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DROME:SPT4H

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) spt4
Protein Name(s) Transcription elongation factor SPT4

DRB sensitivity-inducing factor small subunit DSIF small subunit dSpt4

External Links
UniProt Q9TVQ5
EMBL AF108353
AF109133
AE013599
AY075424
RefSeq NP_610802.1
UniGene Dm.19918
ProteinModelPortal Q9TVQ5
SMR Q9TVQ5
BioGrid 62161
MINT MINT-813567
STRING 7227.FBpp0086953
PaxDb Q9TVQ5
PRIDE Q9TVQ5
EnsemblMetazoa FBtr0087840
GeneID 36387
KEGG dme:Dmel_CG12372
UCSC CG12372-RA
CTD 36387
FlyBase FBgn0028683
eggNOG COG5204
GeneTree ENSGT00390000018559
InParanoid Q9TVQ5
KO K15171
OMA ACMLCGI
OrthoDB EOG7RFTK7
PhylomeDB Q9TVQ5
Reactome REACT_217308
REACT_221895
REACT_226178
GenomeRNAi 36387
NextBio 798282
PRO PR:Q9TVQ5
Proteomes UP000000803
Bgee Q9TVQ5
GO GO:0005634
GO:0005705
GO:0005703
GO:0008023
GO:0046982
GO:0008270
GO:0032785
GO:0000122
GO:0032786
GO:0045944
GO:0006368
InterPro IPR029040
IPR009287
IPR016046
IPR022800
PANTHER PTHR12882
Pfam PF06093
PIRSF PIRSF025023
SUPFAM SSF63393

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:12782658[1]

ECO:0000314

P

Fig. 1 DSIF (formed from DROME:SPT4H and DROME:SPT5H) is shown to cause promoter proximal pausing by monitoring the reactivity of the transcribed DNA to permanganate. Immunodepletion of DSIF inhibits promoter proximal pausing, and restoring DSIF restores promoter proximal pausing.

complete

Contributes to

GO:0008148

negative transcription elongation factor activity

PMID:12782658[1]

ECO:0000314

F

Fig. 1 DSIF (formed from DROME:SPT4H and DROME:SPT5H) is shown to cause promoter proximal pausing by monitoring the reactivity of the transcribed DNA to permanganate. Immunodepletion of DSIF inhibits promoter proximal pausing, and restoring DSIF restores promoter proximal pausing.

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P63272

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P63272

P

Seeded From UniProt

complete

involved_in

GO:0032786

positive regulation of DNA-templated transcription, elongation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P63272

P

Seeded From UniProt

complete

involved_in

GO:0032785

negative regulation of DNA-templated transcription, elongation

PMID:12782658[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032785

negative regulation of DNA-templated transcription, elongation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P63272

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

PMID:12782658[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P63272

P

Seeded From UniProt

complete

part_of

GO:0005705

polytene chromosome interband

PMID:12782658[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005703

polytene chromosome puff

PMID:12782658[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P63272

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:12782658[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P63272

P

Seeded From UniProt

complete

part_of

GO:0032044

DSIF complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028683
PANTHER:PTN000306261
PomBase:SPBC21C3.16c
SGD:S000003295
UniProtKB:P63272

C

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000306261
SGD:S000003295

P

Seeded From UniProt

complete

enables

GO:0003727

single-stranded RNA binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000306261
SGD:S000003295

F

Seeded From UniProt

complete

enables

GO:0000993

RNA polymerase II complex binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0028683
PANTHER:PTN000306261
SGD:S000003295

F

Seeded From UniProt

complete

part_of

GO:0008023

transcription elongation factor complex

PMID:15056674[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15056674[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032044

DSIF complex

PMID:28213523[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0000993

RNA polymerase II complex binding

PMID:28213523[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:28213523[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009287

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009287

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009287

F

Seeded From UniProt

complete

involved_in

GO:0032786

positive regulation of DNA-templated transcription, elongation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR009287

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Wu, CH et al. (2003) NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev. 17 1402-14 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Zhang, Z et al. (2004) Analysis of polymerase II elongation complexes by native gel electrophoresis. Evidence for a novel carboxyl-terminal domain-mediated termination mechanism. J. Biol. Chem. 279 23223-8 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Qiu, Y & Gilmour, DS (2017) Identification of Regions in the Spt5 Subunit of DRB Sensitivity-inducing Factor (DSIF) That Are Involved in Promoter-proximal Pausing. J. Biol. Chem. 292 5555-5570 PubMed GONUTS page
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