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DROME:Q7KT06
Contents
Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
Gene Name(s) | No Information Provided. | |
Protein Name(s) | CG14396-PA, isoform A (ECO:0000313 with EMBL:AAF53977.3)
Ret oncogene, isoform B (ECO:0000313 with EMBL:AAF53978.2) Ret oncogene, isoform C (ECO:0000313 with EMBL:AAN11101.1) | |
External Links | ||
UniProt | Q7KT06 | |
EMBL | AE003669 AE014134 AE014134 | |
RefSeq | NP_477044.1 NP_724315.1 NP_724316.1 | |
ProteinModelPortal | Q7KT06 | |
EnsemblMetazoa | FBtr0081493 FBtr0081494 FBtr0081495 FBtr0081496 | |
GeneID | 43875 | |
KEGG | dme:Dmel_CG14396 | |
UCSC | CG14396-RA | |
CTD | 5979 | |
FlyBase | FBgn0011829 | |
GeneTree | ENSGT00760000118923 | |
KO | K05126 | |
GenomeRNAi | 43875 | |
NextBio | 836275 | |
Proteomes | UP000000803 | |
GO | GO:0005887 GO:0005886 GO:0005524 GO:0004713 GO:0004714 GO:0018108 GO:0006468 GO:0007165 | |
InterPro | IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 | |
Pfam | PF07714 | |
PRINTS | PR00109 | |
SMART | SM00219 | |
SUPFAM | SSF56112 | |
PROSITE | PS00107 PS50011 PS00109 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002521373 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043410 |
positive regulation of MAPK cascade |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002521373 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043235 |
receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015380 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0030424 |
axon |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002521374 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0011829 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0011829 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0011829 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003366 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003366 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003733 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050773 |
regulation of dendrite development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001954 |
positive regulation of cell-matrix adhesion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005178 |
integrin binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0004657 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0030425 |
dendrite |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007015 |
actin filament organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016358 |
dendrite development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005509 |
calcium ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
HGNC:9967 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
HGNC:9967 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
Missing: with/from | |||
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Hoyer, N et al. (2018) Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons. Cell Rep 24 2261-2272.e5 PubMed GONUTS page
- ↑ Plaza-Menacho, I et al. (2016) RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Rep 17 3319-3332 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Soba, P et al. (2015) The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. Elife 4 PubMed GONUTS page
- ↑ Abrescia, C et al. (2005) Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells. FEBS Lett. 579 3789-96 PubMed GONUTS page
- ↑ 6.0 6.1 Anders, J et al. (2001) Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. J. Biol. Chem. 276 35808-17 PubMed GONUTS page
- ↑ 7.0 7.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Sugaya, R et al. (1994) A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells. Mech. Dev. 45 139-45 PubMed GONUTS page
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- GO:0018108 ! peptidyl-tyrosine phosphorylation
- GO:0005886 ! plasma membrane
- GO:0043410 ! positive regulation of MAPK cascade
- GO:0001954 ! positive regulation of cell-matrix adhesion
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004713 ! protein tyrosine kinase activity
- Pterygota