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PMID:8199050
| Citation |
Sugaya, R, Ishimaru, S, Hosoya, T, Saigo, K and Emori, Y (1994) A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells. Mech. Dev. 45:139-45 |
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| Abstract |
We have identified a Drosophila gene encoding a putative receptor tyrosine kinase by screening a genomic DNA library with a DNA probe for a Drosophila homolog of fibroblast growth factor receptors. The newly isolated gene codes for a transmembrane protein most similar in sequence to a mammalian proto-oncogene ret; thus, the gene was termed Dret. Dret mRNA is transcribed in very small amounts in the embryonic, larval, and pupal stages. Whole mount in situ hybridization experiments revealed that the mRNA is transiently expressed in neuroblasts in early embryos. In late embryos, Dret mRNA was detected in subpopulations of differentiating CNS and PNS cells. In addition, Dret expression was affected in neurogenic mutants. These results suggest that Dret can be considered as a functional homolog of mammalian ret and should play important roles in neurogenesis. |
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| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Central Nervous System/abnormalities; Central Nervous System/embryology; Central Nervous System/metabolism; Drosophila/embryology; Drosophila/genetics; Drosophila/growth & development; Drosophila Proteins; Gene Expression Regulation; Humans; In Situ Hybridization; Larva; Molecular Sequence Data; Mutation; Nerve Tissue Proteins/biosynthesis; Nerve Tissue Proteins/genetics; Neurons/metabolism; Proto-Oncogene Proteins/biosynthesis; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-ret; Pupa; Receptor Protein-Tyrosine Kinases/biosynthesis; Receptor Protein-Tyrosine Kinases/genetics; Sequence Alignment; Sequence Homology; Sequence Homology, Amino Acid; Species Specificity |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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