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DROME:RAD54

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided. (synonyms: RAD54 (ECO:0000312 with EMBL:CAA71278.1))
Protein Name(s) DNA repair and recombination protein RAD54-like (ECO:0000303 with PMID:9315669[1])

DmRAD54 (ECO:0000303 with PMID:9315669[1]) Protein okra (ECO:0000303 with PMID:9732269[2]) RAD54 DNA repair protein (ECO:0000312 with EMBL:AAC26857.1)

External Links
UniProt O76460
EMBL Y10229
AF069779
AF069780
AE014134
AY069599
FJ219215
FJ219218
FJ219219
FJ219220
FJ219221
FJ219222
FJ219223
FJ219224
FJ219225
FJ219226
FJ219227
FJ219228
FJ219229
FJ219230
FJ219231
FJ219232
FJ219233
FJ219234
FJ219235
FJ219236
FJ219237
FJ219238
FJ219239
FJ219240
FJ219241
FJ219242
FJ219243
FJ219244
FJ219245
FJ219246
FJ219247
RefSeq NP_476661.1
UniGene Dm.19774
ProteinModelPortal O76460
SMR O76460
BioGrid 59726
IntAct O76460
MINT MINT-807919
STRING 7227.FBpp0077357
PaxDb O76460
PRIDE O76460
EnsemblMetazoa FBtr0077673
GeneID 33507
KEGG dme:Dmel_CG3736
UCSC CG3736-RA
CTD 33507
FlyBase FBgn0002989
eggNOG COG0553
GeneTree ENSGT00550000074619
InParanoid O76460
KO K10875
OMA VTRPVII
OrthoDB EOG7DJSKN
PhylomeDB O76460
GenomeRNAi 33507
NextBio 783944
PRO PR:O76460
Proteomes UP000000803
Bgee O76460
GO GO:0005634
GO:0005524
GO:0003677
GO:0004386
GO:0006338
GO:0030261
GO:0006310
GO:0006281
GO:0043150
GO:0046843
GO:0006302
GO:0000724
GO:0045003
GO:0008298
GO:0000711
GO:0007067
GO:0048477
GO:0007131
GO:0006417
GO:0010212
Gene3D 3.40.50.300
InterPro IPR014001
IPR001650
IPR027417
IPR013967
IPR000330
Pfam PF00271
PF08658
PF00176
SMART SM00487
SM00490
SUPFAM SSF52540
PROSITE PS51192
PS51194

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0071481

cellular response to X-ray

PMID:9315669[1]

IMP: Inferred from Mutant Phenotype

P

Table 1

complete

GO:0000166

nucleotide binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

complete

GO:0000711

meiotic DNA repair synthesis

PMID:9732269[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0000724

double-strand break repair via homologous recombination

PMID:15105430[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0003674

molecular function

GO_REF:0000015

ND: No biological Data available

F

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000330

F

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

complete

GO:0004386

helicase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

complete

GO:0004386

helicase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0347

F

complete

GO:0005515

protein binding

PMID:14605208[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q8T3Y0

F

complete

GO:0005515

protein binding

PMID:14605208[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VKM7

F

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000330

F

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001650

F

complete

GO:0005524

ATP binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0005634

nucleus

PMID:9732269[2]

IDA: Inferred from Direct Assay

C

complete

GO:0006281

DNA repair

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

complete

GO:0006281

DNA repair

PMID:10449356[5]

NAS: Non-traceable Author Statement

P

complete

GO:0006302

double-strand break repair

PMID:14616073[6]

TAS: Traceable Author Statement

P

complete

GO:0006302

double-strand break repair

PMID:9315669[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006338

chromatin remodeling

PMID:15105430[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006417

regulation of translation

PMID:9642168[7]

TAS: Traceable Author Statement

P

complete

GO:0006974

response to DNA damage stimulus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

complete

GO:0007049

cell cycle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

complete

GO:0007067

mitosis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0498

P

complete

GO:0007126

meiosis

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0469

P

complete

GO:0007131

reciprocal meiotic recombination

PMID:10021357[8]

