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DROME:Q9Y1T2

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided. (synonyms: E-APC (ECO:0000313 with EMBL:AAD40227.1))
Protein Name(s) Adenomatous polyposis coli 2 (ECO:0000313 with EMBL:AAD20985.2)

Adenomatous polyposis coli tumor suppressor homolog 2 (ECO:0000313 with EMBL:AAF56249.1) Epithelial adenomatous polyposis coli (ECO:0000313 with EMBL:AAD40227.1)

External Links
UniProt Q9Y1T2
EMBL AF091430
AF113913
AE014297
RefSeq NP_477430.1
UniGene Dm.3113
SMR Q9Y1T2
IntAct Q9Y1T2
MINT MINT-763536
EnsemblMetazoa FBtr0084552
GeneID 42871
KEGG dme:Dmel_CG6193
UCSC CG6193-RA
CTD 10297
FlyBase FBgn0026598
GeneTree ENSGT00530000063749
KO K02085
OMA ASFDEEH
PhylomeDB Q9Y1T2
Reactome REACT_220429
REACT_229546
REACT_239929
REACT_241007
REACT_242866
REACT_248684
REACT_248764
REACT_248794
REACT_249265
REACT_251065
REACT_259707
GenomeRNAi 42871
NextBio 831014
Proteomes UP000000803
GO GO:0005912
GO:0045179
GO:0016327
GO:0030877
GO:0005938
GO:0032154
GO:0005737
GO:0030425
GO:0005875
GO:0043025
GO:0005634
GO:0043234
GO:0008017
GO:0007411
GO:0007420
GO:0007155
GO:0008362
GO:0035293
GO:0030866
GO:0040001
GO:0030951
GO:0008258
GO:0007447
GO:0021550
GO:0007017
GO:0045892
GO:0030178
GO:0007405
GO:0030720
GO:0045732
GO:0045862
GO:0030589
GO:0030111
GO:0016337
GO:0035190
GO:0016055
Gene3D 1.25.10.10
InterPro IPR009240
IPR009223
IPR026818
IPR011989
IPR016024
IPR000225
PANTHER PTHR12607
Pfam PF05972
PF05923
PF00514
SMART SM00185
SUPFAM SSF48371
PROSITE PS50176

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0009968

negative regulation of signal transduction

PMID:10491393[1]

IMP: Inferred from Mutant Phenotype

P

Figure 9

complete
CACAO 5946

GO:0007399

nervous system development

PMID:10491393[1]

IDA: Inferred from Direct Assay

P

Figure 5

complete
CACAO 5948

GO:0000922

spindle pole

PMID:10491393[1]

IDA: Inferred from Direct Assay

C

Figure 5

complete
CACAO 6038

GO:0060812

orthodenticle mRNA localization

PMID:10491393[1]

IDA: Inferred from Direct Assay

P

Figure 6-(G) Stage 15 embryo labeled for dAPC2. Stripes of strong dAPC2 accumulation occur in the position of the developing denticles.

complete
CACAO 6039

GO:0000281

mitotic cytokinesis

PMID:11206549[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000922

spindle pole

PMID:10491393[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10491393[1]

IPI: Inferred from Physical Interaction

FB:FBgn0000117

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19279137[3]

IPI: Inferred from Physical Interaction

FB:FBgn0000117

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19279137[3]

IPI: Inferred from Physical Interaction

FB:FBgn0011202

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19279137[3]

IPI: Inferred from Physical Interaction

FB:FBgn0028421

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11988767[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11988767[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:24257623[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005875

microtubule associated complex

PMID:10908588[6]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005912

adherens junction

PMID:11782950[7]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005912

adherens junction

PMID:11988767[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:12297097[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:16720878[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:24257623[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007017

microtubule-based process

PMID:10908588[6]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0007017

microtubule-based process

PMID:11988767[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:11862214[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007155

cell adhesion

PMID:11988767[4]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007399

nervous system development

PMID:10491393[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007405

neuroblast proliferation

PMID:12297097[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0007411

axon guidance

PMID:17367777[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0007420

brain development

PMID:12297097[8]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0007447

imaginal disc pattern formation

PMID:12297098[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0008013

beta-catenin binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009240
InterPro:IPR026818

F

Seeded From UniProt

complete

GO:0008017

microtubule binding

PMID:10908588[6]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0008258

head involution

PMID:12297098[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0008362

chitin-based embryonic cuticle biosynthetic process

PMID:16720878[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009968

negative regulation of signal transduction

PMID:10491393[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR009223
InterPro:IPR009240

P

Seeded From UniProt

complete

GO:0016055

Wnt signaling pathway

PMID:12019232[13]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016327

apicolateral plasma membrane

PMID:11700298[14]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016327

apicolateral plasma membrane

PMID:11988767[4]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016337

single organismal cell-cell adhesion

PMID:17367777[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0021550

medulla oblongata development

PMID:17367777[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0030111

regulation of Wnt signaling pathway

PMID:11923210[15]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0030111

regulation of Wnt signaling pathway

PMID:11923210[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030111

regulation of Wnt signaling pathway

PMID:12297098[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0030178

negative regulation of Wnt signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR026818

