DROME:Q9VA37

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	No Information Provided.
Protein Name(s)	DJ-1 beta (ECO:0000313 with EMBL:BAB84672.1) Dj-1beta (ECO:0000313 with EMBL:AAF57086.2) GH09983p (ECO:0000313 with EMBL:AAL28218.1)
External Links
UniProt	Q9VA37
EMBL	AE014297 AY060670 AB079599
RefSeq	NP_651825.3
UniGene	Dm.3914
PDB	4E08
PDBsum	4E08
SMR	Q9VA37
IntAct	Q9VA37
EnsemblMetazoa	FBtr0085703
GeneID	43652
KEGG	dme:Dmel_CG1349
UCSC	CG1349-RA
CTD	43652
FlyBase	FBgn0039802
eggNOG	COG0693
GeneTree	ENSGT00390000001231
OMA	MAGDHYK
OrthoDB	EOG7CVPZX
PhylomeDB	Q9VA37
GenomeRNAi	43652
NextBio	835079
PRO	PR:Q9VA37
Proteomes	UP000000803
GO	GO:0008344 GO:0070301 GO:0042775 GO:0048640 GO:0046626 GO:0006979
Gene3D	3.40.50.880
InterPro	IPR029062 IPR006287 IPR002818
Pfam	PF01965
SUPFAM	SSF52317
TIGRFAMs	TIGR01383

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006979	response to oxidative stress	PMID:16155123^[1]	ECO:0000315			P	Figure 3: DJ-1A RNAi leads to ROS accumulation and hypersensitivity to oxidative stress	complete
acts_upstream_of	GO:0008345	larval locomotory behavior	PMID:30540251^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:30540251^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900073	regulation of neuromuscular synaptic transmission	PMID:30540251^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:30540251^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P91634	P	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:30540251^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:30540251^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0036530	protein deglycation, methylglyoxal removal	PMID:27903648^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0009438	methylglyoxal metabolic process	PMID:27903648^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|involved_in	GO:0006517	protein deglycosylation	PMID:27903648^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0106046	guanine deglycation, glyoxal removal	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111103 UniProtKB:Q99497	P	Seeded From UniProt	complete
involved_in	GO:0036529	protein deglycation, glyoxal removal	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000111103 UniProtKB:Q99497	P	Seeded From UniProt	complete
enables	GO:0036524	protein deglycase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13272 PANTHER:PTN000111103 UniProtKB:Q99497	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG13272 MGI:MGI:2135637 PANTHER:PTN000111103 PomBase:SPAC22E12.03c RGD:621808 TAIR:locus:2086295 UniProtKB:C6KTB1 UniProtKB:Q99497	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2135637 PANTHER:PTN000111108 PomBase:SPAC22E12.03c RGD:621808 TAIR:locus:2086295 UniProtKB:Q99497 WB:WBGene00015184	C	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:23593018^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010310	regulation of hydrogen peroxide metabolic process	PMID:22983063^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048640	negative regulation of developmental growth	PMID:22983063^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1905446	regulation of mitochondrial ATP synthesis coupled electron transport	PMID:20457924^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0033885	P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:17651920^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:16894167^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:16203113^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008344	adult locomotory behavior	PMID:16203113^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:16139213^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:16139214^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0036524	protein deglycase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99497	F	Seeded From UniProt	complete
enables	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q99497	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016684	P	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yang, Y et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl. Acad. Sci. U.S.A. 102 13670-5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Oswald, MC et al. (2018) Reactive oxygen species regulate activity-dependent neuronal plasticity in . Elife 7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Pfaff, DH et al. (2017) Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. J. Biol. Chem. 292 685-690 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hwang, S et al. (2013) Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO. PLoS Genet. 9 e1003412 PubMed GONUTS page
↑ ^6.0 ^6.1 Stefanatos, R et al. (2012) dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle 11 3876-86 PubMed GONUTS page
↑ Hao, LY et al. (2010) DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc. Natl. Acad. Sci. U.S.A. 107 9747-52 PubMed GONUTS page
↑ Lavara-Culebras, E & Paricio, N (2007) Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits. Gene 400 158-65 PubMed GONUTS page
↑ Meulener, MC et al. (2006) Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc. Natl. Acad. Sci. U.S.A. 103 12517-22 PubMed GONUTS page
↑ ^10.0 ^10.1 Park, J et al. (2005) Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene 361 133-9 PubMed GONUTS page
↑ Meulener, M et al. (2005) Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr. Biol. 15 1572-7 PubMed GONUTS page
↑ Menzies, FM et al. (2005) Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr. Biol. 15 1578-82 PubMed GONUTS page

[PMID:16155123-1] Yang, Y et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl. Acad. Sci. U.S.A. 102 13670-5 PubMed GONUTS page

[PMID:30540251-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Oswald, MC et al. (2018) Reactive oxygen species regulate activity-dependent neuronal plasticity in . Elife 7 PubMed GONUTS page

[PMID:27903648-3] 3.0 ^3.1 ^3.2 Pfaff, DH et al. (2017) Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. J. Biol. Chem. 292 685-690 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23593018-5] Hwang, S et al. (2013) Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO. PLoS Genet. 9 e1003412 PubMed GONUTS page

[PMID:22983063-6] 6.0 ^6.1 Stefanatos, R et al. (2012) dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle 11 3876-86 PubMed GONUTS page

[PMID:20457924-7] Hao, LY et al. (2010) DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc. Natl. Acad. Sci. U.S.A. 107 9747-52 PubMed GONUTS page

[PMID:17651920-8] Lavara-Culebras, E & Paricio, N (2007) Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits. Gene 400 158-65 PubMed GONUTS page

[PMID:16894167-9] Meulener, MC et al. (2006) Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc. Natl. Acad. Sci. U.S.A. 103 12517-22 PubMed GONUTS page

[PMID:16203113-10] 10.0 ^10.1 Park, J et al. (2005) Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene 361 133-9 PubMed GONUTS page

[PMID:16139213-11] Meulener, M et al. (2005) Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr. Biol. 15 1572-7 PubMed GONUTS page

[PMID:16139214-12] Menzies, FM et al. (2005) Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr. Biol. 15 1578-82 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

DROME:Q9VA37

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

l

m

n

o

p

r

s

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools