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It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:Q9U779

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Rok (ECO:0000313 with FlyBase:FBgn0026181)
Protein Name(s) Rho-associated protein kinase (ECO:0000256 with PIRNR:PIRNR037568)
External Links
UniProt Q9U779
EMBL AF151375
ProteinModelPortal Q9U779
SMR Q9U779
STRING 7227.FBpp0074061
PRIDE Q9U779
FlyBase FBgn0026181
Reactome REACT_213797
REACT_238518
REACT_241007
REACT_250894
REACT_252605
REACT_263006
SignaLink Q9U779
Bgee Q9U779
ExpressionAtlas Q9U779
GO GO:0005856
GO:0005524
GO:0051020
GO:0046872
GO:0004674
GO:0030036
GO:0031532
GO:0032065
GO:0007391
GO:0008544
GO:0001737
GO:0042067
GO:0001736
GO:0045184
GO:0008335
GO:0035317
GO:0000281
GO:0007067
GO:0000022
GO:0016331
GO:0035191
GO:0007302
GO:0016318
GO:0007309
GO:0048599
GO:0007300
GO:0051496
GO:0090303
GO:0006468
GO:0032956
GO:0032231
GO:0050770
GO:1901888
GO:0008360
GO:0042325
GO:2000040
GO:0001932
GO:0007266
Gene3D 2.30.29.30
InterPro IPR000961
IPR011009
IPR029875
IPR002219
IPR001849
IPR011993
IPR000719
IPR017441
IPR015008
IPR020684
IPR002290
IPR008271
PANTHER PTHR22988:SF25
Pfam PF00069
PF08912
PIRSF PIRSF037568
SMART SM00109
SM00233
SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS50003
PS00107
PS50011
PS00108
PS50081

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000022

mitotic spindle elongation

PMID:16488869[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0000281

mitotic cytokinesis

PMID:15380073[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000281

mitotic cytokinesis

PMID:16174742[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000281

mitotic cytokinesis

PMID:16488869[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000281

mitotic cytokinesis

PMID:17205135[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0001736

establishment of planar polarity

PMID:12137730[5]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0001736

establishment of planar polarity

PMID:12414186[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0001737

establishment of imaginal disc-derived wing hair orientation

PMID:11301004[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001932

regulation of protein phosphorylation

PMID:11301004[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003384

apical constriction involved in gastrulation

PMID:25092658[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000961
InterPro:IPR020684
InterPro:IPR029875

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:10570971[9]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:10570971[9]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0004674

protein serine/threonine kinase activity

PMID:10908587[10]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:11301004[7]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:10570971[9]

IPI: Inferred from Physical Interaction

FB:FBgn0014020

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005856

cytoskeleton

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:12105185[11]

IMP: Inferred from Mutant Phenotype

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR008271

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[10]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

PMID:16488869[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007266

Rho protein signal transduction

PMID:10570971[9]

IPI: Inferred from Physical Interaction

FB:FBgn0014020

P

Seeded From UniProt

complete

GO:0007300

ovarian nurse cell to oocyte transport

PMID:16887114[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007302

nurse cell nucleus anchoring

PMID:16887114[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007309

oocyte axis specification

PMID:16887114[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12000787[13]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007391

