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DROME:Q7KT06

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) No Information Provided.
Protein Name(s) CG14396-PA, isoform A (ECO:0000313 with EMBL:AAF53977.3)

Ret oncogene, isoform B (ECO:0000313 with EMBL:AAF53978.2) Ret oncogene, isoform C (ECO:0000313 with EMBL:AAN11101.1)

External Links
UniProt Q7KT06
EMBL AE003669
AE014134
AE014134
RefSeq NP_477044.1
NP_724315.1
NP_724316.1
ProteinModelPortal Q7KT06
EnsemblMetazoa FBtr0081493
FBtr0081494
FBtr0081495
FBtr0081496
GeneID 43875
KEGG dme:Dmel_CG14396
UCSC CG14396-RA
CTD 5979
FlyBase FBgn0011829
GeneTree ENSGT00760000118923
KO K05126
GenomeRNAi 43875
NextBio 836275
Proteomes UP000000803
GO GO:0005887
GO:0005886
GO:0005524
GO:0004713
GO:0004714
GO:0018108
GO:0006468
GO:0007165
InterPro IPR011009
IPR000719
IPR017441
IPR001245
IPR008266
IPR020635
Pfam PF07714
PRINTS PR00109
SMART SM00219
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00109

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051897

positive regulation of protein kinase B signaling

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521373
UniProtKB:P07949

P

Seeded From UniProt

complete

involved_in

GO:0043410

positive regulation of MAPK cascade

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521373
UniProtKB:P07949

P

Seeded From UniProt

complete

part_of

GO:0043235

receptor complex

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015380
FB:FBgn0024245
FB:FBgn0033791
PANTHER:PTN002356460
UniProtKB:A6QR62
UniProtKB:O15146
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P17948
UniProtKB:P21860
UniProtKB:P35916
UniProtKB:Q01973
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16288
UniProtKB:Q16620

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521374
RGD:3556

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011829
MGI:MGI:97902
PANTHER:PTN002521432
RGD:3556
UniProtKB:P07949
ZFIN:ZDB-GENE-980526-307

P

Seeded From UniProt

complete

involved_in

GO:0022008

neurogenesis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011829
MGI:MGI:97902
PANTHER:PTN002521373
RGD:3556
UniProtKB:P07949

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011829
MGI:MGI:97902
PANTHER:PTN002521373
RGD:3556
UniProtKB:P07949
ZFIN:ZDB-GENE-980526-307

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0283499
MGI:MGI:104757
MGI:MGI:109378
MGI:MGI:1096337
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95278
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95523
MGI:MGI:95524
MGI:MGI:95525
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96575
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97531
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99216
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2612
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
RGD:69323
UniProtKB:A6QR62
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:P54764
UniProtKB:Q02763
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q15375
UniProtKB:Q16288
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
WB:WBGene00001184
WB:WBGene00006868
ZFIN:ZDB-GENE-020503-1
ZFIN:ZDB-GENE-020503-2
ZFIN:ZDB-GENE-060503-14
ZFIN:ZDB-GENE-070713-2
ZFIN:ZDB-GENE-980526-255
ZFIN:ZDB-GENE-980526-326
ZFIN:ZDB-GENE-990415-62

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003366
FB:FBgn0003731
FB:FBgn0003733
FB:FBgn0011829
FB:FBgn0015380
FB:FBgn0032006
FB:FBgn0283499
MGI:MGI:103581
MGI:MGI:104771
MGI:MGI:109378
MGI:MGI:98277
MGI:MGI:99611
PANTHER:PTN002356460
RGD:1560587
RGD:3213
RGD:3214
RGD:70957
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07949
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q02763
UniProtKB:Q16620
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00000898

