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DROME:PHYL

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) phyl
Protein Name(s) Protein phyllopod
External Links
UniProt Q27934
EMBL L38294
U19722
U19731
AE013599
AY075531
BT072878
PIR A55647
RefSeq NP_725394.1
UniGene Dm.5449
PDB 4I7B
4I7C
4I7D
PDBsum 4I7B
4I7C
4I7D
BioGrid 62356
DIP DIP-29101N
IntAct Q27934
MINT MINT-282993
STRING 7227.FBpp0086645
EnsemblMetazoa FBtr0087516
GeneID 36606
KEGG dme:Dmel_CG10108
UCSC CG10108-RA
CTD 36606
FlyBase FBgn0013725
eggNOG NOG120590
InParanoid Q27934
OMA INIYEPR
OrthoDB EOG712TZR
PhylomeDB Q27934
GenomeRNAi 36606
NextBio 799468
Proteomes UP000000803
Bgee Q27934
GO GO:0005634
GO:0000151
GO:0060090
GO:0030674
GO:0043621
GO:0008270
GO:0007049
GO:0001751
GO:0046331
GO:0007219
GO:0007422
GO:0010498
GO:0007462
GO:0045467
GO:0007465
GO:0007265
GO:0008593
GO:0030111
GO:0008052
GO:0016360
GO:0007601
InterPro IPR012934
Pfam PF07776

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0007423

sensory organ development

PMID:11526076[1]

IMP: Inferred from Mutant Phenotype

P

Figures 1, 2, and 3

complete
CACAO 3565

GO:0000151

ubiquitin ligase complex

PMID:12215542[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0001751

compound eye photoreceptor cell differentiation

PMID:12215542[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11032805[3]

IPI: Inferred from Physical Interaction

UniProtKB:P21461

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11032805[3]

IPI: Inferred from Physical Interaction

UniProtKB:P21461

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11032805[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q95RJ9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11032805[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q95RJ9

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12215542[2]

IPI: Inferred from Physical Interaction

UniProtKB:P21461

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:12215542[2]

IPI: Inferred from Physical Interaction

UniProtKB:P42282

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14605208[4]

IPI: Inferred from Physical Interaction

UniProtKB:P21461

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:14605208[4]

IPI: Inferred from Physical Interaction

UniProtKB:P42282

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9267026[5]

IPI: Inferred from Physical Interaction

UniProtKB:P21461

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9267026[5]

IPI: Inferred from Physical Interaction

UniProtKB:P21461

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:9267026[5]

IPI: Inferred from Physical Interaction

UniProtKB:P42282

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:7859287[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:7859287[6]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007219

Notch signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

GO:0007265

Ras protein signal transduction

PMID:7888014[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0000097

P

Seeded From UniProt

complete

GO:0007265

Ras protein signal transduction

PMID:7888014[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0003079

P

Seeded From UniProt

complete

GO:0007265

Ras protein signal transduction

PMID:7888014[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0003205

P

Seeded From UniProt

complete

GO:0007265

Ras protein signal transduction

PMID:7888014[7]

IGI: Inferred from Genetic Interaction

FB:FBgn0004390

P

Seeded From UniProt

complete

GO:0007422

peripheral nervous system development

PMID:7888014[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007423

sensory organ development

PMID:11526076[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007462

R1/R6 cell fate commitment

PMID:7859287[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007462

R1/R6 cell fate commitment

PMID:7888014[7]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0007462

R1/R6 cell fate commitment

PMID:7888014[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007465

R7 cell fate commitment

PMID:7859287[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007465

R7 cell fate commitment

PMID:7888014[7]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0007465

R7 cell fate commitment

PMID:7888014[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007601

visual perception

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0844

P

Seeded From UniProt

complete

GO:0008052

sensory organ boundary specification

PMID:11526076[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008593

regulation of Notch signaling pathway

PMID:19153610[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0010498

proteasomal protein catabolic process

PMID:17962185[9]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016360

sensory organ precursor cell fate determination

PMID:11526076[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030111

regulation of Wnt signaling pathway

PMID:19153610[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0030674

protein binding, bridging

PMID:12215542[2]

IPI: Inferred from Physical Interaction

FB:FBgn0003410
FB:FBgn0003870

F

Seeded From UniProt

complete

GO:0043621

protein self-association

PMID:12215542[2]

IPI: Inferred from Physical Interaction

FB:FBgn0013725

F

Seeded From UniProt

complete

GO:0045467

R7 cell development

PMID:10929403[10]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046331

lateral inhibition

PMID:19363474[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050896

response to stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

GO:0060090

binding, bridging

PMID:17962185[9]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Pi, H et al. (2001) A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny. Development 128 2699-710 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Li, S et al. (2002) Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack. Mol. Cell. Biol. 22 6854-65 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Boulton, SJ et al. (2000) A role for Ebi in neuronal cell cycle control. EMBO J. 19 5376-86 PubMed GONUTS page
  4. 4.0 4.1 Giot, L et al. (2003) A protein interaction map of Drosophila melanogaster. Science 302 1727-36 PubMed GONUTS page
  5. 5.0 5.1 5.2 Tang, AH et al. (1997) PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell 90 459-67 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Dickson, BJ et al. (1995) Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell 80 453-62 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Chang, HC et al. (1995) phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80 463-72 PubMed GONUTS page
  8. 8.0 8.1 Nagaraj, R & Banerjee, U (2009) Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway. EMBO J. 28 337-46 PubMed GONUTS page
  9. 9.0 9.1 Cooper, SE et al. (2008) Two modes of degradation of the tramtrack transcription factors by Siah homologues. J. Biol. Chem. 283 1076-83 PubMed GONUTS page
  10. Kumar, JP & Moses, K (2000) Cell fate specification in the Drosophila retina. Results Probl Cell Differ 31 93-114 PubMed GONUTS page
  11. Mummery-Widmer, JL et al. (2009) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 458 987-92 PubMed GONUTS page