DROME:STX1A

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Syx1A (synonyms: syx-1A)
Protein Name(s)	Syntaxin-1A dSynt1
External Links
UniProt	Q24547
EMBL	L37732 AE014297 AY061472
PIR	A55673
RefSeq	NP_524475.1
UniGene	Dm.2366
ProteinModelPortal	Q24547
SMR	Q24547
BioGrid	67788
DIP	DIP-19389N
IntAct	Q24547
MINT	MINT-957003
PaxDb	Q24547
PRIDE	Q24547
EnsemblMetazoa	FBtr0084588
GeneID	42854
KEGG	dme:Dmel_CG31136
CTD	42854
FlyBase	FBgn0013343
eggNOG	COG5074
GeneTree	ENSGT00760000119200
InParanoid	Q24547
KO	K04560
OrthoDB	EOG7X9G7R
PhylomeDB	Q24547
GenomeRNAi	42854
NextBio	830935
Proteomes	UP000000803
Bgee	Q24547
GO	GO:0016021 GO:0005886 GO:0031201 GO:0008021 GO:0043195 GO:0005484 GO:0000149 GO:0007349 GO:0007482 GO:0006886 GO:0000281 GO:0007274 GO:0007269 GO:0017157 GO:0007317 GO:0016081 GO:0031629 GO:0006906 GO:0016192
InterPro	IPR028669 IPR006012 IPR006011 IPR010989 IPR000727
PANTHER	PTHR19957:SF84
Pfam	PF05739 PF00804
SMART	SM00503 SM00397
SUPFAM	SSF47661
PROSITE	PS00914 PS50192

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0048787	presynaptic active zone membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000461527 RGD:3784 RGD:69430	C	Seeded From UniProt	complete
involved_in	GO:0048278	vesicle docking	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000461349 SGD:S000005632	P	Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103077 PANTHER:PTN000461527 RGD:3784 RGD:69430	C	Seeded From UniProt	complete
involved_in	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013343 MGI:MGI:1930705 PANTHER:PTN000461527 RGD:69430	P	Seeded From UniProt	complete
part_of	GO:0031201	SNARE complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013343 FB:FBgn0035540 MGI:MGI:103077 MGI:MGI:893577 PANTHER:PTN000461349 RGD:61917 RGD:619747 RGD:621005 RGD:621019 RGD:68426 SGD:S000002876 SGD:S000003180 SGD:S000004016 SGD:S000005378 SGD:S000005632 SGD:S000006153 UniProtKB:O14662 UniProtKB:O43752 UniProtKB:P56962 UniProtKB:Q12846 UniProtKB:Q16623 UniProtKB:Q86Y82 dictyBase:DDB_G0275429	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031106 PANTHER:PTN000461349 RGD:61915 SGD:S000004016	C	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000461349 TAIR:locus:2025620	C	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013343 MGI:MGI:103077 MGI:MGI:109355 PANTHER:PTN000461527	C	Seeded From UniProt	complete
involved_in	GO:0006906	vesicle fusion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013343 MGI:MGI:103077 PANTHER:PTN000461349 RGD:61917 RGD:619747 SGD:S000002876 SGD:S000003180 SGD:S000004016 SGD:S000005378 SGD:S000005632 SGD:S000006153 UniProtKB:O43752 dictyBase:DDB_G0275429 dictyBase:DDB_G0287733	P	Seeded From UniProt	complete
involved_in	GO:0006887	exocytosis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103077 PANTHER:PTN000461524	P	Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000461349 UniProtKB:Q946Y7	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109355 MGI:MGI:1930705 MGI:MGI:893577 PANTHER:PTN000461524 PomBase:SPCC825.03c RGD:621005 RGD:621019 RGD:69430 SGD:S000004795 SGD:S000006153 TAIR:locus:2025620 TAIR:locus:2079449 TAIR:locus:2079894 TAIR:locus:2081476 TAIR:locus:2197749 UniProtKB:O96189 UniProtKB:P32856 UniProtKB:Q12846 UniProtKB:Q13277 UniProtKB:Q16623 UniProtKB:Q8VZU2 WB:WBGene00006371	C	Seeded From UniProt	complete
enables	GO:0005484	SNAP receptor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011708 FB:FBgn0013343 FB:FBgn0031106 FB:FBgn0035540 PANTHER:PTN000461349 RGD:619747 RGD:621005 RGD:621019 SGD:S000000012 SGD:S000002876 SGD:S000003180 SGD:S000004016 SGD:S000004795 SGD:S000005378 SGD:S000005562 SGD:S000005632 SGD:S000006153 TAIR:locus:2148960 UniProtKB:O14662 UniProtKB:P56962 UniProtKB:Q13190	F	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0013343 FB:FBgn0035540 MGI:MGI:109355 MGI:MGI:893577 PANTHER:PTN000461349 RGD:2558 RGD:619747 RGD:621019 RGD:69430 RGD:708499 UniProtKB:O15400 UniProtKB:P56962	F	Seeded From UniProt	complete
involved_in	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	PMID:21316453^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031201	SNARE complex	PMID:21316453^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	PMID:21316453^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007274	neuromuscular synaptic transmission	PMID:21316453^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005484	SNAP receptor activity	PMID:20688915^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006906	vesicle fusion	PMID:20688915^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031201	SNARE complex	PMID:20688915^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	PMID:20688915^[3]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0011288,FB:FBgn0013342	F	Seeded From UniProt	complete
involved_in	GO:0031629	synaptic vesicle fusion to presynaptic active zone membrane	PMID:17341138^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007482	haltere development	PMID:16815386^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003944	P	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:15380073^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:12134082^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10908590^[8]	ECO:0000250	sequence similarity evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
enables	GO:0005484	SNAP receptor activity	PMID:10908590^[8]	ECO:0000250	sequence similarity evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
involved_in	GO:0016081	synaptic vesicle docking	PMID:10908590^[8]	ECO:0000250	sequence similarity evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0016192	vesicle-mediated transport	PMID:10798391^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	PMID:10798391^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007317	regulation of pole plasm oskar mRNA localization	PMID:10656772^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10218158^[11]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005484	SNAP receptor activity	PMID:10218158^[11]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007269	neurotransmitter secretion	PMID:7834751^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	PMID:7834751^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028669	F	Seeded From UniProt	complete
enables	GO:0005484	SNAP receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006012	F	Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006012	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006011 InterPro:IPR006012 InterPro:IPR010989	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028669	C	Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010989 InterPro:IPR028669	P	Seeded From UniProt	complete
involved_in	GO:0017157	regulation of exocytosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028669	P	Seeded From UniProt	complete
involved_in	GO:0007349	cellularization	PMID:12386932^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C	Seeded From UniProt	complete
involved_in	GO:0006836	neurotransmitter transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0532	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C	Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0260	C	Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0157	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Yu, W et al. (2011) Activity-dependent interactions of NSF and SNAP at living synapses. Mol. Cell. Neurosci. 47 19-27 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Wang, Z & Chapman, ER (2010) Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. J. Biol. Chem. 285 30759-66 PubMed GONUTS page
↑ Lagow, RD et al. (2007) Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion. PLoS Biol. 5 e72 PubMed GONUTS page
↑ Pallavi, SK et al. (2006) Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev. Biol. 296 340-52 PubMed GONUTS page
↑ Echard, A et al. (2004) Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14 1685-93 PubMed GONUTS page
↑ Somma, MP et al. (2002) Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol. Biol. Cell 13 2448-60 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Littleton, JT (2000) A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila. J. Cell Biol. 150 F77-82 PubMed GONUTS page
↑ ^9.0 ^9.1 Lloyd, TE et al. (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26 45-50 PubMed GONUTS page
↑ Ruden, DM et al. (2000) Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev. Biol. 218 314-25 PubMed GONUTS page
↑ ^11.0 ^11.1 Littleton, JT et al. (1999) Mechanisms of neurotransmitter release. Int. Rev. Neurobiol. 43 139-61 PubMed GONUTS page
↑ ^12.0 ^12.1 Schulze, KL et al. (1995) Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell 80 311-20 PubMed GONUTS page
↑ Mazumdar, A & Mazumdar, M (2002) How one becomes many: blastoderm cellularization in Drosophila melanogaster. Bioessays 24 1012-22 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21316453-2] 2.0 ^2.1 ^2.2 ^2.3 Yu, W et al. (2011) Activity-dependent interactions of NSF and SNAP at living synapses. Mol. Cell. Neurosci. 47 19-27 PubMed GONUTS page

