DROME:PHYL

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	phyl
Protein Name(s)	Protein phyllopod
External Links
UniProt	Q27934
EMBL	L38294 U19722 U19731 AE013599 AY075531 BT072878
PIR	A55647
RefSeq	NP_725394.1
UniGene	Dm.5449
PDB	4I7B 4I7C 4I7D
PDBsum	4I7B 4I7C 4I7D
BioGrid	62356
DIP	DIP-29101N
IntAct	Q27934
MINT	MINT-282993
STRING	7227.FBpp0086645
EnsemblMetazoa	FBtr0087516
GeneID	36606
KEGG	dme:Dmel_CG10108
UCSC	CG10108-RA
CTD	36606
FlyBase	FBgn0013725
eggNOG	NOG120590
InParanoid	Q27934
OMA	INIYEPR
OrthoDB	EOG712TZR
PhylomeDB	Q27934
GenomeRNAi	36606
NextBio	799468
Proteomes	UP000000803
Bgee	Q27934
GO	GO:0005634 GO:0000151 GO:0060090 GO:0030674 GO:0043621 GO:0008270 GO:0007049 GO:0001751 GO:0046331 GO:0007219 GO:0007422 GO:0010498 GO:0007462 GO:0045467 GO:0007465 GO:0007265 GO:0008593 GO:0030111 GO:0008052 GO:0016360 GO:0007601
InterPro	IPR012934
Pfam	PF07776

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007423	sensory organ development	PMID:11526076^[1]	ECO:0000315			P		Figures 1, 2, and 3	complete CACAO 3565
involved_in	GO:0007423	sensory organ development	PMID:11526076^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045746	negative regulation of Notch signaling pathway	PMID:19153610^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19153610^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010498	proteasomal protein catabolic process	PMID:17962185^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:1990756	protein binding, bridging involved in substrate recognition for ubiquitination	PMID:17962185^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:1990756	protein binding, bridging involved in substrate recognition for ubiquitination	PMID:12215542^[4]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0003410,FB:FBgn0003870	F		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	PMID:12215542^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007465	R7 cell fate commitment	PMID:12215542^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008052	sensory organ boundary specification	PMID:11526076^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016360	sensory organ precursor cell fate determination	PMID:11526076^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007465	R7 cell fate commitment	PMID:7859287^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7859287^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007462	R1/R6 cell fate commitment	PMID:7859287^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007465	R7 cell fate commitment	PMID:7888014^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007462	R1/R6 cell fate commitment	PMID:7888014^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007465	R7 cell fate commitment	PMID:7888014^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007462	R1/R6 cell fate commitment	PMID:7888014^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:12215542^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(FB:FBgn0003870)	Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:9267027^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(FB:FBgn0003870)	Seeded From UniProt	complete
involved_in	GO:0035883	enteroendocrine cell differentiation	PMID:29276156^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:29276156^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045500	sevenless signaling pathway	PMID:8722784^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007465	R7 cell fate commitment	PMID:8722784^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007465	R7 cell fate commitment	PMID:9267026^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003410	P		Seeded From UniProt	complete
involved_in	GO:0045500	sevenless signaling pathway	PMID:9267027^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0013725	P		Seeded From UniProt	complete
involved_in	GO:0045500	sevenless signaling pathway	PMID:7859287^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003079	P	part_of:(GO:0007465)	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1990756	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1990756	P		Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0844	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Pi, H et al. (2001) A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny. Development 128 2699-710 PubMed GONUTS page
↑ ^2.0 ^2.1 Nagaraj, R & Banerjee, U (2009) Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway. EMBO J. 28 337-46 PubMed GONUTS page
↑ ^3.0 ^3.1 Cooper, SE et al. (2008) Two modes of degradation of the tramtrack transcription factors by Siah homologues. J. Biol. Chem. 283 1076-83 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Li, S et al. (2002) Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack. Mol. Cell. Biol. 22 6854-65 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Dickson, BJ et al. (1995) Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell 80 453-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Chang, HC et al. (1995) phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80 463-72 PubMed GONUTS page
↑ ^7.0 ^7.1 Li, S et al. (1997) Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell 90 469-78 PubMed GONUTS page
↑ ^8.0 ^8.1 Yin, C & Xi, R (2018) A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila. Stem Cell Reports 10 43-57 PubMed GONUTS page
↑ ^9.0 ^9.1 Karim, FD et al. (1996) A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics 143 315-29 PubMed GONUTS page
↑ Tang, AH et al. (1997) PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell 90 459-67 PubMed GONUTS page

[PMID:11526076-1] 1.0 ^1.1 ^1.2 ^1.3 Pi, H et al. (2001) A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny. Development 128 2699-710 PubMed GONUTS page

[PMID:19153610-2] 2.0 ^2.1 Nagaraj, R & Banerjee, U (2009) Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway. EMBO J. 28 337-46 PubMed GONUTS page

[PMID:17962185-3] 3.0 ^3.1 Cooper, SE et al. (2008) Two modes of degradation of the tramtrack transcription factors by Siah homologues. J. Biol. Chem. 283 1076-83 PubMed GONUTS page

[PMID:12215542-4] 4.0 ^4.1 ^4.2 ^4.3 Li, S et al. (2002) Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack. Mol. Cell. Biol. 22 6854-65 PubMed GONUTS page

[PMID:7859287-5] 5.0 ^5.1 ^5.2 ^5.3 Dickson, BJ et al. (1995) Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase. Cell 80 453-62 PubMed GONUTS page

[PMID:7888014-6] 6.0 ^6.1 ^6.2 ^6.3 Chang, HC et al. (1995) phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila. Cell 80 463-72 PubMed GONUTS page

[PMID:9267027-7] 7.0 ^7.1 Li, S et al. (1997) Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack. Cell 90 469-78 PubMed GONUTS page

[PMID:29276156-8] 8.0 ^8.1 Yin, C & Xi, R (2018) A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem Cell Enteroendocrine Commitment in Drosophila. Stem Cell Reports 10 43-57 PubMed GONUTS page

[PMID:8722784-9] 9.0 ^9.1 Karim, FD et al. (1996) A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics 143 315-29 PubMed GONUTS page

[PMID:9267026-10] Tang, AH et al. (1997) PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism. Cell 90 459-67 PubMed GONUTS page

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DROME:PHYL

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