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DROME:KPC2

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) inaC (synonyms: PKC2)
Protein Name(s) Protein kinase C, eye isozyme

Eye-PKC Inactivation no after-potential C protein Protein INAC Photoreceptor-specific PKC dPKC53E(EY)

External Links
UniProt P13677
EMBL J04845
AE013599
BT004495
PIR A32392
RefSeq NP_476863.1
UniGene Dm.4688
ProteinModelPortal P13677
SMR P13677
BioGrid 62602
DIP DIP-54N
IntAct P13677
MINT MINT-922757
STRING 7227.FBpp0086196
PaxDb P13677
PRIDE P13677
EnsemblMetazoa FBtr0087047
GeneID 36897
KEGG dme:Dmel_CG6518
CTD 36897
FlyBase FBgn0004784
eggNOG COG0515
GeneTree ENSGT00770000120449
InParanoid P13677
KO K02677
OMA MELPMNE
OrthoDB EOG77M8QM
PhylomeDB P13677
Reactome REACT_180303
REACT_180649
REACT_181313
REACT_184300
REACT_184321
REACT_209150
REACT_210687
REACT_211983
REACT_219169
REACT_237476
REACT_254810
REACT_259532
REACT_261064
REACT_263519
REACT_271456
SignaLink P13677
GenomeRNAi 36897
NextBio 800933
Proteomes UP000000803
Bgee P13677
GO GO:0016027
GO:0005886
GO:0016028
GO:0005524
GO:0004697
GO:0004674
GO:0008270
GO:0016062
GO:0019722
GO:0016477
GO:0016059
GO:0050962
GO:0008585
GO:0006909
GO:0030845
GO:0007602
GO:0006468
GO:0045471
GO:0009416
GO:0007601
Gene3D 2.60.40.150
InterPro IPR000961
IPR000008
IPR020454
IPR011009
IPR002219
IPR017892
IPR000719
IPR017441
IPR014375
IPR002290
IPR008271
Pfam PF00130
PF00168
PF00069
PF00433
PIRSF PIRSF000550
PRINTS PR00360
PR00008
SMART SM00109
SM00239
SM00133
SM00220
SUPFAM SSF49562
SSF56112
PROSITE PS51285
PS50004
PS00107
PS50011
PS00108
PS00479
PS50081

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0016062

adaptation of rhodopsin mediated signaling

PMID:9651370[1]

IGI: Inferred from Genetic Interaction

UniProtKB:Q24008


P

Figure 7

complete
CACAO 10118

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:10908587[2]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0004697

protein kinase C activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014375

F

Seeded From UniProt

complete

GO:0004697

protein kinase C activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.11.13

F

Seeded From UniProt

complete

GO:0004697

protein kinase C activity

PMID:2720775[3]

ISS: Inferred from Sequence or Structural Similarity

protein_id:AAA41871.1

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11342563[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q24008

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11342563[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q24008

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21703451[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q24008

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR014375
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005622

intracellular

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002219

C

Seeded From UniProt

complete

GO:0005622

intracellular

PMID:10611962[6]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:20462449[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR008271
InterPro:IPR014375
InterPro:IPR017892

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:10908587[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0006909

phagocytosis

PMID:16336044[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007601

visual perception

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0844

P

Seeded From UniProt

complete

GO:0007602

phototransduction

PMID:1962207[9]

IGI: Inferred from Genetic Interaction

FB:FBgn0003218

P

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014375

F

Seeded From UniProt

complete

GO:0008585

female gonad development

PMID:11970894[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009416

response to light stimulus

PMID:18256265[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016027

inaD signaling complex

PMID:10611962[6]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016027

inaD signaling complex

PMID:12765677[12]

TAS: Traceable Author Statement

C

Seeded From UniProt

complete

GO:0016028

rhabdomere

PMID:16301334[13]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016028

rhabdomere

PMID:1962207[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016059

deactivation of rhodopsin mediated signaling

PMID:10611962[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016059

deactivation of rhodopsin mediated signaling

PMID:11707492[14]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016059

deactivation of rhodopsin mediated signaling

PMID:1961249[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016059

deactivation of rhodopsin mediated signaling

PMID:1962207[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016059

deactivation of rhodopsin mediated signaling

PMID:8510756[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016062

adaptation of rhodopsin mediated signaling

PMID:10611962[6]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0016062

adaptation of rhodopsin mediated signaling

PMID:1961249[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016062

adaptation of rhodopsin mediated signaling

PMID:1962207[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016062

adaptation of rhodopsin mediated signaling

PMID:8510756[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016062

adaptation of rhodopsin mediated signaling

PMID:9651370[1]

