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DROME:NELFE
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | Nelf-E (synonyms: anon-66Da) | |
| Protein Name(s) | Negative elongation factor E | |
| External Links | ||
| UniProt | P92204 | |
| EMBL | Y10015 Y10016 AE014296 AY071061 | |
| RefSeq | NP_648241.1 | |
| UniGene | Dm.20046 | |
| ProteinModelPortal | P92204 | |
| SMR | P92204 | |
| BioGrid | 64390 | |
| IntAct | P92204 | |
| MINT | MINT-779659 | |
| STRING | 7227.FBpp0076374 | |
| PaxDb | P92204 | |
| PRIDE | P92204 | |
| EnsemblMetazoa | FBtr0076650 | |
| GeneID | 38982 | |
| KEGG | dme:Dmel_CG5994 | |
| CTD | 38982 | |
| FlyBase | FBgn0017430 | |
| eggNOG | NOG86140 | |
| GeneTree | ENSGT00630000089917 | |
| InParanoid | P92204 | |
| KO | K15182 | |
| OMA | YNDDVYK | |
| OrthoDB | EOG7SV0W7 | |
| PhylomeDB | P92204 | |
| Reactome | REACT_217308 REACT_221895 REACT_226178 | |
| SignaLink | P92204 | |
| GenomeRNAi | 38982 | |
| NextBio | 811294 | |
| PRO | PR:P92204 | |
| Proteomes | UP000000803 | |
| Bgee | P92204 | |
| GO | GO:0005694 GO:0032021 GO:0005634 GO:0008023 GO:0017053 GO:0003729 GO:0000166 GO:0003723 GO:0032785 GO:0034244 GO:0000122 GO:0007070 GO:0022008 GO:0045944 GO:0006368 | |
| Gene3D | 3.30.70.330 | |
| InterPro | IPR012677 IPR000504 | |
| Pfam | PF00076 | |
| SMART | SM00360 | |
| PROSITE | PS50102 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008148 |
negative transcription elongation factor activity |
ECO:0000315 |
F |
Fig 4. Mutants with RNAi against NELF-E show depletion in promoter proximal pausing, as detected by monitoring the reactivity of transcribed DNA to permanganate. |
complete | |||||
|
involved_in |
GO:0032785 |
negative regulation of DNA-templated transcription, elongation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0017053 |
transcriptional repressor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0008023 |
transcription elongation factor complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006368 |
transcription elongation from RNA polymerase II promoter |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034244 |
negative regulation of transcription elongation from RNA polymerase II promoter |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032021 |
NELF complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0010416 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032021 |
NELF complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Wu, CH et al. (2003) NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev. 17 1402-14 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Missra, A & Gilmour, DS (2010) Interactions between DSIF (DRB sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex. Proc. Natl. Acad. Sci. U.S.A. 107 11301-6 PubMed GONUTS page
- ↑ 3.0 3.1 Gilchrist, DA et al. (2008) NELF-mediated stalling of Pol II can enhance gene expression by blocking promoter-proximal nucleosome assembly. Genes Dev. 22 1921-33 PubMed GONUTS page
- ↑ Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
h
i
n
- GO:0032785 ! negative regulation of DNA-templated transcription, elongation
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0034244 ! negative regulation of transcription elongation by RNA polymerase II
- GO:0032021 ! NELF complex
- Neoptera
- GO:0003676 ! nucleic acid binding
- GO:0005634 ! nucleus
