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DROME:SPT6H

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Spt6
Protein Name(s) Transcription elongation factor SPT6
External Links
UniProt Q9W420
EMBL AF104400
AF104401
AE014298
AY052030
RefSeq NP_001284936.1
NP_651962.2
ProteinModelPortal Q9W420
SMR Q9W420
BioGrid 68765
IntAct Q9W420
STRING 7227.FBpp0070861
PaxDb Q9W420
PRIDE Q9W420
EnsemblMetazoa FBtr0070896
GeneID 44000
KEGG dme:Dmel_CG12225
CTD 44000
FlyBase FBgn0028982
eggNOG COG2183
GeneTree ENSGT00510000047446
InParanoid Q9W420
KO K11292
OMA RRSIFEM
OrthoDB EOG7DFXBC
PhylomeDB Q9W420
GenomeRNAi 44000
NextBio 836551
PRO PR:Q9W420
Proteomes UP000000803
Bgee Q9W420
GO GO:0035363
GO:0005634
GO:0005705
GO:0005703
GO:0008023
GO:0035327
GO:0003682
GO:0003677
GO:0016788
GO:0003723
GO:0032968
GO:0002805
GO:0006366
Gene3D 1.10.150.310
1.10.3500.10
2.40.50.140
3.30.420.140
InterPro IPR012340
IPR003029
IPR012337
IPR010994
IPR022967
IPR000980
IPR028083
IPR027999
IPR028088
IPR028231
IPR023323
IPR023097
IPR017072
IPR006641
PANTHER PTHR10145:SF6
Pfam PF14878
PF14641
PF00575
PF14633
PF14632
PF14639
PIRSF PIRSF036947
SMART SM00316
SM00252
SM00732
SUPFAM SSF47781
SSF50249
SSF53098
SSF55550
PROSITE PS50126

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000993

RNA polymerase II complex binding

PMID:12934007[1]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P04052)

Seeded From UniProt

complete

part_of

GO:0008023

transcription elongation factor complex

PMID:12934007[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9V460

C

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

PMID:11040216[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005705

polytene chromosome interband

PMID:11040216[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005703

polytene chromosome puff

PMID:11040217[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005703

polytene chromosome puff

PMID:12934007[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005703

polytene chromosome puff

PMID:11040216[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070827

chromatin maintenance

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015765
PomBase:SPAC1F7.01c
SGD:S000003348

P

Seeded From UniProt

complete

involved_in

GO:0050684

regulation of mRNA processing

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107726
PANTHER:PTN000015765

P

Seeded From UniProt

complete

involved_in

GO:0042789

mRNA transcription by RNA polymerase II

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015765
PomBase:SPAC1F7.01c

P

Seeded From UniProt

complete

enables

GO:0042393

histone binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015765
SGD:S000003348
UniProtKB:Q7KZ85

F

Seeded From UniProt

complete

part_of

GO:0035327

transcriptionally active chromatin

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028982
PANTHER:PTN000015765
SGD:S000003348

C

Seeded From UniProt

complete

involved_in

GO:0034728

nucleosome organization

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015765
SGD:S000003348

P

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028982
MGI:MGI:107726
PANTHER:PTN000015765
SGD:S000003348
UniProtKB:Q7KZ85

P

Seeded From UniProt

complete

enables

GO:0031491

nucleosome binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015765
SGD:S000003348

F

Seeded From UniProt

complete

part_of

GO:0008023

transcription elongation factor complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028982
PANTHER:PTN000015765

C

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

CGD:CAL0000194756
PANTHER:PTN000015765

P

Seeded From UniProt

complete

involved_in

GO:0030707

ovarian follicle cell development

PMID:26205122[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:19279664[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035363

histone locus body

PMID:21576393[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006963

positive regulation of antibacterial peptide biosynthetic process

PMID:20421637[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:17174895[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17174895[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:17174895[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0035327

transcriptionally active chromatin

PMID:12490954[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003029

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028088

F

Seeded From UniProt

complete

involved_in

GO:0006139

nucleobase-containing compound metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006641

P

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017072

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Saunders, A et al. (2003) Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science 301 1094-6 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Kaplan, CD et al. (2000) Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster. Genes Dev. 14 2623-34 PubMed GONUTS page
  3. ↑ Andrulis, ED et al. (2000) High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation. Genes Dev. 14 2635-49 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page
  6. ↑ Ardehali, MB et al. (2009) Spt6 enhances the elongation rate of RNA polymerase II in vivo. EMBO J. 28 1067-77 PubMed GONUTS page
  7. ↑ White, AE et al. (2011) Drosophila histone locus bodies form by hierarchical recruitment of components. J. Cell Biol. 193 677-94 PubMed GONUTS page
  8. ↑ Valanne, S et al. (2010) Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. J. Immunol. 184 6188-98 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Petruk, S et al. (2006) Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference. Cell 127 1209-21 PubMed GONUTS page
  10. ↑ Andrulis, ED et al. () The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Nature 420 837-41 PubMed GONUTS page
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