IGI: Inferred from Genetic Interaction

UniProtKB:Q24008

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016477

cell migration

PMID:11970894[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0019722

calcium-mediated signaling

PMID:10611962[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030845

phospholipase C-inhibiting G-protein coupled receptor signaling pathway

PMID:16005297[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035556

intracellular signal transduction

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002219

P

Seeded From UniProt

complete

GO:0045471

response to ethanol

PMID:18675322[18]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0050896

response to stimulus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

GO:0050962

detection of light stimulus involved in sensory perception

PMID:16914683[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000370

positive regulation of clathrin-mediated endocytosis

PMID:25639794[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0003091

P

Seeded From UniProt

complete

colocalizes_with

GO:0005768

endosome

PMID:25639794[20]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Adamski, FM et al. (1998) Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies. J. Biol. Chem. 273 17713-9 PubMed GONUTS page
  2. 2.0 2.1 Morrison, DK et al. (2000) Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150 F57-62 PubMed GONUTS page
  3. Schaeffer, E et al. (1989) Isolation and characterization of two new drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. Cell 57 403-12 PubMed GONUTS page
  4. 4.0 4.1 Kumar, R & Shieh, BH (2001) The second PDZ domain of INAD is a type I domain involved in binding to eye protein kinase C. Mutational analysis and naturally occurring variants. J. Biol. Chem. 276 24971-7 PubMed GONUTS page
  5. Liu, W et al. (2011) The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye. Cell 145 1088-101 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Montell, C (1999) Visual transduction in Drosophila. Annu. Rev. Cell Dev. Biol. 15 231-68 PubMed GONUTS page
  7. Khanna, MR et al. (2010) Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. BMC Genomics 11 302 PubMed GONUTS page
  8. Stroschein-Stevenson, SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 4 e4 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Smith, DP et al. (1991) Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C. Science 254 1478-84 PubMed GONUTS page
  10. 10.0 10.1 Cohen, ED et al. (2002) DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis. Dev. Cell 2 437-48 PubMed GONUTS page
  11. Wang, N et al. (2008) Role of protein phosphatase 2A in regulating the visual signaling in Drosophila. J. Neurosci. 28 1444-51 PubMed GONUTS page
  12. Harteneck, C () Proteins modulating TRP channel function. Cell Calcium 33 303-10 PubMed GONUTS page
  13. Wang, T et al. (2005) Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J. Cell Biol. 171 685-94 PubMed GONUTS page
  14. Hardie, RC (2001) Phototransduction in Drosophila melanogaster. J. Exp. Biol. 204 3403-9 PubMed GONUTS page
  15. 15.0 15.1 Ranganathan, R et al. (1991) A Drosophila mutant defective in extracellular calcium-dependent photoreceptor deactivation and rapid desensitization. Nature 354 230-2 PubMed GONUTS page
  16. 16.0 16.1 Hardie, RC et al. (1993) Protein kinase C is required for light adaptation in Drosophila photoreceptors. Nature 363 634-7 PubMed GONUTS page
  17. Gu, Y et al. (2005) Mechanisms of light adaptation in Drosophila photoreceptors. Curr. Biol. 15 1228-34 PubMed GONUTS page
  18. Chen, J et al. (2008) A protein kinase C activity localized to neuropeptide Y-like neurons mediates ethanol intoxication in Drosophila melanogaster. Neuroscience 156 42-7 PubMed GONUTS page
  19. Popescu, DC et al. (2006) Scaffolding protein INAD regulates deactivation of vision by promoting phosphorylation of transient receptor potential by eye protein kinase C in Drosophila. J. Neurosci. 26 8570-7 PubMed GONUTS page
  20. 20.0 20.1 Lee, KA et al. (2015) Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes. Cell Host Microbe 17 191-204 PubMed GONUTS page