[PMID:20688915-3] 3.0 ^3.1 ^3.2 ^3.3 Wang, Z & Chapman, ER (2010) Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. J. Biol. Chem. 285 30759-66 PubMed GONUTS page

[PMID:17341138-4] Lagow, RD et al. (2007) Modification of a hydrophobic layer by a point mutation in syntaxin 1A regulates the rate of synaptic vesicle fusion. PLoS Biol. 5 e72 PubMed GONUTS page

[PMID:16815386-5] Pallavi, SK et al. (2006) Negative regulation of Egfr/Ras pathway by Ultrabithorax during haltere development in Drosophila. Dev. Biol. 296 340-52 PubMed GONUTS page

[PMID:15380073-6] Echard, A et al. (2004) Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14 1685-93 PubMed GONUTS page

[PMID:12134082-7] Somma, MP et al. (2002) Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol. Biol. Cell 13 2448-60 PubMed GONUTS page

[PMID:10908590-8] 8.0 ^8.1 ^8.2 Littleton, JT (2000) A genomic analysis of membrane trafficking and neurotransmitter release in Drosophila. J. Cell Biol. 150 F77-82 PubMed GONUTS page

[PMID:10798391-9] 9.0 ^9.1 Lloyd, TE et al. (2000) A genome-wide search for synaptic vesicle cycle proteins in Drosophila. Neuron 26 45-50 PubMed GONUTS page

[PMID:10656772-10] Ruden, DM et al. (2000) Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev. Biol. 218 314-25 PubMed GONUTS page

[PMID:10218158-11] 11.0 ^11.1 Littleton, JT et al. (1999) Mechanisms of neurotransmitter release. Int. Rev. Neurobiol. 43 139-61 PubMed GONUTS page

[PMID:7834751-12] 12.0 ^12.1 Schulze, KL et al. (1995) Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell 80 311-20 PubMed GONUTS page

[PMID:12386932-13] Mazumdar, A & Mazumdar, M (2002) How one becomes many: blastoderm cellularization in Drosophila melanogaster. Bioessays 24 1012-22 PubMed GONUTS page

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DROME:STX1A

Contents

Annotations

Notes

References

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