DROME:P91635

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Pi3K59F (ECO:0000313 with FlyBase:FBgn0015277) (synonyms: PI3K-59F (ECO:0000313 with EMBL:CAA68185.1))
Protein Name(s)	Phosphatidylinositol 3-kinase (ECO:0000256 with PIRNR:PIRNR000587)
External Links
UniProt	P91635
EMBL	X99912
ProteinModelPortal	P91635
SMR	P91635
PaxDb	P91635
PRIDE	P91635
FlyBase	FBgn0015277
eggNOG	COG5032
OrthoDB	EOG7PP55Z
BRENDA	2.7.1.137
Reactome	REACT_180727 REACT_180731 REACT_180733 REACT_220139 REACT_226659
SignaLink	P91635
Bgee	P91635
ExpressionAtlas	P91635
GO	GO:0000421 GO:0005769 GO:0035032 GO:0034271 GO:0016303 GO:0005524 GO:0035004 GO:0006914 GO:0009267 GO:0033227 GO:0006897 GO:0035096 GO:0046854 GO:0036092 GO:0048015 GO:0045850 GO:0010506
Gene3D	1.10.1070.11 1.25.40.70 2.60.40.150
InterPro	IPR016024 IPR000008 IPR011009 IPR000403 IPR018936 IPR002420 IPR008290 IPR015433 IPR001263
PANTHER	PTHR10048
Pfam	PF00454 PF00792 PF00613
PIRSF	PIRSF000587
SMART	SM00142 SM00145 SM00146
SUPFAM	SSF48371 SSF49562 SSF56112
PROSITE	PS00915 PS00916 PS50290 PS51547 PS51545

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:620899 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 FB:FBgn0015278 FB:FBgn0015279 FB:FBgn0267350 MGI:MGI:2448506 PANTHER:PTN000005673 RGD:620916 RGD:620917 SGD:S000004230 SGD:S000004296 SGD:S000005211 UniProtKB:A0A1D8PDV7 UniProtKB:P32871	P	Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445019 PANTHER:PTN000005955 PomBase:SPAC458.05 WB:WBGene00006932	P	Seeded From UniProt	complete
part_of	GO:0034272	phosphatidylinositol 3-kinase complex, class III, type II	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005955 SGD:S000004230	C	Seeded From UniProt	complete
part_of	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 PANTHER:PTN000005955 SGD:S000004230	C	Seeded From UniProt	complete
involved_in	GO:0030242	autophagy of peroxisome	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005955 SGD:S000004230	P	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 PANTHER:PTN000005955 PomBase:SPAC458.05 RGD:620899 SGD:S000004230 UniProtKB:A0A1D8PDV7 UniProtKB:Q8I3V5 UniProtKB:Q8NEB9 WB:WBGene00006932	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 PomBase:SPAC458.05 TAIR:locus:2164401 UniProtKB:P48736	C	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 PANTHER:PTN000005955 TAIR:locus:2036546 UniProtKB:A0A1D8PDV7 UniProtKB:Q8I3V5	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445019 PANTHER:PTN000005955 SGD:S000004230 UniProtKB:A0A1D8PDV7	P	Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005955 SGD:S000004230	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005955 SGD:S000004230	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:621214 UniProtKB:O00443 UniProtKB:P42356 UniProtKB:P48736 WB:WBGene00000090 WB:WBGene00006932 WB:WBGene00009552 dictyBase:DDB_G0291093	C	Seeded From UniProt	complete
part_of	GO:0000407	phagophore assembly site	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005955 SGD:S000004230	C	Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2445019 PANTHER:PTN000005955 RGD:620899	P	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:25882046^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035096	larval midgut cell programmed cell death	PMID:25882046^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	PMID:25458013^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:23873149^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035096	larval midgut cell programmed cell death	PMID:23873149^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:22952930^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045850	positive regulation of nurse cell apoptotic process	PMID:20713604^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:18474623^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0264325	P	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:18474623^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:18474623^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:18474623^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0000421	autophagosome membrane	PMID:18474623^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:18474623^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I	PMID:18474623^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0033227	dsRNA transport	PMID:16862146^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	PMID:10908587^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:10908587^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:9255069^[10]	ECO:0000250	sequence similarity evidence used in manual assertion	SGD:S000004230	F	Seeded From UniProt	complete
part_of	GO:0035032	phosphatidylinositol 3-kinase complex, class III	PMID:9255069^[10]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:9255069^[10]	ECO:0000250	sequence similarity evidence used in manual assertion	SGD:S000004230	P	Seeded From UniProt	complete
NOT\|enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	PMID:9032475^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:9032475^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
NOT\|enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PMID:9032475^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:9032475^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290	F	Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P	Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.137	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000114506	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000415644	F	Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000114506	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000415644	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 Xu, T et al. (2015) Distinct requirements of Autophagy-related genes in programmed cell death. Cell Death Differ. 22 1792-802 PubMed GONUTS page
↑ Issman-Zecharya, N & Schuldiner, O (2014) The PI3K class III complex promotes axon pruning by downregulating a Ptc-derived signal via endosome-lysosomal degradation. Dev. Cell 31 461-73 PubMed GONUTS page
↑ ^4.0 ^4.1 Chang, TK et al. (2013) Uba1 functions in Atg7- and Atg3-independent autophagy. Nat. Cell Biol. 15 1067-78 PubMed GONUTS page
↑ Pircs, K et al. (2012) Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PLoS ONE 7 e44214 PubMed GONUTS page
↑ Nezis, IP et al. (2010) Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J. Cell Biol. 190 523-31 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Juhász, G et al. (2008) The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J. Cell Biol. 181 655-66 PubMed GONUTS page
↑ Saleh, MC et al. (2006) The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat. Cell Biol. 8 793-802 PubMed GONUTS page
↑ ^9.0 ^9.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Vanhaesebroeck, B et al. (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22 267-72 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Linassier, C et al. (1997) Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase. Biochem. J. 321 ( Pt 3) 849-56 PubMed GONUTS page

