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DROME:STX1A

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Syx1A (synonyms: syx-1A)
Protein Name(s) Syntaxin-1A

dSynt1

External Links
UniProt Q24547
EMBL L37732
AE014297
AY061472
PIR A55673
RefSeq NP_524475.1
UniGene Dm.2366
ProteinModelPortal Q24547
SMR Q24547
BioGrid 67788
DIP DIP-19389N
IntAct Q24547
MINT MINT-957003
PaxDb Q24547
PRIDE Q24547
EnsemblMetazoa FBtr0084588
GeneID 42854
KEGG dme:Dmel_CG31136
CTD 42854
FlyBase FBgn0013343
eggNOG COG5074
GeneTree ENSGT00760000119200
InParanoid Q24547
KO K04560
OrthoDB EOG7X9G7R
PhylomeDB Q24547
GenomeRNAi 42854
NextBio 830935
Proteomes UP000000803
Bgee Q24547
GO GO:0016021
GO:0005886
GO:0031201
GO:0008021
GO:0043195
GO:0005484
GO:0000149
GO:0007349
GO:0007482
GO:0006886
GO:0000281
GO:0007274
GO:0007269
GO:0017157
GO:0007317
GO:0016081
GO:0031629
GO:0006906
GO:0016192
InterPro IPR028669
IPR006012
IPR006011
IPR010989
IPR000727
PANTHER PTHR19957:SF84
Pfam PF05739
PF00804
SMART SM00503
SM00397
SUPFAM SSF47661
PROSITE PS00914
PS50192

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000149

SNARE binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028669

F

Seeded From UniProt

complete

GO:0000149

SNARE binding

PMID:20688915[1]

IPI: Inferred from Physical Interaction

FB:FBgn0011288
FB:FBgn0013342

F

Seeded From UniProt

complete

GO:0000281

mitotic cytokinesis

PMID:12134082[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000281

mitotic cytokinesis

PMID:15380073[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0005484

SNAP receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006012

F

Seeded From UniProt

complete

GO:0005484

SNAP receptor activity

PMID:10218158[4]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0005484

SNAP receptor activity

PMID:10908590[5]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005484

SNAP receptor activity

PMID:12414991[6]

IPI: Inferred from Physical Interaction

FB:FBgn0250791

F

Seeded From UniProt

complete

GO:0005484

SNAP receptor activity

PMID:20688915[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14605208[7]

IPI: Inferred from Physical Interaction

UniProtKB:Q23983

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16603075[8]

IPI: Inferred from Physical Interaction

UniProtKB:Q23983

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19079254[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q23983

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:20688915[1]

IPI: Inferred from Physical Interaction

FB:FBgn0004242
FB:FBgn0028400

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21316453[10]

IPI: Inferred from Physical Interaction

FB:FBgn0000346
FB:FBgn0011288
FB:FBgn0013342
FB:FBgn0250791

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:10218158[4]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:10908590[5]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005886

plasma membrane

PMID:20462449[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

complete

GO:0006836

neurotransmitter transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0532

P

Seeded From UniProt

complete

GO:0006886

intracellular protein transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006012

P

Seeded From UniProt

complete

GO:0006886

intracellular protein transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000461349

P

Seeded From UniProt

complete

GO:0006887

exocytosis

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000461524

P

Seeded From UniProt

complete

GO:0006906

vesicle fusion

PMID:20688915[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007269

neurotransmitter secretion

PMID:10798391[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007269

neurotransmitter secretion

PMID:7834751[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007274

neuromuscular synaptic transmission

PMID:21316453[10]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0007317

regulation of pole plasm oskar mRNA localization

PMID:10656772[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007349

cellularization

PMID:11700298[15]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007349

cellularization

PMID:12386932[16]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007482

haltere development

PMID:16815386[17]

IGI: Inferred from Genetic Interaction

FB:FBgn0003944

P

Seeded From UniProt

complete

GO:0008021

synaptic vesicle

PMID:7834751[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0012505

endomembrane system

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000461349

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006011
InterPro:IPR006012
InterPro:IPR010989

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028669

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000461349

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016081

synaptic vesicle docking

PMID:10908590[5]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0016192

vesicle-mediated transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010989
InterPro:IPR028669

P

Seeded From UniProt

complete

GO:0016192

vesicle-mediated transport

PMID:10798391[12]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0017157

regulation of exocytosis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028669

P

Seeded From UniProt

complete

GO:0031201

SNARE complex

PMID:20688915[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031201

SNARE complex

PMID:21316453[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0031629

synaptic vesicle fusion to presynaptic membrane

PMID:17341138[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031629

synaptic vesicle fusion to presynaptic membrane

PMID:21316453[10]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0043195

terminal bouton

PMID:21316453[10]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0048278

vesicle docking

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000461349

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Wang, Z & Chapman, ER (2010) Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. J. Biol. Chem. 285 30759-66 PubMed GONUTS page
  2. Somma, MP et al. (2002) Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol. Biol. Cell 13 2448-60 PubMed GONUTS page
  3. Echard, A et al. (2004) Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14 1685-93 PubMed GONUTS page
  4. 4.0 4.1 Littleton, JT et al. (1999) Mechanisms of neurotransmitter release. Int. Rev. Neurobiol. 43 139-61 PubMed GONUTS page
  5. 5.0 5.1 5.2 Littleton, JT (2000) A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila. J. Cell Biol. 150 F77-82 PubMed GONUTS page
  6. Xu, H et al. (2002) Drosophila syntaxin 16 is a Q-SNARE implicated in Golgi dynamics. J. Cell. Sci. 115 4447-55 PubMed GONUTS page
  7. Giot, L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302 1727-36 PubMed GONUTS page
  8. Pacifico, S et al. (2006) A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics 7 195 PubMed GONUTS page
  9. Schwartz, AS et al. (2009) Cost-effective strategies for completing the interactome. Nat. Methods 6 55-61 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 Yu, W et al. (2011) Activity-dependent interactions of NSF and SNAP at living synapses. Mol. Cell. Neurosci. 47 19-27 PubMed GONUTS page
  11. Khanna, MR et al. (2010) Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. BMC Genomics 11 302 PubMed GONUTS page
  12. 12.0 12.1 Lloyd, TE et al. (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26 45-50 PubMed GONUTS page
  13. 13.0 13.1 Schulze, KL et al. (1995) Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell 80 311-20 PubMed GONUTS page
  14. Ruden, DM et al. (2000) Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev. Biol. 218 314-25 PubMed GONUTS page
  15. Tepass, U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 747-84 PubMed GONUTS page
  16. Mazumdar, A & Mazumdar, M (2002) How one becomes many: blastoderm cellularization in Drosophila melanogaster. Bioessays 24 1012-22 PubMed GONUTS page
  17. Pallavi, SK et al. (2006) Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev. Biol. 296 340-52 PubMed GONUTS page
  18. Lagow, RD et al. (2007) Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion. PLoS Biol. 5 e72 PubMed GONUTS page