P

Seeded From UniProt

complete

GO:0030178

negative regulation of Wnt signaling pathway

PMID:10491393[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0004009

P

Seeded From UniProt

complete

GO:0030178

negative regulation of Wnt signaling pathway

PMID:17367777[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0030425

dendrite

PMID:17470283[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0030589

pseudocleavage involved in syncytial blastoderm formation

PMID:19279137[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030589

pseudocleavage involved in syncytial blastoderm formation

PMID:21486956[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030720

oocyte localization involved in germarium-derived egg chamber formation

PMID:11862214[10]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0030720

oocyte localization involved in germarium-derived egg chamber formation

PMID:11862214[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030866

cortical actin cytoskeleton organization

PMID:21486956[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030877

beta-catenin destruction complex

PMID:21471006[18]

IC: Inferred by Curator

GO:0045732

C

Seeded From UniProt

complete

GO:0030877

beta-catenin destruction complex

PMID:21471006[18]

IPI: Inferred from Physical Interaction

FB:FBgn0026597

C

Seeded From UniProt

complete

GO:0030951

establishment or maintenance of microtubule cytoskeleton polarity

PMID:21145742[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032154

cleavage furrow

PMID:12297097[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0035190

syncytial nuclear migration

PMID:16720878[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035293

chitin-based larval cuticle pattern formation

PMID:12297098[12]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0040001

establishment of mitotic spindle localization

PMID:11988767[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0040001

establishment of mitotic spindle localization

PMID:12185850[20]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0043025

neuronal cell body

PMID:17470283[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0043234

protein complex

PMID:19279137[3]

IPI: Inferred from Physical Interaction

FB:FBgn0011202

C

Seeded From UniProt

complete

GO:0045179

apical cortex

PMID:12297098[12]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045180

basal cortex

PMID:24257623[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045732

positive regulation of protein catabolic process

PMID:21471006[18]

IGI: Inferred from Genetic Interaction

FB:FBgn0015589

P

Seeded From UniProt

complete

GO:0045862

positive regulation of proteolysis

PMID:11988767[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0045892

negative regulation of transcription, DNA-templated

PMID:11988767[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

colocalizes_with

GO:0005884

actin filament

PMID:19279137[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 McCartney, BM et al. (1999) Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J. Cell Biol. 146 1303-18 PubMed GONUTS page
  2. Lu, B et al. (2001) Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409 522-5 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Webb, RL et al. (2009) A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Development 136 1283-93 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Bienz, M (2002) The subcellular destinations of APC proteins. Nat. Rev. Mol. Cell Biol. 3 328-38 PubMed GONUTS page
  5. 5.0 5.1 5.2 Komori, H et al. (2014) Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity. Development 141 51-62 PubMed GONUTS page
  6. 6.0 6.1 6.2 Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
  7. Johnston, LA & Gallant, P (2002) Control of growth and organ size in Drosophila. Bioessays 24 54-64 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Akong, K et al. (2002) Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Dev. Biol. 250 71-90 PubMed GONUTS page
  9. 9.0 9.1 9.2 McCartney, BM et al. (2006) Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 133 2407-18 PubMed GONUTS page
  10. 10.0 10.1 10.2 Hamada, F & Bienz, M (2002) A Drosophila APC tumour suppressor homologue functions in cellular adhesion. Nat. Cell Biol. 4 208-13 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Hayden, MA et al. (2007) Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development. Dev. Biol. 305 358-76 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 Akong, K et al. (2002) Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. Dev. Biol. 250 91-100 PubMed GONUTS page
  13. Ostrowski, S et al. (2002) Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. Genetics 161 171-82 PubMed GONUTS page
  14. Tepass, U et al. (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 747-84 PubMed GONUTS page
  15. 15.0 15.1 Ahmed, Y et al. (2002) Drosophila Apc1 and Apc2 regulate Wingless transduction throughout development. Development 129 1751-62 PubMed GONUTS page
  16. 16.0 16.1 Rolls, MM et al. (2007) Polarity and intracellular compartmentalization of Drosophila neurons. Neural Dev 2 7 PubMed GONUTS page
  17. 17.0 17.1 Zhou, MN et al. (2011) Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila. J. Cell. Sci. 124 1589-600 PubMed GONUTS page
  18. 18.0 18.1 18.2 Roberts, DM et al. (2011) Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol. Biol. Cell 22 1845-63 PubMed GONUTS page
  19. Mattie, FJ et al. (2010) Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr. Biol. 20 2169-77 PubMed GONUTS page
  20. Gönczy, P (2002) Mechanisms of spindle positioning: focus on flies and worms. Trends Cell Biol. 12 332-9 PubMed GONUTS page