PMID:11381038

Citation	Hewes, RS and Taghert, PH (2001) Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome. Genome Res. 11:1126-42
Abstract	Recent genetic analyses in worms, flies, and mammals illustrate the importance of bioactive peptides in controlling numerous complex behaviors, such as feeding and circadian locomotion. To pursue a comprehensive genetic analysis of bioactive peptide signaling, we have scanned the recently completed Drosophila genome sequence for G protein-coupled receptors sensitive to bioactive peptides (peptide GPCRs). Here we describe 44 genes that represent the vast majority, and perhaps all, of the peptide GPCRs encoded in the fly genome. We also scanned for genes encoding potential ligands and describe 22 bioactive peptide precursors. At least 32 Drosophila peptide receptors appear to have evolved from common ancestors of 15 monophyletic vertebrate GPCR subgroups (e.g., the ancestral gastrin/cholecystokinin receptor). Six pairs of receptors are paralogs, representing recent gene duplications. Together, these findings shed light on the evolutionary history of peptide GPCRs, and they provide a template for physiological and genetic analyses of peptide signaling in Drosophila.
Links	PubMed PMC311076 Online version:10.1101/gr.169901
Keywords	Animals; Drosophila Proteins; Drosophila melanogaster/genetics; GTP-Binding Proteins/metabolism; Genome; Insect Proteins/genetics; Ligands; Multigene Family; Neuropeptides/genetics; Neuropeptides/metabolism; Peptides/genetics; Receptors, Cell Surface/genetics; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Receptors, Neuropeptide/classification; Receptors, Neuropeptide/genetics; Receptors, Neuropeptide/metabolism
edit table

Annotations

Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
edit table

References

See Help:References for how to manage references in GONUTS.