[PMID:21873635-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25882046-2] 2.0 ^2.1 Xu, T et al. (2015) Distinct requirements of Autophagy-related genes in programmed cell death. Cell Death Differ. 22 1792-802 PubMed GONUTS page

[PMID:25458013-3] Issman-Zecharya, N & Schuldiner, O (2014) The PI3K class III complex promotes axon pruning by downregulating a Ptc-derived signal via endosome-lysosomal degradation. Dev. Cell 31 461-73 PubMed GONUTS page

[PMID:23873149-4] 4.0 ^4.1 Chang, TK et al. (2013) Uba1 functions in Atg7- and Atg3-independent autophagy. Nat. Cell Biol. 15 1067-78 PubMed GONUTS page

[PMID:22952930-5] Pircs, K et al. (2012) Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PLoS ONE 7 e44214 PubMed GONUTS page

[PMID:20713604-6] Nezis, IP et al. (2010) Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J. Cell Biol. 190 523-31 PubMed GONUTS page

[PMID:18474623-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Juhász, G et al. (2008) The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J. Cell Biol. 181 655-66 PubMed GONUTS page

[PMID:16862146-8] Saleh, MC et al. (2006) The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat. Cell Biol. 8 793-802 PubMed GONUTS page

[PMID:10908587-9] 9.0 ^9.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page

[PMID:9255069-10] 10.0 ^10.1 ^10.2 Vanhaesebroeck, B et al. (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22 267-72 PubMed GONUTS page

[PMID:9032475-11] 11.0 ^11.1 ^11.2 ^11.3 Linassier, C et al. (1997) Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase. Biochem. J. 321 ( Pt 3) 849-56 PubMed GONUTS page

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DROME:P91635

Contents

Annotations

Notes

References

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