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DROME:Q9VH01
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | No Information Provided. | |
| Protein Name(s) | BIR-containing ubiquitin-conjugating enzyme (ECO:0000313 with EMBL:AAM77747.1)
Bruce (ECO:0000313 with EMBL:AAF54520.3) | |
| External Links | ||
| UniProt | Q9VH01 | |
| EMBL | AE014297 AF517634 | |
| RefSeq | NP_649995.2 | |
| UniGene | Dm.13678 | |
| SMR | Q9VH01 | |
| DIP | DIP-29548N | |
| IntAct | Q9VH01 | |
| MEROPS | I32.006 | |
| EnsemblMetazoa | FBtr0082239 | |
| GeneID | 41260 | |
| KEGG | dme:Dmel_CG6303 | |
| UCSC | CG6303-RA | |
| CTD | 41260 | |
| FlyBase | FBgn0266717 | |
| GeneTree | ENSGT00730000110680 | |
| KO | K10586 | |
| PhylomeDB | Q9VH01 | |
| GenomeRNAi | 41260 | |
| NextBio | 822968 | |
| PRO | PR:Q9VH01 | |
| Proteomes | UP000000803 | |
| GO | GO:0016881 GO:0004842 GO:0006915 GO:0032465 | |
| Gene3D | 1.10.1170.10 2.130.10.10 3.10.110.10 | |
| InterPro | IPR001370 IPR022103 IPR000608 IPR016135 IPR015943 | |
| Pfam | PF00653 PF12356 PF00179 | |
| SMART | SM00238 | |
| SUPFAM | SSF54495 | |
| PROSITE | PS50143 PS50127 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
P |
Figure 1: Mutant increases apoptosis associated with Reaper |
complete | |||||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007286 |
spermatid development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0012501 |
programmed cell death |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0011706 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048477 |
oogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016242 |
negative regulation of macroautophagy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0012501 |
programmed cell death |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0015946 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
MGI:MGI:1276108 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0061631 |
ubiquitin conjugating enzyme activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045849 |
negative regulation of nurse cell apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000209 |
protein polyubiquitination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009267 |
cellular response to starvation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004842 |
ubiquitin-protein transferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032465 |
regulation of cytokinesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Domingues, C & Ryoo, HD (2012) Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER. Cell Death Differ. 19 470-7 PubMed GONUTS page
- ↑ Arama, E et al. (2003) Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev. Cell 4 687-97 PubMed GONUTS page
- ↑ 3.0 3.1 Vernooy, SY et al. (2002) Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death. Curr. Biol. 12 1164-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Hou, YC et al. (2008) Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis. J. Cell Biol. 182 1127-39 PubMed GONUTS page
- ↑ Vernooy, SY et al. (2000) Cell death regulation in Drosophila: conservation of mechanism and unique insights. J. Cell Biol. 150 F69-76 PubMed GONUTS page
- ↑ Nezis, IP et al. (2010) Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J. Cell Biol. 190 523-31 PubMed GONUTS page
