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DROME:Q9VA37

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) DJ-1 beta (ECO:0000313 with EMBL:BAB84672.1)

Dj-1beta (ECO:0000313 with EMBL:AAF57086.2) GH09983p (ECO:0000313 with EMBL:AAL28218.1)

External Links
UniProt Q9VA37
EMBL AE014297
AY060670
AB079599
RefSeq NP_651825.3
UniGene Dm.3914
PDB 4E08
PDBsum 4E08
SMR Q9VA37
IntAct Q9VA37
EnsemblMetazoa FBtr0085703
GeneID 43652
KEGG dme:Dmel_CG1349
UCSC CG1349-RA
CTD 43652
FlyBase FBgn0039802
eggNOG COG0693
GeneTree ENSGT00390000001231
OMA MAGDHYK
OrthoDB EOG7CVPZX
PhylomeDB Q9VA37
GenomeRNAi 43652
NextBio 835079
PRO PR:Q9VA37
Proteomes UP000000803
GO GO:0008344
GO:0070301
GO:0042775
GO:0048640
GO:0046626
GO:0006979
Gene3D 3.40.50.880
InterPro IPR029062
IPR006287
IPR002818
Pfam PF01965
SUPFAM SSF52317
TIGRFAMs TIGR01383

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006979

response to oxidative stress

PMID:16155123[1]

IMP: Inferred from Mutant Phenotype

P

Figure 3: DJ-1A RNAi leads to ROS accumulation and hypersensitivity to oxidative stress

complete

GO:0006979

response to oxidative stress

PMID:16139213[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006979

response to oxidative stress

PMID:16139214[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006979

response to oxidative stress

PMID:16203113[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006979

response to oxidative stress

PMID:16894167[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006979

response to oxidative stress

PMID:17651920[6]

IDA: Inferred from Direct Assay

P

complete

GO:0008344

adult locomotory behavior

PMID:16203113[4]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005739

mitochondrion

PMID:20457924[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0033885

C

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:16139213[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:16139214[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:16203113[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:16894167[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:17651920[6]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:23593018[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008344

adult locomotory behavior

PMID:16203113[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042775

mitochondrial ATP synthesis coupled electron transport

PMID:20457924[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0033885

P

Seeded From UniProt

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:22983063[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048640

negative regulation of developmental growth

PMID:22983063[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0070301

cellular response to hydrogen peroxide

PMID:22983063[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Yang, Y et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl. Acad. Sci. U.S.A. 102 13670-5 PubMed GONUTS page
  2. 2.0 2.1 Meulener, M et al. (2005) Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr. Biol. 15 1572-7 PubMed GONUTS page
  3. 3.0 3.1 Menzies, FM et al. (2005) Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr. Biol. 15 1578-82 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Park, J et al. (2005) Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction. Gene 361 133-9 PubMed GONUTS page
  5. 5.0 5.1 Meulener, MC et al. (2006) Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc. Natl. Acad. Sci. U.S.A. 103 12517-22 PubMed GONUTS page
  6. 6.0 6.1 Lavara-Culebras, E & Paricio, N (2007) Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits. Gene 400 158-65 PubMed GONUTS page
  7. 7.0 7.1 Hao, LY et al. (2010) DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc. Natl. Acad. Sci. U.S.A. 107 9747-52 PubMed GONUTS page
  8. Hwang, S et al. (2013) Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO. PLoS Genet. 9 e1003412 PubMed GONUTS page
  9. 9.0 9.1 9.2 Stefanatos, R et al. (2012) dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle 11 3876-86 PubMed GONUTS page