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:16967506^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010448 InterPro:IPR017378 InterPro:IPR030553	F	Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030553	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017378 InterPro:IPR030553	C	Seeded From UniProt	complete
involved_in	GO:0051085	chaperone cofactor-dependent protein refolding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017378	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0096	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Grillet, M et al. (2016) Torsins Are Essential Regulators of Cellular Lipid Metabolism. Dev. Cell 38 235-47 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Jokhi, V et al. (2013) Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope. Cell Rep 3 988-95 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Wakabayashi-Ito, N et al. (2011) Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism. PLoS ONE 6 e26183 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Muraro, NI & Moffat, KG (2006) Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. J. Neurobiol. 66 1338-53 PubMed GONUTS page

[PMID:27453503-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Grillet, M et al. (2016) Torsins Are Essential Regulators of Cellular Lipid Metabolism. Dev. Cell 38 235-47 PubMed GONUTS page

[PMID:23583177-2] 2.0 ^2.1 ^2.2 ^2.3 Jokhi, V et al. (2013) Torsin mediates primary envelopment of large ribonucleoprotein granules at the nuclear envelope. Cell Rep 3 988-95 PubMed GONUTS page

[PMID:22022556-3] 3.0 ^3.1 ^3.2 ^3.3 Wakabayashi-Ito, N et al. (2011) Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism. PLoS ONE 6 e26183 PubMed GONUTS page

[PMID:16967506-4] 4.0 ^4.1 ^4.2 ^4.3 Muraro, NI & Moffat, KG (2006) Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. J. Neurobiol. 66 1338-53 PubMed GONUTS page

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DROME:TORS

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