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DROME:RAD54
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | No Information Provided. (synonyms: RAD54 (ECO:0000312 with EMBL:CAA71278.1)) | |
| Protein Name(s) | DNA repair and recombination protein RAD54-like (ECO:0000303 with PMID:9315669[1])
DmRAD54 (ECO:0000303 with PMID:9315669[1]) Protein okra (ECO:0000303 with PMID:9732269[2]) RAD54 DNA repair protein (ECO:0000312 with EMBL:AAC26857.1) | |
| External Links | ||
| UniProt | O76460 | |
| EMBL | Y10229 AF069779 AF069780 AE014134 AY069599 FJ219215 FJ219218 FJ219219 FJ219220 FJ219221 FJ219222 FJ219223 FJ219224 FJ219225 FJ219226 FJ219227 FJ219228 FJ219229 FJ219230 FJ219231 FJ219232 FJ219233 FJ219234 FJ219235 FJ219236 FJ219237 FJ219238 FJ219239 FJ219240 FJ219241 FJ219242 FJ219243 FJ219244 FJ219245 FJ219246 FJ219247 | |
| RefSeq | NP_476661.1 | |
| UniGene | Dm.19774 | |
| ProteinModelPortal | O76460 | |
| SMR | O76460 | |
| BioGrid | 59726 | |
| IntAct | O76460 | |
| MINT | MINT-807919 | |
| STRING | 7227.FBpp0077357 | |
| PaxDb | O76460 | |
| PRIDE | O76460 | |
| EnsemblMetazoa | FBtr0077673 | |
| GeneID | 33507 | |
| KEGG | dme:Dmel_CG3736 | |
| UCSC | CG3736-RA | |
| CTD | 33507 | |
| FlyBase | FBgn0002989 | |
| eggNOG | COG0553 | |
| GeneTree | ENSGT00550000074619 | |
| InParanoid | O76460 | |
| KO | K10875 | |
| OMA | VTRPVII | |
| OrthoDB | EOG7DJSKN | |
| PhylomeDB | O76460 | |
| GenomeRNAi | 33507 | |
| NextBio | 783944 | |
| PRO | PR:O76460 | |
| Proteomes | UP000000803 | |
| Bgee | O76460 | |
| GO | GO:0005634 GO:0005524 GO:0003677 GO:0004386 GO:0006338 GO:0030261 GO:0006310 GO:0006281 GO:0043150 GO:0046843 GO:0006302 GO:0000724 GO:0045003 GO:0008298 GO:0000711 GO:0007067 GO:0048477 GO:0007131 GO:0006417 GO:0010212 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR014001 IPR001650 IPR027417 IPR013967 IPR000330 | |
| Pfam | PF00271 PF08658 PF00176 | |
| SMART | SM00487 SM00490 | |
| SUPFAM | SSF52540 | |
| PROSITE | PS51192 PS51194 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0071481 |
cellular response to X-ray |
ECO:0000315 |
P |
Table 1 |
complete | |||||
|
involved_in |
GO:0043150 |
DNA synthesis involved in double-strand break repair via homologous recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010212 |
response to ionizing radiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006338 |
chromatin remodeling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003674 |
molecular_function |
ECO:0000307 |
no biological data found used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000711 |
meiotic DNA repair synthesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048477 |
oogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0039044 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045003 |
double-strand break repair via synthesis-dependent strand annealing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010212 |
response to ionizing radiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006302 |
double-strand break repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0048477 |
oogenesis |
ECO:0007001 |
high throughput mutant phenotypic evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046843 |
dorsal appendage formation |
ECO:0007001 |
high throughput mutant phenotypic evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006302 |
double-strand break repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
part_of:(GO:0051598) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030716 |
oocyte fate determination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007131 |
reciprocal meiotic recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016817 |
hydrolase activity, acting on acid anhydrides |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006302 |
double-strand break repair |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048477 |
oogenesis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007131 |
reciprocal meiotic recombination |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030261 |
chromosome condensation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006417 |
regulation of translation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008298 |
intracellular mRNA localization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051321 |
meiotic cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Kooistra, R et al. (1997) The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Mol. Cell. Biol. 17 6097-104 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Ghabrial, A et al. (1998) okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Genes Dev. 12 2711-23 PubMed GONUTS page
- ↑ 3.0 3.1 Alexiadis, V et al. (2004) A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing. J. Biol. Chem. 279 27824-9 PubMed GONUTS page
- ↑ Lu, WJ et al. (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328 1278-81 PubMed GONUTS page
- ↑ Wei, DS & Rong, YS (2007) A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics 177 63-77 PubMed GONUTS page
- ↑ Gorski, MM et al. (2003) The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Genetics 165 1929-41 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 van Eeden, F & St Johnston, D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr. Opin. Genet. Dev. 9 396-404 PubMed GONUTS page
- ↑ 8.0 8.1 Schüpbach, T & Wieschaus, E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 1119-36 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Joyce, EF & McKim, KS (2009) Drosophila PCH2 is required for a pachytene checkpoint that monitors double-strand-break-independent events leading to meiotic crossover formation. Genetics 181 39-51 PubMed GONUTS page
- ↑ Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page
- ↑ Morris, J & Lehmann, R (1999) Drosophila oogenesis: versatile spn doctors. Curr. Biol. 9 R55-8 PubMed GONUTS page
- ↑ 12.0 12.1 Cooperstock, RL & Lipshitz, HD (1997) Control of mRNA stability and translation during Drosophila development. Semin. Cell Dev. Biol. 8 541-9 PubMed GONUTS page
c
d
- Diptera
- GO:0003677 ! DNA binding
- GO:0006974 ! DNA damage response
- GO:0006310 ! DNA recombination
- GO:0006281 ! DNA repair
- GO:0043150 ! DNA synthesis involved in double-strand break repair via homologous recombination
- GO:0046843 ! dorsal appendage formation
- GO:0006302 ! double-strand break repair
- GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing
- GO:0000724 ! double-strand break repair via homologous recombination
- Drosophila
- Drosophila melanogaster
- Drosophilidae
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