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DROME:SPT6H

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Spt6
Protein Name(s) Transcription elongation factor SPT6
External Links
UniProt Q9W420
EMBL AF104400
AF104401
AE014298
AY052030
RefSeq NP_001284936.1
NP_651962.2
ProteinModelPortal Q9W420
SMR Q9W420
BioGrid 68765
IntAct Q9W420
STRING 7227.FBpp0070861
PaxDb Q9W420
PRIDE Q9W420
EnsemblMetazoa FBtr0070896
GeneID 44000
KEGG dme:Dmel_CG12225
CTD 44000
FlyBase FBgn0028982
eggNOG COG2183
GeneTree ENSGT00510000047446
InParanoid Q9W420
KO K11292
OMA RRSIFEM
OrthoDB EOG7DFXBC
PhylomeDB Q9W420
GenomeRNAi 44000
NextBio 836551
PRO PR:Q9W420
Proteomes UP000000803
Bgee Q9W420
GO GO:0035363
GO:0005634
GO:0005705
GO:0005703
GO:0008023
GO:0035327
GO:0003682
GO:0003677
GO:0016788
GO:0003723
GO:0032968
GO:0002805
GO:0006366
Gene3D 1.10.150.310
1.10.3500.10
2.40.50.140
3.30.420.140
InterPro IPR012340
IPR003029
IPR012337
IPR010994
IPR022967
IPR000980
IPR028083
IPR027999
IPR028088
IPR028231
IPR023323
IPR023097
IPR017072
IPR006641
PANTHER PTHR10145:SF6
Pfam PF14878
PF14641
PF00575
PF14633
PF14632
PF14639
PIRSF PIRSF036947
SMART SM00316
SM00252
SM00732
SUPFAM SSF47781
SSF50249
SSF53098
SSF55550
PROSITE PS50126

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002805

regulation of antimicrobial peptide biosynthetic process

PMID:20421637[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0003723

RNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003029

F

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0005703

polytene chromosome puff

PMID:11040216[2]

IDA: Inferred from Direct Assay

C

complete

GO:0002805

regulation of antimicrobial peptide biosynthetic process

PMID:20421637[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0005703

polytene chromosome puff

PMID:11040217[3]

IDA: Inferred from Direct Assay

C

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003029
InterPro:IPR012337

F

Seeded From UniProt

complete

GO:0005703

polytene chromosome puff

PMID:12934007[4]

IDA: Inferred from Direct Assay

C

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028088

F

Seeded From UniProt

complete

GO:0005705

polytene chromosome interband

PMID:11040216[2]

IDA: Inferred from Direct Assay

C

complete

GO:0003682

chromatin binding

PMID:17174895[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0006139

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006641

P

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0005634

nucleus

PMID:17174895[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0005703

polytene chromosome puff

PMID:11040216[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017072

P

complete

GO:0005703

polytene chromosome puff

PMID:11040217[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006366

transcription from RNA polymerase II promoter

PMID:11040216[2]

IEP: Inferred from Expression Pattern

P

complete

GO:0005703

polytene chromosome puff

PMID:12934007[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0008023

transcription elongation factor complex

PMID:12934007[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9V460

C

complete

GO:0005705

polytene chromosome interband

PMID:11040216[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016788

hydrolase activity, acting on ester bonds

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006641

F

complete

GO:0006139

nucleobase-containing compound metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006641

P

Seeded From UniProt

complete

GO:0032784

regulation of transcription elongation, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017072

P

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0035327

transcriptionally active chromatin

PMID:12490954[6]

IDA: Inferred from Direct Assay

C

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0035363

histone locus body

PMID:21576393[7]

IDA: Inferred from Direct Assay

C

complete

GO:0006357

regulation of transcription from RNA polymerase II promoter

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017072

P

Seeded From UniProt

complete

colocalizes_with

GO:0000176

nuclear exosome (RNase complex)

PMID:12490954[6]

IDA: Inferred from Direct Assay

C

complete

GO:0006366

transcription from RNA polymerase II promoter

PMID:11040216[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

colocalizes_with

GO:0035101

FACT complex

PMID:12934007[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q05344

C

complete

GO:0008023

transcription elongation factor complex

PMID:12934007[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9V460

C

Seeded From UniProt

complete

GO:0032784

regulation of DNA-templated transcription, elongation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR017072

P

Seeded From UniProt

complete

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:17174895[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:19279664[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035327

transcriptionally active chromatin

PMID:12490954[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035363

histone locus body

PMID:21576393[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

colocalizes_with

GO:0000176

nuclear exosome (RNase complex)

PMID:12490954[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

colocalizes_with

GO:0035101

FACT complex

PMID:12934007[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q05344

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Valanne, S et al. (2010) Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. J. Immunol. 184 6188-98 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Kaplan, CD et al. (2000) Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster. Genes Dev. 14 2623-34 PubMed GONUTS page
  3. 3.0 3.1 Andrulis, ED et al. (2000) High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation. Genes Dev. 14 2635-49 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Saunders, A et al. (2003) Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science 301 1094-6 PubMed GONUTS page
  5. 5.0 5.1 5.2 Petruk, S et al. (2006) Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference. Cell 127 1209-21 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Andrulis, ED et al. () The RNA processing exosome is linked to elongating RNA polymerase II in Drosophila. Nature 420 837-41 PubMed GONUTS page
  7. 7.0 7.1 White, AE et al. (2011) Drosophila histone locus bodies form by hierarchical recruitment of components. J. Cell Biol. 193 677-94 PubMed GONUTS page
  8. Ardehali, MB et al. (2009) Spt6 enhances the elongation rate of RNA polymerase II in vivo. EMBO J. 28 1067-77 PubMed GONUTS page