DROME:TIP60

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Tip60
Protein Name(s)	Histone acetyltransferase Tip60
External Links
UniProt	Q960X4
EMBL	AE014298 AL033125 AY051795
RefSeq	NP_001259234.1 NP_572151.1
UniGene	Dm.75
ProteinModelPortal	Q960X4
SMR	Q960X4
BioGrid	57879
IntAct	Q960X4
MINT	MINT-785367
PRIDE	Q960X4
EnsemblMetazoa	FBtr0070668 FBtr0333186
GeneID	31362
KEGG	dme:Dmel_CG6121
CTD	31362
FlyBase	FBgn0026080
eggNOG	COG5027
GeneTree	ENSGT00550000074503
InParanoid	Q960X4
KO	K11304
OMA	KHTISFF
OrthoDB	EOG7ZKS9R
PhylomeDB	Q960X4
Reactome	REACT_218447
GenomeRNAi	31362
NextBio	773249
PRO	PR:Q960X4
Proteomes	UP000000803
Bgee	Q960X4
GO	GO:0000123 GO:0035267 GO:0005634 GO:0005705 GO:0004402 GO:0006974 GO:0016573 GO:0043486 GO:0043967 GO:0043524 GO:0007399 GO:0010468 GO:0048167 GO:2000331 GO:0006355 GO:0006351
Gene3D	3.40.630.30
InterPro	IPR016181 IPR000953 IPR016197 IPR002717 IPR025995
Pfam	PF01853 PF11717
SMART	SM00298
SUPFAM	SSF54160 SSF55729
PROSITE	PS51726

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0043486	histone exchange	PMID:15528408^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0035267	NuA4 histone acetyltransferase complex	PMID:15528408^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	PMID:15528408^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:15528408^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028387 MGI:MGI:1932051 PANTHER:PTN000064894 RGD:1566399 RGD:621061 UniProtKB:O95251 UniProtKB:Q92993	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0087008 PANTHER:PTN000064894 UniProtKB:Q8WYB5 UniProtKB:Q92794 UniProtKB:Q92993 UniProtKB:Q96T23 UniProtKB:Q9H7Z6 WB:WBGene00007029	P	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000064894 UniProtKB:Q96T23	F	Seeded From UniProt	complete
part_of	GO:0032777	Piccolo NuA4 histone acetyltransferase complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000065044 SGD:S000005770 UniProtKB:Q92993	C	Seeded From UniProt	complete
enables	GO:0010485	H4 histone acetyltransferase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028387 PANTHER:PTN002239249 SGD:S000005770	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014340 FB:FBgn0026080 FB:FBgn0026577 FB:FBgn0028387 FB:FBgn0087008 MGI:MGI:109529 MGI:MGI:2442415 PANTHER:PTN000064894 RGD:1304892 RGD:1566399 RGD:621061 TAIR:locus:2144776 TAIR:locus:2144841 TAIR:locus:2169779 TAIR:locus:2174764 UniProtKB:O95251 UniProtKB:Q6ZJM9 UniProtKB:Q8III2 UniProtKB:Q8WUB8 UniProtKB:Q92794 UniProtKB:Q92993 UniProtKB:Q96T23 UniProtKB:Q9H7Z6	C	Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014340 FB:FBgn0026080 MGI:MGI:1858746 PANTHER:PTN000064894 SGD:S000000148 SGD:S000004734 SGD:S000005770 TAIR:locus:2144776 TAIR:locus:2174764 UniProtKB:Q8III2 UniProtKB:Q8WYB5 UniProtKB:Q92794 UniProtKB:Q92993 UniProtKB:Q9H7Z6 ZFIN:ZDB-GENE-021022-3	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000064894 PomBase:SPAC17G8.13c RGD:621061 SGD:S000004734 SGD:S000005770 ZFIN:ZDB-GENE-021022-3	C	Seeded From UniProt	complete
part_of	GO:0000123	histone acetyltransferase complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026080 PANTHER:PTN000064894 UniProtKB:O95251 UniProtKB:Q9H7Z6	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:29654189^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:1990188	euchromatin binding	PMID:29654189^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:22848598^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:22848598^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000331	regulation of terminal button organization	PMID:22046262^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:22046262^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	PMID:21494552^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0043967	histone H4 acetylation	PMID:21494552^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21494552^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19949809^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005705	polytene chromosome interband	PMID:19949809^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0035267	NuA4 histone acetyltransferase complex	PMID:15528408^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043486	histone exchange	PMID:15528408^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15528408^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000123	histone acetyltransferase complex	PMID:15528408^[1]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0040078	C	Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	PMID:15528408^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002717 InterPro:IPR037995	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002717	P	Seeded From UniProt	complete
involved_in	GO:0016573	histone acetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002717 InterPro:IPR037995	P	Seeded From UniProt	complete
part_of	GO:0035267	NuA4 histone acetyltransferase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR037995	C	Seeded From UniProt	complete
enables	GO:0004402	histone acetyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.48	F	Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Kusch, T et al. (2004) Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science 306 2084-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Panikker, P et al. (2018) Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition. J. Neurosci. 38 4569-4583 PubMed GONUTS page
↑ ^4.0 ^4.1 Pirooznia, SK et al. (2012) Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. PLoS ONE 7 e41776 PubMed GONUTS page
↑ ^5.0 ^5.1 Sarthi, J & Elefant, F (2011) dTip60 HAT activity controls synaptic bouton expansion at the Drosophila neuromuscular junction. PLoS ONE 6 e26202 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lorbeck, M et al. (2011) Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism. PLoS ONE 6 e18412 PubMed GONUTS page
↑ ^7.0 ^7.1 Schirling, C et al. (2010) Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60. Chromosoma 119 99-113 PubMed GONUTS page

[PMID:15528408-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Kusch, T et al. (2004) Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science 306 2084-7 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:29654189-3] 3.0 ^3.1 Panikker, P et al. (2018) Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition. J. Neurosci. 38 4569-4583 PubMed GONUTS page

[PMID:22848598-4] 4.0 ^4.1 Pirooznia, SK et al. (2012) Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. PLoS ONE 7 e41776 PubMed GONUTS page

[PMID:22046262-5] 5.0 ^5.1 Sarthi, J & Elefant, F (2011) dTip60 HAT activity controls synaptic bouton expansion at the Drosophila neuromuscular junction. PLoS ONE 6 e26202 PubMed GONUTS page

[PMID:21494552-6] 6.0 ^6.1 ^6.2 Lorbeck, M et al. (2011) Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism. PLoS ONE 6 e18412 PubMed GONUTS page

[PMID:19949809-7] 7.0 ^7.1 Schirling, C et al. (2010) Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60. Chromosoma 119 99-113 PubMed GONUTS page

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DROME:TIP60

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