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It is now the 6th OPEN Period for CACAO Spring 2018! It will end on Monday April 23, 2018 at 05:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

It is now the 4th OPEN Period for CACAO Phage Hunters 2018! It will end on Sunday April 22, 2018 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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DROME:Q9U4J0

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) ETH (ECO:0000313 with FlyBase:FBgn0028738)
Protein Name(s) Ecdysis-triggering hormone (ECO:0000313 with EMBL:AAF14282.1)
External Links
UniProt Q9U4J0
EMBL AF170922
STRING 7227.FBpp0072331
PRIDE Q9U4J0
FlyBase FBgn0028738
eggNOG NOG119055
OrthoDB EOG7V7684
ChiTaRS Crc
crc
Bgee Q9U4J0
GO GO:0005615
GO:0008255
GO:0001664
GO:0005184
GO:0005102
GO:0018990
GO:0007218

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001664

G-protein coupled receptor binding

PMID:12586820[1]

IPI: Inferred from Physical Interaction

FB:FBgn0038874

F

Seeded From UniProt

complete

GO:0005102

receptor binding

PMID:12177421[2]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005184

neuropeptide hormone activity

PMID:11179818[3]

TAS: Traceable Author Statement

F

Seeded From UniProt

complete

GO:0005615

extracellular space

GO_REF:0000024

ISM: Inferred from Sequence Model

C

Seeded From UniProt

Missing: with/from

GO:0005615

extracellular space

PMID:10601653[4]

IC: Inferred by Curator

GO:0008255

C

Seeded From UniProt

complete

GO:0005615

extracellular space

PMID:16441518[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007218

neuropeptide signaling pathway

PMID:11179818[3]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007218

neuropeptide signaling pathway

PMID:16441518[5]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0008255

ecdysis-triggering hormone activity

PMID:10601653[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0008255

ecdysis-triggering hormone activity

PMID:11381038[6]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0018990

ecdysis, chitin-based cuticle

PMID:10601653[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0018990

ecdysis, chitin-based cuticle

PMID:11807040[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Park, Y et al. (2003) Two subtypes of ecdysis-triggering hormone receptor in Drosophila melanogaster. J. Biol. Chem. 278 17710-5 PubMed GONUTS page
  2. Park, Y et al. (2002) Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc. Natl. Acad. Sci. U.S.A. 99 11423-8 PubMed GONUTS page
  3. 3.0 3.1 Vanden Broeck, J (2001) Neuropeptides and their precursors in the fruitfly, Drosophila melanogaster. Peptides 22 241-54 PubMed GONUTS page
  4. 4.0 4.1 4.2 Park, Y et al. (1999) Molecular cloning and biological activity of ecdysis-triggering hormones in Drosophila melanogaster. FEBS Lett. 463 133-8 PubMed GONUTS page
  5. 5.0 5.1 Wegener, C et al. (2006) Direct mass spectrometric peptide profiling and fragmentation of larval peptide hormone release sites in Drosophila melanogaster reveals tagma-specific peptide expression and differential processing. J. Neurochem. 96 1362-74 PubMed GONUTS page
  6. Hewes, RS & Taghert, PH (2001) Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome. Genome Res. 11 1126-42 PubMed GONUTS page
  7. Park, Y et al. (2002) Deletion of the ecdysis-triggering hormone gene leads to lethal ecdysis deficiency. Development 129 493-503 PubMed GONUTS page