TAS: Traceable Author Statement

P

complete

GO:0007131

reciprocal meiotic recombination

PMID:10449356[5]

TAS: Traceable Author Statement

P

complete

GO:0008298

intracellular mRNA localization

PMID:9642168[7]

TAS: Traceable Author Statement

P

complete

GO:0010212

response to ionizing radiation

PMID:14704177[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010212

response to ionizing radiation

PMID:9315669[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0016787

hydrolase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

complete

GO:0016817

hydrolase activity, acting on acid anhydrides

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013967

F

complete

GO:0030261

chromosome condensation

PMID:10449356[5]

TAS: Traceable Author Statement

P

complete

GO:0043150

DNA synthesis involved in double-strand break repair via homologous recombination

PMID:9732269[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045003

double-strand break repair via synthesis-dependent strand annealing

PMID:17660539[10]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0046843

dorsal appendage formation

PMID:1783295[11]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0048477

oogenesis

PMID:10449356[5]

TAS: Traceable Author Statement

P

complete

GO:0048477

oogenesis

PMID:1783295[11]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0048477

oogenesis

PMID:20522776[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0039044

P

complete

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0051301

cell division

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0132

P

complete

GO:0000711

meiotic DNA repair synthesis

PMID:9732269[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000724

double-strand break repair via homologous recombination

PMID:15105430[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003674

molecular_function

GO_REF:0000015

ND: No biological Data available

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0004386

helicase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000330

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:9732269[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006281

DNA repair

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

GO:0006281

DNA repair

PMID:10449356[5]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006302

double-strand break repair

PMID:14616073[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006302

double-strand break repair

PMID:9315669[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006310

DNA recombination

PMID:9315669[1]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0006338

chromatin remodeling

PMID:15105430[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006417

regulation of translation

PMID:9642168[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

Seeded From UniProt

complete

GO:0007131

reciprocal meiotic recombination

PMID:10021357[8]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007131

reciprocal meiotic recombination

PMID:10449356[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008298

intracellular mRNA localization

PMID:9642168[7]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0010212

response to ionizing radiation

PMID:14704177[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010212

response to ionizing radiation

PMID:9315669[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0030261

chromosome condensation

PMID:10449356[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043150

DNA synthesis involved in double-strand break repair via homologous recombination

PMID:9732269[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045003

double-strand break repair via synthesis-dependent strand annealing

PMID:17660539[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046843

dorsal appendage formation

PMID:1783295[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:10449356[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:1783295[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:20522776[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0039044

P

Seeded From UniProt

complete

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

GO:0051321

meiotic cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Kooistra, R et al. (1997) The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Mol. Cell. Biol. 17 6097-104 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Ghabrial, A et al. (1998) okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Genes Dev. 12 2711-23 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Alexiadis, V et al. (2004) A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing. J. Biol. Chem. 279 27824-9 PubMed GONUTS page
  4. 4.0 4.1 Giot, L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302 1727-36 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 van Eeden, F & St Johnston, D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr. Opin. Genet. Dev. 9 396-404 PubMed GONUTS page
  6. 6.0 6.1 Lee, LA & Orr-Weaver, TL (2003) Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu. Rev. Genet. 37 545-78 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Cooperstock, RL & Lipshitz, HD (1997) Control of mRNA stability and translation during Drosophila development. Semin. Cell Dev. Biol. 8 541-9 PubMed GONUTS page
  8. 8.0 8.1 Morris, J & Lehmann, R (1999) Drosophila oogenesis: versatile spn doctors. Curr. Biol. 9 R55-8 PubMed GONUTS page
  9. 9.0 9.1 Gorski, MM et al. (2003) The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Genetics 165 1929-41 PubMed GONUTS page
  10. 10.0 10.1 Wei, DS & Rong, YS (2007) A genetic screen for DNA double-strand break repair mutations in Drosophila. Genetics 177 63-77 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Schüpbach, T & Wieschaus, E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 1119-36 PubMed GONUTS page
  12. 12.0 12.1 Lu, WJ et al. (2010) Meiotic recombination provokes functional activation of the p53 regulatory network. Science 328 1278-81 PubMed GONUTS page