DROME:Q9Y1T2

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	No Information Provided. (synonyms: E-APC (ECO:0000313 with EMBL:AAD40227.1))
Protein Name(s)	Adenomatous polyposis coli 2 (ECO:0000313 with EMBL:AAD20985.2) Adenomatous polyposis coli tumor suppressor homolog 2 (ECO:0000313 with EMBL:AAF56249.1) Epithelial adenomatous polyposis coli (ECO:0000313 with EMBL:AAD40227.1)
External Links
UniProt	Q9Y1T2
EMBL	AF091430 AF113913 AE014297
RefSeq	NP_477430.1
UniGene	Dm.3113
SMR	Q9Y1T2
IntAct	Q9Y1T2
MINT	MINT-763536
EnsemblMetazoa	FBtr0084552
GeneID	42871
KEGG	dme:Dmel_CG6193
UCSC	CG6193-RA
CTD	10297
FlyBase	FBgn0026598
GeneTree	ENSGT00530000063749
KO	K02085
OMA	ASFDEEH
PhylomeDB	Q9Y1T2
Reactome	REACT_220429 REACT_229546 REACT_239929 REACT_241007 REACT_242866 REACT_248684 REACT_248764 REACT_248794 REACT_249265 REACT_251065 REACT_259707
GenomeRNAi	42871
NextBio	831014
Proteomes	UP000000803
GO	GO:0005912 GO:0045179 GO:0016327 GO:0030877 GO:0005938 GO:0032154 GO:0005737 GO:0030425 GO:0005875 GO:0043025 GO:0005634 GO:0043234 GO:0008017 GO:0007411 GO:0007420 GO:0007155 GO:0008362 GO:0035293 GO:0030866 GO:0040001 GO:0030951 GO:0008258 GO:0007447 GO:0021550 GO:0007017 GO:0045892 GO:0030178 GO:0007405 GO:0030720 GO:0045732 GO:0045862 GO:0030589 GO:0030111 GO:0016337 GO:0035190 GO:0016055
Gene3D	1.25.10.10
InterPro	IPR009240 IPR009223 IPR026818 IPR011989 IPR016024 IPR000225
PANTHER	PTHR12607
Pfam	PF05972 PF05923 PF00514
SMART	SM00185
SUPFAM	SSF48371
PROSITE	PS50176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009968	negative regulation of signal transduction	PMID:10491393^[1]	ECO:0000315			P		Figure 9	complete CACAO 5946
	GO:0007399	nervous system development	PMID:10491393^[1]	ECO:0000314			P		Figure 5	complete CACAO 5948
	GO:0000922	spindle pole	PMID:10491393^[1]	ECO:0000314			C		Figure 5	complete CACAO 6038
	GO:0060812	orthodenticle mRNA localization	PMID:10491393^[1]	ECO:0000314			P		Figure 6-(G) Stage 15 embryo labeled for dAPC2. Stripes of strong dAPC2 accumulation occur in the position of the developing denticles.	complete CACAO 6039
part_of	GO:0000922	spindle pole	PMID:10491393^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:10491393^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	PMID:10491393^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996 UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612	P		Seeded From UniProt	complete
enables	GO:0045295	gamma-catenin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288612 UniProtKB:P25054	F		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 PANTHER:PTN000288612 UniProtKB:P25054	C		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015589 FB:FBgn0026598 MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996 UniProtKB:P25054 WB:WBGene00000156	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612	P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:P25054	P		Seeded From UniProt	complete
colocalizes_with	GO:0005881	cytoplasmic microtubule	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88039 PANTHER:PTN000288612 UniProtKB:O95996	C		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000288612 WB:WBGene00000156	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:11923210^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:11862214^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030720	oocyte localization involved in germarium-derived egg chamber formation	PMID:11862214^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
involved_in	GO:0030720	oocyte localization involved in germarium-derived egg chamber formation	PMID:11862214^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:17470283^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:17470283^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19279137^[6]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0011202	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24257623^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035293	chitin-based larval cuticle pattern formation	PMID:12297098^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
involved_in	GO:0007447	imaginal disc pattern formation	PMID:12297098^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
involved_in	GO:0030589	pseudocleavage involved in syncytial blastoderm formation	PMID:19279137^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	PMID:19279137^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:19279137^[6]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0000117	F		Seeded From UniProt	complete
part_of	GO:0045180	basal cortex	PMID:24257623^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:24257623^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:12297098^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
part_of	GO:0045179	apical cortex	PMID:12297098^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:12297097^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030866	cortical actin cytoskeleton organization	PMID:21486956^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030589	pseudocleavage involved in syncytial blastoderm formation	PMID:21486956^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:11206549^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	PMID:21145742^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:12297097^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
