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DROME:PGSB1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) PGRP-SB1
Protein Name(s) Peptidoglycan-recognition protein SB1
External Links
UniProt Q70PY2
EMBL AJ556563
AJ556564
AJ556565
AJ556566
AJ556567
AJ556568
AJ556569
AJ556570
AJ556571
AJ556572
AJ556573
EF011112
AE014296
BT023240
BT029423
RefSeq NP_648917.1
UniGene Dm.24753
ProteinModelPortal Q70PY2
SMR Q70PY2
PaxDb Q70PY2
EnsemblMetazoa FBtr0075348
GeneID 39870
KEGG dme:Dmel_CG9681
CTD 39870
FlyBase FBgn0043578
eggNOG COG5479
GeneTree ENSGT00390000016833
InParanoid Q70PY2
KO K01446
OMA HRQTKAT
OrthoDB EOG757CZ5
PhylomeDB Q70PY2
BRENDA 3.5.1.28
GenomeRNAi 39870
NextBio 815805
Proteomes UP000000803
Bgee Q70PY2
GO GO:0005576
GO:0005875
GO:0008745
GO:0042834
GO:0008270
GO:0006955
GO:0045087
GO:0009253
Gene3D 3.40.80.10
InterPro IPR002502
IPR017331
IPR015510
IPR006619
PANTHER PTHR11022
Pfam PF01510
PIRSF PIRSF037945
SMART SM00644
SM00701
SUPFAM SSF55846

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:17046713[1]

ECO:0000314

F

Fig. 2. PGRP-SB1 possesses N-acetylmuramoyl l-alanine amidase activity.

complete
CACAO 12145

involved_in

GO:0045087

innate immune response

PMID:11106397[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042834

peptidoglycan binding

PMID:11106397[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009253

peptidoglycan catabolic process

PMID:11106397[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:11106397[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030310
FB:FBgn0030695
FB:FBgn0035806
FB:FBgn0037906
PANTHER:PTN001336553
UniProtKB:O75594
UniProtKB:Q96LB8
UniProtKB:Q96LB9
UniProtKB:Q96PD5

P

Seeded From UniProt

complete

enables

GO:0042834

peptidoglycan binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030310
FB:FBgn0033327
FB:FBgn0035806
FB:FBgn0035976
FB:FBgn0035977
PANTHER:PTN001664863
UniProtKB:O75594
UniProtKB:Q96LB8
UniProtKB:Q96LB9
UniProtKB:Q96PD5

F

Seeded From UniProt

complete

involved_in

GO:0032827

negative regulation of natural killer cell differentiation involved in immune response

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345092
MGI:MGI:1928099
MGI:MGI:2685266
MGI:MGI:2686324
PANTHER:PTN001336553

P

Seeded From UniProt

complete

involved_in

GO:0019730

antimicrobial humoral response

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035976
PANTHER:PTN001336553

P

Seeded From UniProt

complete

enables

GO:0016019

peptidoglycan receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035976
PANTHER:PTN001664864
UniProtKB:O75594
UniProtKB:Q96LB8
UniProtKB:Q96LB9
UniProtKB:Q96PD5

F

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033327
FB:FBgn0037906
FB:FBgn0043578
PANTHER:PTN001664864
UniProtKB:Q96PD5
ZFIN:ZDB-GENE-050419-71
ZFIN:ZDB-GENE-071227-2

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035806
PANTHER:PTN001664863

C

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:21364998[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:15199956[5]

ECO:0000250

sequence similarity evidence used in manual assertion

C

Seeded From UniProt

Missing: with/from

enables

GO:0042834

peptidoglycan binding

PMID:12496260[6]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0033327

F

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:12496260[6]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0033327

F

Seeded From UniProt

complete

involved_in

GO:0009253

peptidoglycan catabolic process

PMID:12496260[6]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0033327

P

Seeded From UniProt

complete

enables

GO:0042834

peptidoglycan binding

PMID:11106397[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O76537

F

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:11106397[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O76537

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:11106397[2]

ECO:0000250

sequence similarity evidence used in manual assertion

C

Seeded From UniProt

Missing: with/from

involved_in

GO:0002221

pattern recognition receptor signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016019

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006619

F

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002502
InterPro:IPR006619
InterPro:IPR036505

F

Seeded From UniProt

complete

involved_in

GO:0009253

peptidoglycan catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002502
InterPro:IPR006619
InterPro:IPR036505

P

Seeded From UniProt

complete

enables

GO:0042834

peptidoglycan binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017331

F

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017331

P

Seeded From UniProt

complete

enables

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.1.28

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Mellroth, P & Steiner, H (2006) PGRP-SB1: an N-acetylmuramoyl L-alanine amidase with antibacterial activity. Biochem. Biophys. Res. Commun. 350 994-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Werner, T et al. (2000) A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 97 13772-7 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Zaidman-Rémy, A et al. (2011) Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function. PLoS ONE 6 e17231 PubMed GONUTS page
  5. ↑ Steiner, H (2004) Peptidoglycan recognition proteins: on and off switches for innate immunity. Immunol. Rev. 198 83-96 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Mellroth, P et al. (2003) A scavenger function for a Drosophila peptidoglycan recognition protein. J. Biol. Chem. 278 7059-64 PubMed GONUTS page
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