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DROME:Q7KT06

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) CG14396-PA, isoform A (ECO:0000313 with EMBL:AAF53977.3)

Ret oncogene, isoform B (ECO:0000313 with EMBL:AAF53978.2) Ret oncogene, isoform C (ECO:0000313 with EMBL:AAN11101.1)

External Links
UniProt Q7KT06
EMBL AE003669
AE014134
AE014134
RefSeq NP_477044.1
NP_724315.1
NP_724316.1
ProteinModelPortal Q7KT06
EnsemblMetazoa FBtr0081493
FBtr0081494
FBtr0081495
FBtr0081496
GeneID 43875
KEGG dme:Dmel_CG14396
UCSC CG14396-RA
CTD 5979
FlyBase FBgn0011829
GeneTree ENSGT00760000118923
KO K05126
GenomeRNAi 43875
NextBio 836275
Proteomes UP000000803
GO GO:0005887
GO:0005886
GO:0005524
GO:0004713
GO:0004714
GO:0018108
GO:0006468
GO:0007165
InterPro IPR011009
IPR000719
IPR017441
IPR001245
IPR008266
IPR020635
Pfam PF07714
PRINTS PR00109
SMART SM00219
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00109

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

GO:0004713

protein tyrosine kinase activity

PMID:10908587[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

F

Seeded From UniProt

complete

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:8199050[2]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005509

calcium ion binding

PMID:11445581[3]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9967

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:8199050[2]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005887

integral component of plasma membrane

PMID:11445581[3]

ISS: Inferred from Sequence or Structural Similarity

HGNC:9967

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

PMID:15978587[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266
InterPro:IPR020635

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:8199050[2]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0007165

signal transduction

PMID:8199050[2]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0016301

kinase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020635

P

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.10.1

P

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0829

P

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:10908587[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:8199050[2]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Sugaya, R et al. (1994) A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells. Mech. Dev. 45 139-45 PubMed GONUTS page
  3. 3.0 3.1 Anders, J et al. (2001) Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. J. Biol. Chem. 276 35808-17 PubMed GONUTS page
  4. Abrescia, C et al. (2005) Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells. FEBS Lett. 579 3789-96 PubMed GONUTS page