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DROME:RUMI

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) rumi (ECO:0000312 with FlyBase:FBgn0086253)
Protein Name(s) O-glucosyltransferase rumi
External Links
UniProt Q8T045
EMBL AE014297
AY069564
RefSeq NP_651095.1
UniGene Dm.1286
BioGrid 77376
MINT MINT-1699273
STRING 7227.FBpp0083713
CAZy GT90
PaxDb Q8T045
PRIDE Q8T045
EnsemblMetazoa FBtr0084320
GeneID 326122
KEGG dme:Dmel_CG31152
UCSC CG31152-RA
CTD 326122
FlyBase FBgn0086253
eggNOG NOG248922
GeneTree ENSGT00530000063132
InParanoid Q8T045
KO K13667
OMA PARCEGI
OrthoDB EOG7R831J
PhylomeDB Q8T045
Reactome REACT_180761
UniPathway UPA00378
GenomeRNAi 326122
NextBio 847167
PRO PR:Q8T045
Proteomes UP000000803
Bgee Q8T045
GO GO:0012505
GO:0005788
GO:0046527
GO:0007030
GO:0045746
GO:0007219
GO:0045747
GO:0033577
GO:2000035
InterPro IPR006598
Pfam PF05686
SMART SM00672
PROSITE PS00014

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005783

endoplasmic reticulum

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0256

C

complete

GO:0005788

endoplasmic reticulum lumen

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0096

C

complete

GO:0005788

endoplasmic reticulum lumen

PMID:18243100[1]

IDA: Inferred from Direct Assay

C

complete

GO:0007030

Golgi organization

PMID:21383842[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0042052

rhabdomere development

PMID:25412384[3]

IGI: Inferred from Genetic Interaction

UniProtKB:A0A1F4


P

Figure 4

complete
CACAO 10385

GO:0007219

Notch signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0914

P

complete

GO:0007219

Notch signaling pathway

PMID:25412384[3]

IGI: Inferred from Genetic Interaction

UniProtKB:Q8T045


P

complete
CACAO 10386

GO:0007219

Notch signaling pathway

PMID:18243100[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0004647

P

complete

GO:0005783

endoplasmic reticulum

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

GO:0008466

glycogenin glucosyltransferase activity

PMID:18243100[1]

IDA: Inferred from Direct Assay

F

complete

GO:0005788

endoplasmic reticulum lumen

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0096

C

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

complete

GO:0005788

endoplasmic reticulum lumen

PMID:18243100[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0328

F

complete

GO:0006486

protein glycosylation

GO_REF:0000041

IEA: Inferred from Electronic Annotation

UniPathway:UPA00378

P

Seeded From UniProt

complete

GO:0007030

Golgi organization

PMID:21383842[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0033577

protein glycosylation in endoplasmic reticulum

PMID:18243100[1]

IDA: Inferred from Direct Assay

P

complete

GO:0007219

Notch signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

GO:0045746

negative regulation of Notch signaling pathway

PMID:18243100[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007219

Notch signaling pathway

PMID:18243100[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0004647

P

Seeded From UniProt

complete

GO:0046527

glucosyltransferase activity

PMID:18243100[1]

IDA: Inferred from Direct Assay

F

complete

GO:0012505

endomembrane system

PMID:19317464[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

GO:0033577

protein glycosylation in endoplasmic reticulum

PMID:18243100[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042052

rhabdomere development

PMID:25412384[3]

IGI: Inferred from Genetic Interaction

UniProtKB:A0A1F4

P

Seeded From UniProt

complete

GO:0042052

rhabdomere development

PMID:25412384[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045746

negative regulation of Notch signaling pathway

PMID:18243100[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045747

positive regulation of Notch signaling pathway

PMID:21771811[5]

IGI: Inferred from Genetic Interaction

FB:FBgn0004647

P

Seeded From UniProt

complete

GO:0046527

glucosyltransferase activity

PMID:18243100[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:2000035

regulation of stem cell division

PMID:21965616[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Acar, M et al. (2008) Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell 132 247-58 PubMed GONUTS page
  2. 2.0 2.1 Kondylis, V et al. (2011) Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. PLoS ONE 6 e17173 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Haltom, AR et al. (2014) The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet. 10 e1004795 PubMed GONUTS page
  4. Tan, DJ et al. (2009) Mapping organelle proteins and protein complexes in Drosophila melanogaster. J. Proteome Res. 8 2667-78 PubMed GONUTS page
  5. Leonardi, J et al. (2011) Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development 138 3569-78 PubMed GONUTS page
  6. Perdigoto, CN et al. (2011) Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine. Development 138 4585-95 PubMed GONUTS page