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DROME:P91635

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Pi3K59F (ECO:0000313 with FlyBase:FBgn0015277) (synonyms: PI3K-59F (ECO:0000313 with EMBL:CAA68185.1))
Protein Name(s) Phosphatidylinositol 3-kinase (ECO:0000256 with PIRNR:PIRNR000587)
External Links
UniProt P91635
EMBL X99912
ProteinModelPortal P91635
SMR P91635
PaxDb P91635
PRIDE P91635
FlyBase FBgn0015277
eggNOG COG5032
OrthoDB EOG7PP55Z
BRENDA 2.7.1.137
Reactome REACT_180727
REACT_180731
REACT_180733
REACT_220139
REACT_226659
SignaLink P91635
Bgee P91635
ExpressionAtlas P91635
GO GO:0000421
GO:0005769
GO:0035032
GO:0034271
GO:0016303
GO:0005524
GO:0035004
GO:0006914
GO:0009267
GO:0033227
GO:0006897
GO:0035096
GO:0046854
GO:0036092
GO:0048015
GO:0045850
GO:0010506
Gene3D 1.10.1070.11
1.25.40.70
2.60.40.150
InterPro IPR016024
IPR000008
IPR011009
IPR000403
IPR018936
IPR002420
IPR008290
IPR015433
IPR001263
PANTHER PTHR10048
Pfam PF00454
PF00792
PF00613
PIRSF PIRSF000587
SMART SM00142
SM00145
SM00146
SUPFAM SSF48371
SSF49562
SSF56112
PROSITE PS00915
PS00916
PS50290
PS51547
PS51545

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000045

autophagosome assembly

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005955

P

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0000407

pre-autophagosomal structure

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005955

C

Seeded From UniProt

complete

GO:0000421

autophagosome membrane

PMID:18474623[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005673

C

Seeded From UniProt

complete

GO:0005769

early endosome

PMID:18474623[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005777

peroxisome

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005955

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005955

P

Seeded From UniProt

complete

GO:0006897

endocytosis

PMID:18474623[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006914

autophagy

PMID:18474623[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0264325

P

Seeded From UniProt

complete

GO:0006914

autophagy

PMID:18474623[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006914

autophagy

PMID:23873149[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009267

cellular response to starvation

PMID:18474623[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010506

regulation of autophagy

PMID:22952930[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016197

endosomal transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005955

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016303

1-phosphatidylinositol-3-kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008290

F

Seeded From UniProt

complete

GO:0016303

1-phosphatidylinositol-3-kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.1.137

F

Seeded From UniProt

complete

GO:0016303

1-phosphatidylinositol-3-kinase activity

PMID:9032475[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0016303

1-phosphatidylinositol-3-kinase activity

PMID:9255069[5]

ISS: Inferred from Sequence or Structural Similarity

SGD:S000004230

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016322

neuron remodeling

PMID:25458013[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000038

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000403
InterPro:IPR018936

F

Seeded From UniProt

complete

GO:0030242

pexophagy

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005955

P

Seeded From UniProt

complete

GO:0033227

dsRNA transport

PMID:16862146[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034271

phosphatidylinositol 3-kinase complex, class III, type I

PMID:18474623[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0034272

phosphatidylinositol 3-kinase complex, class III, type II

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005955

C

Seeded From UniProt

complete

GO:0035004

phosphatidylinositol 3-kinase activity

PMID:10908587[8]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0035032

phosphatidylinositol 3-kinase complex, class III

PMID:9255069[5]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0035096

larval midgut cell programmed cell death

PMID:23873149[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0036092

phosphatidylinositol-3-phosphate biosynthetic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005955

P

Seeded From UniProt

complete

GO:0045850

positive regulation of nurse cell apoptotic process

PMID:20713604[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046854

phosphatidylinositol phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008290
InterPro:IPR015433

P

Seeded From UniProt

complete

GO:0046854

phosphatidylinositol phosphorylation

PMID:10908587[8]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046854

phosphatidylinositol phosphorylation

PMID:9032475[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046854

phosphatidylinositol phosphorylation

PMID:9255069[5]

ISS: Inferred from Sequence or Structural Similarity

SGD:S000004230

P

Seeded From UniProt

complete

GO:0048015

phosphatidylinositol-mediated signaling

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008290
InterPro:IPR015433

P

Seeded From UniProt

complete

GO:0048015

phosphatidylinositol-mediated signaling

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000005673

P

Seeded From UniProt

complete

NOT

GO:0035005

1-phosphatidylinositol-4-phosphate 3-kinase activity

PMID:9032475[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

NOT

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

PMID:9032475[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Juhász, G et al. (2008) The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J. Cell Biol. 181 655-66 PubMed GONUTS page
  2. 2.0 2.1 Chang, TK et al. (2013) Uba1 functions in Atg7- and Atg3-independent autophagy. Nat. Cell Biol. 15 1067-78 PubMed GONUTS page
  3. Pircs, K et al. (2012) Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila. PLoS ONE 7 e44214 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Linassier, C et al. (1997) Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase. Biochem. J. 321 ( Pt 3) 849-56 PubMed GONUTS page
  5. 5.0 5.1 5.2 Vanhaesebroeck, B et al. (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci. 22 267-72 PubMed GONUTS page
  6. Issman-Zecharya, N & Schuldiner, O (2014) The PI3K class III complex promotes axon pruning by downregulating a Ptc-derived signal via endosome-lysosomal degradation. Dev. Cell 31 461-73 PubMed GONUTS page
  7. Saleh, MC et al. (2006) The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing. Nat. Cell Biol. 8 793-802 PubMed GONUTS page
  8. 8.0 8.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  9. Nezis, IP et al. (2010) Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J. Cell Biol. 190 523-31 PubMed GONUTS page