dorsal closure

PMID:12147138[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008335

female germline ring canal stabilization

PMID:16887114[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008360

regulation of cell shape

PMID:16123312[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008544

epidermis development

PMID:17166923[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016318

ommatidial rotation

PMID:12000787[13]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0016331

morphogenesis of embryonic epithelium

PMID:16123312[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0017048

Rho GTPase binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015008

F

Seeded From UniProt

complete

GO:0030036

actin cytoskeleton organization

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020684

P

Seeded From UniProt

complete

GO:0030036

actin cytoskeleton organization

PMID:16887114[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031532

actin cytoskeleton reorganization

PMID:24388847[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032065

cortical protein anchoring

PMID:12105185[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032231

regulation of actin filament bundle assembly

PMID:11301004[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0000499

P

Seeded From UniProt

complete

GO:0032231

regulation of actin filament bundle assembly

PMID:11301004[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0001085

P

Seeded From UniProt

complete

GO:0032231

regulation of actin filament bundle assembly

PMID:11301004[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0032956

regulation of actin cytoskeleton organization

PMID:18207738[18]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035191

nuclear axial expansion

PMID:12105185[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035317

imaginal disc-derived wing hair organization

PMID:11301004[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0000499

P

Seeded From UniProt

complete

GO:0035317

imaginal disc-derived wing hair organization

PMID:11301004[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0001085

P

Seeded From UniProt

complete

GO:0035317

imaginal disc-derived wing hair organization

PMID:11301004[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035556

intracellular signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002219

P

Seeded From UniProt

complete

GO:0042067

establishment of ommatidial planar polarity

PMID:11301004[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042325

regulation of phosphorylation

PMID:17205135[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045184

establishment of protein localization

PMID:16174742[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0048599

oocyte development

PMID:16887114[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050770

regulation of axonogenesis

PMID:15572110[19]

IGI: Inferred from Genetic Interaction

FB:FBgn0041203

P

Seeded From UniProt

complete

GO:0051020

GTPase binding

PMID:11301004[7]

IPI: Inferred from Physical Interaction

FB:FBgn0014020

F

Seeded From UniProt

complete

GO:0051496

positive regulation of stress fiber assembly

PMID:24553290[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0266084

P

Seeded From UniProt

complete

GO:0090303

positive regulation of wound healing

PMID:24388847[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1901888

regulation of cell junction assembly

PMID:23707736[21]

IGI: Inferred from Genetic Interaction

FB:FBgn0026379

P

Seeded From UniProt

complete

GO:2000040

regulation of planar cell polarity pathway involved in axis elongation

PMID:20833361[22]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

colocalizes_with

GO:0045179

apical cortex

PMID:25092658[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Hickson, GR et al. (2006) Rho-kinase controls cell shape changes during cytokinesis. Curr. Biol. 16 359-70 PubMed GONUTS page
  2. Echard, A et al. (2004) Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14 1685-93 PubMed GONUTS page
  3. 3.0 3.1 Dean, SO et al. (2005) Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc. Natl. Acad. Sci. U.S.A. 102 13473-8 PubMed GONUTS page
  4. 4.0 4.1 Dean, SO & Spudich, JA (2006) Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS ONE 1 e131 PubMed GONUTS page
  5. Tree, DR et al. (2002) A three-tiered mechanism for regulation of planar cell polarity. Semin. Cell Dev. Biol. 13 217-24 PubMed GONUTS page
  6. Mlodzik, M (2002) Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet. 18 564-71 PubMed GONUTS page
  7. 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 Winter, CG et al. (2001) Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell 105 81-91 PubMed GONUTS page
  8. 8.0 8.1 Vasquez, CG et al. (2014) Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis. J. Cell Biol. 206 435-50 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Mizuno, T et al. (1999) Identification and characterization of Drosophila homolog of Rho-kinase. Gene 238 437-44 PubMed GONUTS page
  10. 10.0 10.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  11. 11.0 11.1 11.2 Royou, A et al. (2002) Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity. J. Cell Biol. 158 127-37 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 12.5 Verdier, V et al. (2006) Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis. Dev. Biol. 297 417-32 PubMed GONUTS page
  13. 13.0 13.1 Van Aelst, L & Symons, M (2002) Role of Rho family GTPases in epithelial morphogenesis. Genes Dev. 16 1032-54 PubMed GONUTS page
  14. Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
  15. 15.0 15.1 Dawes-Hoang, RE et al. (2005) folded gastrulation, cell shape change and the control of myosin localization. Development 132 4165-78 PubMed GONUTS page
  16. Ninov, N et al. (2007) Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis. Development 134 367-79 PubMed GONUTS page
  17. 17.0 17.1 Abreu-Blanco, MT et al. (2014) Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair. Curr. Biol. 24 144-55 PubMed GONUTS page
  18. Kunda, P et al. (2008) Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr. Biol. 18 91-101 PubMed GONUTS page
  19. Ng, J & Luo, L (2004) Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron 44 779-93 PubMed GONUTS page
  20. Lammel, U et al. (2014) The Drosophila FHOD1-like formin Knittrig acts through Rok to promote stress fiber formation and directed macrophage migration during the cellular immune response. Development 141 1366-80 PubMed GONUTS page
  21. Bardet, PL et al. (2013) PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue. Dev. Cell 25 534-46 PubMed GONUTS page
  22. Simões, Sde M et al. (2010) Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation. Dev. Cell 19 377-88 PubMed GONUTS page