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DROME:RUMI
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | rumi (ECO:0000312 with FlyBase:FBgn0086253) | |
| Protein Name(s) | O-glucosyltransferase rumi | |
| External Links | ||
| UniProt | Q8T045 | |
| EMBL | AE014297 AY069564 | |
| RefSeq | NP_651095.1 | |
| UniGene | Dm.1286 | |
| BioGrid | 77376 | |
| MINT | MINT-1699273 | |
| STRING | 7227.FBpp0083713 | |
| CAZy | GT90 | |
| PaxDb | Q8T045 | |
| PRIDE | Q8T045 | |
| EnsemblMetazoa | FBtr0084320 | |
| GeneID | 326122 | |
| KEGG | dme:Dmel_CG31152 | |
| UCSC | CG31152-RA | |
| CTD | 326122 | |
| FlyBase | FBgn0086253 | |
| eggNOG | NOG248922 | |
| GeneTree | ENSGT00530000063132 | |
| InParanoid | Q8T045 | |
| KO | K13667 | |
| OMA | PARCEGI | |
| OrthoDB | EOG7R831J | |
| PhylomeDB | Q8T045 | |
| Reactome | REACT_180761 | |
| UniPathway | UPA00378 | |
| GenomeRNAi | 326122 | |
| NextBio | 847167 | |
| PRO | PR:Q8T045 | |
| Proteomes | UP000000803 | |
| Bgee | Q8T045 | |
| GO | GO:0012505 GO:0005788 GO:0046527 GO:0007030 GO:0045746 GO:0007219 GO:0045747 GO:0033577 GO:2000035 | |
| InterPro | IPR006598 | |
| Pfam | PF05686 | |
| SMART | SM00672 | |
| PROSITE | PS00014 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0042052 |
rhabdomere development |
ECO:0000316 |
|
P |
Figure 4 |
complete | ||||
|
enables |
GO:0035251 |
UDP-glucosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018242 |
protein O-linked glycosylation via serine |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045747 |
positive regulation of Notch signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060537 |
muscle tissue development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042052 |
rhabdomere development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046527 |
glucosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045746 |
negative regulation of Notch signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0033577 |
protein glycosylation in endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046527 |
glucosyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0086253 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045747 |
positive regulation of Notch signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0086253 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035252 |
UDP-xylosyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444232 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0035251 |
UDP-glucosyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444232 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006493 |
protein O-linked glycosylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2444232 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0086253 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042052 |
rhabdomere development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0012505 |
endomembrane system |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000035 |
regulation of stem cell division |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045747 |
positive regulation of Notch signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0004647 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007030 |
Golgi organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045747 |
positive regulation of Notch signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0004647 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045747 |
positive regulation of Notch signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00378 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Haltom, AR et al. (2014) The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet. 10 e1004795 PubMed GONUTS page
- ↑ 2.0 2.1 Yu, H et al. (2016) Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations. Nat. Chem. Biol. 12 735-40 PubMed GONUTS page
- ↑ 3.0 3.1 Servián-Morilla, E et al. (2016) A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss. EMBO Mol Med 8 1289-1309 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Acar, M et al. (2008) Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell 132 247-58 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
- ↑ Perdigoto, CN et al. (2011) Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. Development 138 4585-95 PubMed GONUTS page
- ↑ Leonardi, J et al. (2011) Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development 138 3569-78 PubMed GONUTS page
- ↑ Kondylis, V et al. (2011) Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. PLoS ONE 6 e17173 PubMed GONUTS page
- ↑ Ishio, A et al. (2015) O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. J. Biol. Chem. 290 505-19 PubMed GONUTS page
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