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PMID:17205135

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Citation

Dean, SO and Spudich, JA (2006) Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS ONE 1:e131

Abstract

Myosin II recruitment to the equatorial cortex is one of the earliest events in establishment of the cytokinetic contractile ring. In Drosophila S2 cells, we previously showed that myosin II is recruited to the furrow independently of F-actin, and that Rho1 and Rok are essential for this recruitment [1]. Rok phosphorylates several cellular proteins, including the myosin regulatory light chain (RLC).

Links

PubMed PMC1762308 Online version:10.1371/journal.pone.0000131

Keywords

Animals; Base Sequence; Cell Line; Cytokinesis; Drosophila/cytology; Drosophila/genetics; Drosophila/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Mitosis; Myosin Light Chains/genetics; Myosin Light Chains/metabolism; Myosins/genetics; Myosins/metabolism; Phosphorylation; Protein-Serine-Threonine Kinases/genetics; Protein-Serine-Threonine Kinases/metabolism; RNA Interference; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; rho GTP-Binding Proteins/genetics; rho GTP-Binding Proteins/metabolism; rho-Associated Kinases/genetics; rho-Associated Kinases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:SQH

involved_in

GO:0000281: mitotic cytokinesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q961D4

involved_in

GO:0000281: mitotic cytokinesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q961D4

involved_in

GO:0042325: regulation of phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VXE3

involved_in

GO:0000281: mitotic cytokinesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VXE3

involved_in

GO:0042325: regulation of phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:X2JC83

involved_in

GO:0000281: mitotic cytokinesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:X2JC83

involved_in

GO:0042325: regulation of phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:X2JE40

involved_in

GO:0000281: mitotic cytokinesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:X2JE40

involved_in

GO:0042325: regulation of phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:X2JKQ8

involved_in

GO:0000281: mitotic cytokinesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:X2JKQ8

involved_in

GO:0042325: regulation of phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9U779

involved_in

GO:0000281: mitotic cytokinesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9U779

involved_in

GO:0042325: regulation of phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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