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DROME:PGSB1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) PGRP-SB1
Protein Name(s) Peptidoglycan-recognition protein SB1
External Links
UniProt Q70PY2
EMBL AJ556563
AJ556564
AJ556565
AJ556566
AJ556567
AJ556568
AJ556569
AJ556570
AJ556571
AJ556572
AJ556573
EF011112
AE014296
BT023240
BT029423
RefSeq NP_648917.1
UniGene Dm.24753
ProteinModelPortal Q70PY2
SMR Q70PY2
PaxDb Q70PY2
EnsemblMetazoa FBtr0075348
GeneID 39870
KEGG dme:Dmel_CG9681
CTD 39870
FlyBase FBgn0043578
eggNOG COG5479
GeneTree ENSGT00390000016833
InParanoid Q70PY2
KO K01446
OMA HRQTKAT
OrthoDB EOG757CZ5
PhylomeDB Q70PY2
BRENDA 3.5.1.28
GenomeRNAi 39870
NextBio 815805
Proteomes UP000000803
Bgee Q70PY2
GO GO:0005576
GO:0005875
GO:0008745
GO:0042834
GO:0008270
GO:0006955
GO:0045087
GO:0009253
Gene3D 3.40.80.10
InterPro IPR002502
IPR017331
IPR015510
IPR006619
PANTHER PTHR11022
Pfam PF01510
PIRSF PIRSF037945
SMART SM00644
SM00701
SUPFAM SSF55846

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0002376

immune system process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

GO:0005576

extracellular region

PMID:11106397[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005576

extracellular region

PMID:11106397[1]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005576

extracellular region

PMID:15199956[2]

ISS: Inferred from Sequence or Structural Similarity

C

Seeded From UniProt

Missing: with/from

GO:0005875

microtubule associated complex

PMID:18433294[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006955

immune response

PMID:11106397[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O76537

P

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006619

F

Seeded From UniProt

complete

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002502
InterPro:IPR006619
InterPro:IPR015510

F

Seeded From UniProt

complete

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.5.1.28

F

Seeded From UniProt

complete

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:12496260[4]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0033327

F

Seeded From UniProt

complete

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:21364998[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0009253

peptidoglycan catabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002502
InterPro:IPR006619
InterPro:IPR015510

P

Seeded From UniProt

complete

GO:0009253

peptidoglycan catabolic process

PMID:11106397[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0009253

peptidoglycan catabolic process

PMID:12496260[4]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0033327

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0042834

peptidoglycan binding

PMID:11106397[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:O76537

F

Seeded From UniProt

complete

GO:0042834

peptidoglycan binding

PMID:11106397[1]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0042834

peptidoglycan binding

PMID:12496260[4]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0033327

F

Seeded From UniProt

complete

GO:0045087

innate immune response

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

GO:0045087

innate immune response

PMID:11106397[1]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

PMID:17046713[6]

IDA: Inferred from Direct Assay

F

Fig. 2. PGRP-SB1 possesses N-acetylmuramoyl l-alanine amidase activity.

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Werner, T et al. (2000) A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A. 97 13772-7 PubMed GONUTS page
  2. Steiner, H (2004) Peptidoglycan recognition proteins: on and off switches for innate immunity. Immunol. Rev. 198 83-96 PubMed GONUTS page
  3. Hughes, JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol. 6 e98 PubMed GONUTS page
  4. 4.0 4.1 4.2 Mellroth, P et al. (2003) A scavenger function for a Drosophila peptidoglycan recognition protein. J. Biol. Chem. 278 7059-64 PubMed GONUTS page
  5. Zaidman-Rémy, A et al. (2011) Drosophila immunity: analysis of PGRP-SB1 expression, enzymatic activity and function. PLoS ONE 6 e17231 PubMed GONUTS page
  6. Mellroth, P & Steiner, H (2006) PGRP-SB1: an N-acetylmuramoyl L-alanine amidase with antibacterial activity. Biochem. Biophys. Res. Commun. 350 994-9 PubMed GONUTS page