involved_in	GO:0007405	neuroblast proliferation	PMID:12297097^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	PMID:12297097^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:16720878^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035190	syncytial nuclear migration	PMID:16720878^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008362	chitin-based embryonic cuticle biosynthetic process	PMID:16720878^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:10491393^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0284084	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:10491393^[1]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0000117	F		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:22359584^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:22174073^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:22174073^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:11923210^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11923210^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:11923210^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
involved_in	GO:0007367	segment polarity determination	PMID:26446838^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:26446838^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21471006^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:21471006^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035293	chitin-based larval cuticle pattern formation	PMID:21471006^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:21471006^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:29093440^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:27068743^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:22645652^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:22645652^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0060090	molecular adaptor activity	PMID:22645652^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	part_of:(GO:0090090) has_input:(FB:FBgn0026597) occurs_in:(GO:0030877)	Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:21471006^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_input:(FB:FBgn0000117) occurs_in:(GO:0005829) part_of:(GO:0090090)	Seeded From UniProt	complete
involved_in	GO:0035293	chitin-based larval cuticle pattern formation	PMID:11923210^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035293	chitin-based larval cuticle pattern formation	PMID:11923210^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015589	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009240 InterPro:IPR026818	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009223 InterPro:IPR009240	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026818	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	Reactome:R-DME-432626	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-881988 Reactome:R-DME-432559 Reactome:R-DME-209224 Reactome:R-DME-209172 Reactome:R-DME-209168 Reactome:R-DME-209134 Reactome:R-DME-209120 Reactome:R-DME-209109 Reactome:R-DME-209102 Reactome:R-DME-209097 Reactome:R-DME-209094 Reactome:R-DME-209081 Reactome:R-DME-209075	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 McCartney, BM et al. (1999) Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J. Cell Biol. 146 1303-18 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Ahmed, Y et al. (2002) Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. Development 129 1751-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Hamada, F & Bienz, M (2002) A Drosophila APC tumour suppressor homologue functions in cellular adhesion. Nat. Cell Biol. 4 208-13 PubMed GONUTS page
↑ ^5.0 ^5.1 Rolls, MM et al. (2007) Polarity and intracellular compartmentalization of Drosophila neurons. Neural Dev 2 7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Webb, RL et al. (2009) A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development 136 1283-93 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Komori, H et al. (2014) Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity. Development 141 51-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Akong, K et al. (2002) Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. Dev. Biol. 250 91-100 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Akong, K et al. (2002) Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev. Biol. 250 71-90 PubMed GONUTS page
↑ ^10.0 ^10.1 Zhou, MN et al. (2011) Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila. J. Cell. Sci. 124 1589-600 PubMed GONUTS page
↑ Lu, B et al. (2001) Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409 522-5 PubMed GONUTS page
↑ Mattie, FJ et al. (2010) Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr. Biol. 20 2169-77 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 McCartney, BM et al. (2006) Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 133 2407-18 PubMed GONUTS page
↑ Roberts, DM et al. (2012) Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. PLoS ONE 7 e31284 PubMed GONUTS page
↑ ^15.0 ^15.1 Kunttas-Tatli, E et al. (2012) Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo. Genetics 190 1059-75 PubMed GONUTS page
↑ ^16.0 ^16.1 Kunttas-Tatli, E et al. (2015) The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling. Mol. Biol. Cell 26 4503-18 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Roberts, DM et al. (2011) Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol. Biol. Cell 22 1845-63 PubMed GONUTS page
↑ Dai, W et al. (2017) Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate. Nat Commun 8 1244 PubMed GONUTS page
↑ Croy, HE et al. (2016) The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2. J. Biol. Chem. 291 12747-60 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Mendoza-Topaz, C et al. (2011) The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. Open Biol 1 110013 PubMed GONUTS page