C

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003733
FB:FBgn0040505
FB:FBgn0283499
MGI:MGI:109378
MGI:MGI:1339758
MGI:MGI:1345277
MGI:MGI:95276
MGI:MGI:95294
MGI:MGI:95522
MGI:MGI:95524
MGI:MGI:95558
MGI:MGI:95561
MGI:MGI:96677
MGI:MGI:96683
MGI:MGI:96969
MGI:MGI:97384
MGI:MGI:97530
MGI:MGI:97902
MGI:MGI:98277
MGI:MGI:99611
MGI:MGI:99612
MGI:MGI:99654
PANTHER:PTN002356460
RGD:2543
RGD:2611
RGD:2621
RGD:2869
RGD:2917
RGD:2965
RGD:3082
RGD:3213
RGD:3214
RGD:3284
RGD:3285
RGD:620144
RGD:620714
RGD:620831
RGD:621737
UniProtKB:P00533
UniProtKB:P04626
UniProtKB:P04629
UniProtKB:P06213
UniProtKB:P07333
UniProtKB:P07949
UniProtKB:P08069
UniProtKB:P09619
UniProtKB:P10721
UniProtKB:P11362
UniProtKB:P14616
UniProtKB:P16234
UniProtKB:P17948
UniProtKB:P21709
UniProtKB:P21802
UniProtKB:P22455
UniProtKB:P22607
UniProtKB:P29317
UniProtKB:P29320
UniProtKB:P35916
UniProtKB:P35968
UniProtKB:P54753
UniProtKB:P54760
UniProtKB:P54762
UniProtKB:Q08345
UniProtKB:Q15303
UniProtKB:Q16620
UniProtKB:Q16832
UniProtKB:Q5JZY3
UniProtKB:Q91987
UniProtKB:Q9UM73
WB:WBGene00000289
WB:WBGene00006868
WB:WBGene00020504
ZFIN:ZDB-GENE-980526-255

F

Seeded From UniProt

complete

involved_in

GO:0050773

regulation of dendrite development

PMID:30157422[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

PMID:28009299[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:25764303[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001954

positive regulation of cell-matrix adhesion

PMID:25764303[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

PMID:25764303[4]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0004657

F

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

PMID:25764303[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007015

actin filament organization

PMID:25764303[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016358

dendrite development

PMID:25764303[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:15978587[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:11445581[6]

ECO:0000250

sequence similarity evidence used in manual assertion

HGNC:9967

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:11445581[6]

ECO:0000250

sequence similarity evidence used in manual assertion

HGNC:9967

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:10908587[7]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:10908587[7]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:8199050[8]

ECO:0000250

sequence similarity evidence used in manual assertion

P

Seeded From UniProt

Missing: with/from

involved_in

GO:0006468

protein phosphorylation

PMID:8199050[8]

ECO:0000250

sequence similarity evidence used in manual assertion

P

Seeded From UniProt

Missing: with/from

part_of

GO:0005886

plasma membrane

PMID:8199050[8]

ECO:0000250

sequence similarity evidence used in manual assertion

C

Seeded From UniProt

Missing: with/from

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

PMID:8199050[8]

ECO:0000250

sequence similarity evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004713

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

involved_in

GO:0018108

peptidyl-tyrosine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004714

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266
InterPro:IPR020635

P

Seeded From UniProt

complete

enables

GO:0004714

transmembrane receptor protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.1

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. Hoyer, N et al. (2018) Ret and Substrate-Derived TGF-β Maverick Regulate Space-Filling Dendrite Growth in Drosophila Sensory Neurons. Cell Rep 24 2261-2272.e5 PubMed GONUTS page
  3. Plaza-Menacho, I et al. (2016) RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Rep 17 3319-3332 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Soba, P et al. (2015) The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. Elife 4 PubMed GONUTS page
  5. Abrescia, C et al. (2005) Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells. FEBS Lett. 579 3789-96 PubMed GONUTS page
  6. 6.0 6.1 Anders, J et al. (2001) Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. J. Biol. Chem. 276 35808-17 PubMed GONUTS page
  7. 7.0 7.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 Sugaya, R et al. (1994) A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells. Mech. Dev. 45 139-45 PubMed GONUTS page