[PMID:10491393-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 McCartney, BM et al. (1999) Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J. Cell Biol. 146 1303-18 PubMed GONUTS page

[PMID:21873635-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11923210-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Ahmed, Y et al. (2002) Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. Development 129 1751-62 PubMed GONUTS page

[PMID:11862214-4] 4.0 ^4.1 ^4.2 Hamada, F & Bienz, M (2002) A Drosophila APC tumour suppressor homologue functions in cellular adhesion. Nat. Cell Biol. 4 208-13 PubMed GONUTS page

[PMID:17470283-5] 5.0 ^5.1 Rolls, MM et al. (2007) Polarity and intracellular compartmentalization of Drosophila neurons. Neural Dev 2 7 PubMed GONUTS page

[PMID:19279137-6] 6.0 ^6.1 ^6.2 ^6.3 Webb, RL et al. (2009) A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development 136 1283-93 PubMed GONUTS page

[PMID:24257623-7] 7.0 ^7.1 ^7.2 Komori, H et al. (2014) Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity. Development 141 51-62 PubMed GONUTS page

[PMID:12297098-8] 8.0 ^8.1 ^8.2 ^8.3 Akong, K et al. (2002) Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. Dev. Biol. 250 91-100 PubMed GONUTS page

[PMID:12297097-9] 9.0 ^9.1 ^9.2 ^9.3 Akong, K et al. (2002) Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev. Biol. 250 71-90 PubMed GONUTS page

[PMID:21486956-10] 10.0 ^10.1 Zhou, MN et al. (2011) Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila. J. Cell. Sci. 124 1589-600 PubMed GONUTS page

[PMID:11206549-11] Lu, B et al. (2001) Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409 522-5 PubMed GONUTS page

[PMID:21145742-12] Mattie, FJ et al. (2010) Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr. Biol. 20 2169-77 PubMed GONUTS page

[PMID:16720878-13] 13.0 ^13.1 ^13.2 McCartney, BM et al. (2006) Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 133 2407-18 PubMed GONUTS page

[PMID:22359584-14] Roberts, DM et al. (2012) Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. PLoS ONE 7 e31284 PubMed GONUTS page

[PMID:22174073-15] 15.0 ^15.1 Kunttas-Tatli, E et al. (2012) Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo. Genetics 190 1059-75 PubMed GONUTS page

[PMID:26446838-16] 16.0 ^16.1 Kunttas-Tatli, E et al. (2015) The two SAMP repeats and their phosphorylation state in Drosophila Adenomatous polyposis coli-2 play mechanistically distinct roles in negatively regulating Wnt signaling. Mol. Biol. Cell 26 4503-18 PubMed GONUTS page

[PMID:21471006-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Roberts, DM et al. (2011) Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol. Biol. Cell 22 1845-63 PubMed GONUTS page

[PMID:29093440-18] Dai, W et al. (2017) Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate. Nat Commun 8 1244 PubMed GONUTS page

[PMID:27068743-19] Croy, HE et al. (2016) The Poly(ADP-ribose) Polymerase Enzyme Tankyrase Antagonizes Activity of the β-Catenin Destruction Complex through ADP-ribosylation of Axin and APC2. J. Biol. Chem. 291 12747-60 PubMed GONUTS page

[PMID:22645652-20] 20.0 ^20.1 ^20.2 Mendoza-Topaz, C et al. (2011) The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. Open Biol 1 110013 PubMed GONUTS page

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DROME:Q9Y1T2

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